Monitoring of mental workload levels during an everyday life office-work scenario

Personal and ubiquitous healthcare applications offer new opportunities to prevent long-term health damage due to increased mental workload by continuously monitoring physiological signs related to prolonged high workload and providing just-in-time feedback. In order to achieve a quantification of mental load, different load levels that occur during a workday have to be discriminated. In this work, we present how mental workload levels in everyday life scenarios can be discriminated with data from a mobile ECG logger by incorporating individual calibration measures. We present an experiment design to induce three different levels of mental workload in calibration sessions and to monitor mental workload levels in everyday life scenarios of seven healthy male subjects. Besides the recording of ECG data, we collect subjective ratings of the perceived workload with the NASA Task Load Index (TLX), whereas objective measures are assessed by collecting salivary cortisol. According to the subjective ratings, we show that all participants perceived the induced load levels as intended from the experiment design. The heart rate variability (HRV) features under investigation can be classified into two distinct groups. Features in the first group, representing markers associated with parasympathetic nervous system activity, show a decrease in their values with increased workload. Features in the second group, representing markers associated with sympathetic nervous system activity or predominance, show an increase in their values with increased workload. We employ multiple regression analysis to model the relationship between relevant HRV features and the subjective ratings of NASA-TLX in order to predict the mental workload levels during office-work. The resulting predictions were correct for six out of the seven subjects. In addition, we compare the performance of three classification methods to identify the mental workload level during office-work. The best results were obtained with linear discriminant analysis (LDA) that yielded a correct classification for six out of the seven subjects. The k-nearest neighbor algorithm (k-NN) and the support vector machine (SVM) resulted in a correct classification of the mental workload level during office-work for five out of the seven subject

The change of stretched penile length and anthropometric data in Korean children aged 0-14 years: Comparative study of last 25 years

There has been a great improvement in height and weight of Korean children owing to economic development over the last 25 years. This study aimed to evaluate the penile length of Korean children today and to compare it with a previous Korean study reported in 1987. The cross-sectional study was conducted with 909 Korean boys aged 0-14 years who had been brought to outpatient clinics of five tertiary hospitals (Busan, Ulsan, and Changwon) between September 2013 and May 2015. The stretched penile length (SPL) was measured and the testicular size was measured using orchidometry (mL). Student's t-test or Mann-Whitney U test was used to compare the result of our study and the study reported in 1987. SPL of Korean children gradually increased from 4.1 ?? 0.8 cm at 0-1 year old to 9.6 ?? 3.0 cm at 13-14 years old, the most rapidly during the age of 13. While body weight and testicular size significantly increased from 1987 in most of age groups, there were no significant changes in SPL although there was in some age groups. Height decreased in the infants < 1 year old and increased in the children > 6 years old. With the great economic development over the last quarter century in Korea, height, body weight, and testicular size of children significantly increased but there was no significant change in SPL except penile growth pattern.ope

Turner syndrome and associated problems in turkish children: A multicenter study

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosi) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto’s thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%. Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan. © Journal of Clinical Research in Pediatric Endocrinology

Vitamin D, Insulin Resistance and Cytokine Levels in Obese Pubertal Children

Insulin resistance (IR) develops in obese children because of low vitamin levels and increased pro-inflammatory cytokine levels. This study aimed to analyze the relation between vitamin D, insulin resistance, tumor necrosis factor-alpha and interleukin 6 (IL-6) levels at admission and after weight loss. This study included 84 obese and 28 healthy pubertal children. Patient group was divided into four: IR positive and negative; weight loss (WL) positive and negative. Baseline and follow-up (6th month) values of serum 25-hydroxyvitamin D and other parameters were evaluated. The prevalence of serum vitamin D deficiency and insufficiency were 3.6% and 21.4% in the control group, 15.2% and 10.9% and 7.9% and 15.8% in the obese insulin positive and negative group; respectively. There was no relationship between vitamin D and IRand IL-6 levels, whereas cytokine levels were lower in obese children. As WL increased, vitamin D level and IR improved. No significant difference was found between vitamin D levels of obese and control subjects. In obese children with weight loss, an insignificant increase was observed in vitamin D, cytokines, quantitative insulin sensitivity check index values and an insignificant decrease was noted in homeostatic model assessment for IR value. Further longitudinal studies with larger patient series with greater WL are warranted

