Wybieralność przedmiotów z perspektywy studentów

The article treats the problem of the place and function of the block of subjects in the humanities and management in the course of studies of a technical university. In Wrocław University of Technology, where the study was conducted, students elect particular courses from a block as electives. The authoress shows that the elective part of the curriculum may perform many functions, among others preparing students to make rational and responsible decisions. The necessary condition in this case, however, is an attractive programme offer, well prepared information about the courses available and efficient organisation of enrolment in these courses. In this context the authoress discusses the findings of studies of the motives that guide students in the selection of particular courses. In conclusion she finds an increasing share of substantive reasons, which are starting to outweigh haphazard choices.W artykule omówiony został problem miejsca i funkcji bloku przedmiotów humanistyczno-menedżerskich w programie studiów uczelni technicznej. I\la Politechnice Wrocławskiej, gdzie przeprowadzono badania, studenci wybierają określone kursy z omawianego bloku na zasadzie fakultatywności. Autorka wykazuje, iż fakultatywność części programu studiów może pełnić wiele funkcji, m.in. przygotowywać studentów do podejmowania racjonalnych i odpowiedzialnych decyzji. Warunkiem koniecznym jest wszakże w tym przypadku atrakcyjna oferta programowa, dobrze przygotowana informacja o oferowanych kursach oraz sprawna organizacja zapisów. W tym kontekście przedstawione zostały wyniki badań motywów, jakimi kierują się studenci przy wyborze określonych kursów. W konkluzji autorka stwierdza rosnący udział w tym procesie względów merytorycznych, które zaczynają wyraźnie dominować nad wyborami przypadkowymi

Methods for preliminary determination of pemetrexed in macromolecular drug-carrier systems

Pemetrexed (PMX) is an antifolate drug utilized in the treatment of non-small cell lung cancer. For studies of potential macromolecular carriers for PMX, fast and precise methods were developed to determine the bound and free drug contained in investigated conjugate preparations. The analysis of the total amount of PMX in conjugates was based on absorption spectrophotometry. The linearity was found in the range of 4.697–46.97 µmol L–1 PMX The limit of quantitation was 1.070 µmol L–1. The method for the analysis of unbound PMX was based on size-exclusion chromatography and detection at 225 nm. This method shows linear range of 2.230–223.0 µmol L–1. LOQ was 0.539 µmol L–1. The proposed methods can be used both for the characterization of the polysaccharide based conjugates of PMX and for the determination of conjugate drug release profiles

Polysaccharide BAP1 of Bifidobacterium adolescentis CCDM 368 is a biologically active molecule with immunomodulatory properties

Bifidobacteria are among the most common bacteria used for their probiotic properties and their impact on the maturation and function of the immune system has been well-described. Recently, scientific interest is shifting from live bacteria to defined bacteria-derived biologically active molecules. Their greatest advantage over probiotics is the defined structure and the effect independent of the viability status of the bacteria. Here, we aim to characterize Bifidobacterium adolescentis CCDM 368 surface antigens that include polysaccharides (PSs), lip-oteichoic acids (LTAs), and peptidoglycan (PG). Among them, Bad368.1 PS was observed to modulate OVA-induced cytokine production in cells isolated from OVA-sensitized mice by increasing the production of Th1-related IFN-gamma and inhibition of Th2-related IL-5 and IL-13 cytokines (in vitro). Moreover, Bad368.1 PS (BAP1) is efficiently engulfed and transferred between epithelial and dendritic cells. Therefore, we propose that the Bad368.1 PS (BAP1) can be used for the modulation of allergic diseases in humans. Structural studies revealed that Bad368.1 PS has an average molecular mass of approximately 9,99 x 106 Da and it consists of glucose, galactose, and rhamnose residues that are creating the following repeating unit: [-> 2)-beta-D-Glcp-(1 -> 3)-beta-L-Rhap-(1 -> 4)-beta-D-Glcp-(1 -> 3)-alpha-L-Rhap-(1 -> 4)-beta-D-Glcp-(1 -> 3)-alpha-D-Galp-(1 -> ]

phi YeO3-12 phage tail fiber Gp17 as a promising high specific tool for recognition of Yersinia enterocolitica pathogenic serotype O : 3

