Sintesis Biodiesel Dari Minyak Sisa Pakai Dengan Variasi Waktu Reaksi Dan Ukuran Ba(oh)2 Sebagai Katalis

Ketersediaan bahan bakar fosil yang makin menipis jumlahnya menjadi pemicu bagi para peneliti untuk mengeksploarasi bahan bakar alternative terbaru-kan. Biodisel merupakan salah satu bahan bakar aternatif yang banyak dikembangkan, mulai dari teknologi, proses maupun bahan bakunya. Bahan baku yang sering digunakan berasal dari sawit, kelapa, zaitun, kanola maupun alpokat yang jika digunakan terus menerus akan menimbulkan masalah baru dibidang pangan. Minyak sisa pakai yang masih mengandung asam lemak menjadi salah satu bahan yang potensial sebagai bahan baku biodisel. Penggunaan katalis heterogen (Ba(OH)2.8H2O)pada variasi ukuran (25 dan 60 mesh) dan waktu reaksi (80–120 menit) sangat mempengaruhi biodisel yang dihasilkan. Biodisel dengan karakteristik terbaik didapatkan pada waktu reaksi selama 100 menit dengan ukuran katalis 60 mesh. Yield metil ester yang dihasilkan sebesar 86,8%

Moexipril and left ventricular hypertrophy

Angiotensin-converting enzyme (ACE) inhibitors today are the standard therapy of patients with myocardial infarction and heart failure due to their proven beneficial effects in left ventricular remodeling and left ventricular function. ACE inhibitors have also been demonstrated to lead to regression of left ventricular hypertrophy (LVH). It is believed that the mechanism of action of LVH regression with ACE inhibitors arises from more than simple blood pressure reduction. LVH is an important risk factor for cardiovascular disease morbidity and mortality independent of blood pressure. Moexipril hydrochloride is a long-acting, non-sulfhydryl ACE inhibitor that can be taken once daily for the treatment of hypertension. Moexipril has now also been demonstrated to have beneficial effects on LVH and can lead to LVH regression

Repurposing drugs to fast-track therapeutic agents for the treatment of cryptococcosis

Many infectious diseases disproportionately affect people in the developing world. Cryptococcal meningitis is one of the most common mycoses in HIV-AIDS patients, with the highest burden of disease in sub-Saharan Africa. Current best treatment regimens still result in unacceptably high mortality rates, and more effective antifungal agents are needed urgently. Drug development is hampered by the difficulty of developing effective antifungal agents that are not also toxic to human cells, and by a reluctance among pharmaceutical companies to invest in drugs that cannot guarantee a high financial return. Drug repurposing, where existing drugs are screened for alternative activities, is becoming an attractive approach in antimicrobial discovery programs, and various compound libraries are now commercially available. As these drugs have already undergone extensive optimisation and passed regulatory hurdles this can fast-track their progress to market for new uses. This study screened the Screen-Well Enzo library of 640 compounds for candidates that phenotypically inhibited the growth of Cryptococcus deuterogattii. The anthelminthic agent flubendazole, and L-type calcium channel blockers nifedipine, nisoldipine and felodipine, appeared particularly promising and were tested in additional strains and species. Flubendazole was very active against all pathogenic Cryptococcus species, with minimum inhibitory concentrations of 0.039-0.156 μg/mL, and was equally effective against isolates that were resistant to fluconazole. While nifedipine, nisoldipine and felodipine all inhibited Cryptococcus, nisoldipine was also effective against Candida, Saccharomyces and Aspergillus. This study validates repurposing as a rapid approach for finding new agents to treat neglected infectious diseases

PENGARUH E-SERVICE QUALITY TERHADAP E-TRUST DENGAN MODERASI EMBEDDED INSURANCE PADA LAYANAN PROTEKSI PRODUK DI SHOPEE

Berbelanja online melalui e-commerce telah menjadi bagian dari kebiasaan masyarakat Indonesia sehari-hari. Banyaknya kemudahan yang dirasakan menjadi alasan masyarakat gemar berbelanja online. Namun, banyaknya kemudahan yang dirasakan itu tidak menutup adanya risiko-risiko yang dapat menganggu pengalaman belanja dan menimbulkan kekecewaan. Kekecewaan konsumen terhadap e-service quality yang diberikan bisa berdampak buruk terhadap e-trust pada e-commerce tersebut. Oleh karena itu, diperlukan upaya penanggulangan risiko dengan memberikan jaminan berupa asuransi bagi konsumen e-commerce melalui teknologi embedded insurance. Penelitian ini dilakukan untuk mengetahui pengaruh e-service quality terhadap e-trust dengan moderasi embedded insurance pada layanan proteksi produk di Shopee. Pendekatan yang digunakan dalam penelitian ini adalah kuantitatif kausal dengan metode survey. Sampel dalam penelitian ini adalah pengguna aktif Shopee di Kota Bandung, Bekasi, Bogor, Depok, dan Tasikmalaya usia 17 – 39 tahun yang pernah menggunakan layanan proteksi produk di Shopee minimal satu kali. Data yang telah dikumpulkan kemudian diolah menggunakan pendekatan PLS-SEM menggunakan aplikasi SmartPLS 3.2.9. Hasil dari penelitian ini yaitu pertama e-service quality berpengaruh secara signifikan terhadap e-trust. Kedua terdapat pengaruh yang signifikan antara e-service quality terhadap e-trust dengan moderasi embedded insurance. Oleh karena itu, embedded insurance berhasil menjadi variabel moderasi dalam pengaruh e-service quality terhadap e-trust. Online shopping through e-commerce has become a part of the daily habits of Indonesian society. The ease and convenience are primary reasons people enjoy online shopping. However, these conveniences do not eliminate the risks that can disrupt the shopping experience and cause disappointment. Consumer disappointment with the provided e-service quality can negatively impact their trust in the e-commerce platform. Therefore, risk mitigation efforts are needed by offering guarantees in the form of insurance for e-commerce consumers with moderation of embedded insurance technology. This study aims to determine the effect of e-service quality on e-trust with the mediation of embedded insurance in the product protection service on Shopee. The research adopts a quantitative causal approach using a survey method. The sample includes active Shopee users in Bandung, Bekasi, Bogor, Depok, and Tasikmalaya, aged 17-39 years, who have used the product protection service on Shopee at least once. The collected data was processed using the PLS-SEM approach with the SmartPLS 3.2.9 application. The results are first, e-service quality significantly affects e-trust. Second, there is a significant effect of e-service quality on e-trust with moderation of embedded insurance. Therefore, embedded insurance successfully acts as a moderator variable in the effect of e-service quality on e-trust

Long-term efficacy of a combination of amlodipine and olmesartan medoxomil±hydrochlorothiazide in patients with hypertension stratified by age, race and diabetes status: a substudy of the COACH trial

A prespecified subgroup analysis of a 44-week open-label extension study is presented. The efficacy and safety of the combination of amlodipine (AML)+ olmesartan medoxomil (OM), with and without the addition of hydrochlorothiazide (HCTZ), were investigated in patients aged ⩾65 and <65 years, Blacks and non-Blacks and patients with and without type 2 diabetes. After an 8-week double-blind, placebo-controlled portion of the study, patients initiated therapy on AML 5+OM 40 mg per day, were uptitrated stepwise to AML 10+OM 40 mg per day, with the addition of HCTZ 12.5 mg, and 25 mg if blood pressure (BP) goal was not achieved (<140/90 or <130/80 mm Hg for patients with diabetes). Endpoints included the change from baseline in mean seated systolic BP, mean seated diastolic BP and achievement of BP goal. BP decreased from baseline for all treatments in each prespecified subgroup. By the end of the study, BP goal was achieved in 61.0% of patients aged ⩾65 years, 68.1% of patients aged <65 years, 63.3% of Blacks, 67.8% of non-Blacks, 26.9% of patients with diabetes and 72.9% of patients without diabetes. The combination of AML+OM±HCTZ was efficacious, safe and well tolerated by these subgroups

Expert consensus document: A 'diamond' approach to personalized treatment of angina.

In clinical guidelines, drugs for symptomatic angina are classified as being first choice (β-blockers, calcium-channel blockers, short-acting nitrates) or second choice (ivabradine, nicorandil, ranolazine, trimetazidine), with the recommendation to reserve second-choice medications for patients who have contraindications to first-choice agents, do not tolerate them, or remain symptomatic. No direct comparisons between first-choice and second-choice treatments have demonstrated the superiority of one group of drugs over the other. Meta-analyses show that all antianginal drugs have similar efficacy in reducing symptoms, but provide no evidence for improvement in survival. The newer, second-choice drugs have more evidence-based clinical data that are more contemporary than is available for traditional first-choice drugs. Considering some drugs, but not others, to be first choice is, therefore, difficult. Moreover, double or triple therapy is often needed to control angina. Patients with angina can have several comorbidities, and symptoms can result from various underlying pathophysiologies. Some agents, in addition to having antianginal effects, have properties that could be useful depending on the comorbidities present and the mechanisms of angina, but the guidelines do not provide recommendations on the optimal combinations of drugs. In this Consensus Statement, we propose an individualized approach to angina treatment, which takes into consideration the patient, their comorbidities, and the underlying mechanism of disease

SINTESIS BIODIESEL DARI MINYAK SISA PAKAI DENGAN VARIASI WAKTU REAKSI DAN UKURAN Ba(OH)2 SEBAGAI KATALIS

Ketersediaan bahan bakar fosil yang makin menipis jumlahnya menjadi pemicu bagi para peneliti untuk mengeksploarasi bahan bakar alternative terbaru-kan. Biodisel merupakan salah satu bahan bakar aternatif yang banyak dikembangkan, mulai dari teknologi, proses maupun bahan bakunya. Bahan baku yang sering digunakan berasal dari sawit, kelapa, zaitun, kanola maupun alpokat yang jika digunakan terus menerus akan menimbulkan masalah baru dibidang pangan. Minyak sisa pakai yang masih mengandung asam lemak menjadi salah satu bahan yang potensial sebagai bahan baku biodisel. Penggunaan katalis heterogen (Ba(OH)2.8H2O)pada variasi ukuran (25 dan 60 mesh) dan waktu reaksi (80–120 menit) sangat mempengaruhi biodisel yang dihasilkan. Biodisel dengan karakteristik terbaik didapatkan pada waktu reaksi selama 100 menit dengan ukuran katalis 60 mesh. Yield metil ester yang dihasilkan sebesar 86,8%