Yersiniosis is an infectious zoonotic disease caused by two enteropathogenic species of Gram-negative genus Yersinia: Yersinia enterocolitica and Yersinia pseudotuberculosis. Pigs and other wild and domestic animals are reservoirs for these bacteria. Infection is usually spread to humans by ingestion of contaminated food. Yersiniosis is considered a rare disease, but recent studies indicate that it is overlooked in the diagnostic process therefore the infections with this bacterium are not often identified. Reliable diagnosis of Yersiniosis by culturing is difficult due to the slow growth of the bacteria easily overgrown by other more rapidly growing microbes unless selec-tive growth media is used. Phage adhesins recognizing bacteria in a specific manner can be an excellent diagnostic tool, es-pecially in the diagnosis of pathogens difficult for culturing. In this study, it was shown that Gp17, the tail fiber protein (TFP) of phage phi YeO3-12, specifically recognizes only the pathogenic Yersinia enterocolitica serotype O:3 (YeO:3) bacteria. The ELISA test used in this work confirmed the specific interaction of this protein with YeO:3 and demonstrated a promising tool for developing the pathogen recognition method based on phage adhesins.Peer reviewe

Elective Courses from Students’ Perspective

W artykule omówiony został problem miejsca i funkcji bloku przedmiotów humanistyczno-menedżerskich w programie studiów uczelni technicznej. I\la Politechnice Wrocławskiej, gdzie przeprowadzono badania, studenci wybierają określone kursy z omawianego bloku na zasadzie fakultatywności. Autorka wykazuje, iż fakultatywność części programu studiów może pełnić wiele funkcji, m.in. przygotowywać studentów do podejmowania racjonalnych i odpowiedzialnych decyzji. Warunkiem koniecznym jest wszakże w tym przypadku atrakcyjna oferta programowa, dobrze przygotowana informacja o oferowanych kursach oraz sprawna organizacja zapisów. W tym kontekście przedstawione zostały wyniki badań motywów, jakimi kierują się studenci przy wyborze określonych kursów. W konkluzji autorka stwierdza rosnący udział w tym procesie względów merytorycznych, które zaczynają wyraźnie dominować nad wyborami przypadkowymi.The article treats the problem of the place and function of the block of subjects in the humanities and management in the course of studies of a technical university. In Wrocław University of Technology, where the study was conducted, students elect particular courses from a block as electives. The authoress shows that the elective part of the curriculum may perform many functions, among others preparing students to make rational and responsible decisions. The necessary condition in this case, however, is an attractive programme offer, well prepared information about the courses available and efficient organisation of enrolment in these courses. In this context the authoress discusses the findings of studies of the motives that guide students in the selection of particular courses. In conclusion she finds an increasing share of substantive reasons, which are starting to outweigh haphazard choices

Protection of technical equipment temporarily disabled from use against corrosion

W artykule zaprezentowane zostały wybrane aspekty przechowywania sprzętu echnicznego czasowo wyłączonego z użytkowania. Przedstawiona została charakterystyka podstawowych metod ochrony sprzętu technicznego przedoddziaływaniem korozji, naprzykładzie metod stosowanych w Siłach Zbrojnych Rzeczypospolitej Polskiej. Ponadto wskazane zostały najważniejsze determinanty odnoszące się do ochrony sprzętu technicznego przed oddziaływaniem korozji.In the article presented were selected aspects of the hardware store echnicznego temporarily disabled. Shows the characteristics of the basic methods of protecting technical equipment przedoddziaływaniem, naprzykładzie methods used in the armed forces of the Republic of Poland. In addition, indicated are the most important determinants of relating to the protection of technical equipment from the effects of corrosion