Plasma leptin levels in infants of diabetic mothers in fasting and satiety states

Infants born to diabetic mothers have elevated cord blood leptin levels. The aim of this study was to investigate whether the situation persists at the 2nd postnatal day, taking the fasting and satiety states into account and the influence of fetal exposure to hyperinsulinemia, which are proven important contributing factors to plasma leptin levels. Twenty infants born to mothers with gestational diabetes (Group I) and 20 controls (Group II) were included in the study. Groups were similar for sex and anthropometric measurements. Group I had higher leptin concentrations compared to Group II in fasting and satiety states (p < 0.01). Fasting state leptin levels were significantly lower than seen in satiety in both groups (p < 0.01). There was a positive and significant correlation between leptin concentrations and body mass index of infants. Leptin concentrations were positively correlated with plasma insulin levels in Group I. These findings suggest that plasma leptin levels are high in both fasting and satiety states on the 2nd postnatal day in infants born to mothers with gestational diabetes. The possible mechanism underlying this condition is fetal exposure to hyperinsulinemia due to hyperglycemia. The uniqueness of this report are that fasting and satiety states were taken into account and that the data was collected from the samples taken on the 2nd postnatal day, thus reflecting the exact milieu of the infant excluding the effects of the mother and the placenta

Volume CXIV, Number 4, November 7, 1996

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population.Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014.Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosis) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto's thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%.Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespa

Mü'min Bin Mukbil Sinobi/ Miftahu'n-Nur Haza'inü's-Sürur

Bu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır. Yayınlanma izni olmayan tezlerin basılı kopyalarına Üniversite kütüphaneniz aracılığıyla (TÜBESS üzerinden) erişebilirsiniz.Sosyal Bilimler Enstitüsü, Türk Dili ve Edebiyatı Ana Bilim Dalı, Türk Dili Bilim DalıÖZET Hekim Sinoplu Mümin bin Mukbil'in "Miftâhu'n-Nûr Hazâinii's-Sürûr" adlı eseri t Osmanlı Devletinde 15. yüzyılda yazılmış önemli tıp kitaplarından biridir. Asıl konusu göz hastalıkları ve tedavisi olan eserde anatomi, sağlık bilgisi ve baş ağrılarından da bahsedilir. Eser, hem Türk tıp tarihi açısından hem de Türkçenin o dönem tıp ilmi karşısındaki durumunu göstermesi bakımından önemli bir kaynaktır. Ayrıca bu alanda yapılan dil çalışmalarının az olması da bizi tıpla ilgili bir metin üzerinde çalışmaya yöneltmiştir. Çalışmamızda, sözü edilen eserin Nuruosmaniye Kütüphanesi nüshası esas alınmıştır. Öncelikle yazı çevrimi yapılan eser, Ali Emiri Kütüphanesi nüshası ile karşılaştırılarak her iki nüsha arasındaki farklar dipnotta verilmiştir. Eserin dil bilgisi incelemesi yapılarak kitapta geçen bütün kelimeler, kelimelerin anlamlan ve geçtiği yerler belirtilmiştir. Sonuç olarak eserin Eski Anadolu Türkçesi özelliklerini taşıdığını, tıpla ilgili bir metin olmasından ötürü tıbbî terimlerin ve ilaç adlarının -özellikle Arapça ve Yunanca- çok sık kullanıldığını söyleyebiliriz.II SUMMARY "Miftâhu'n-Nür Hazâinü's-Sürûr" by Hekim Sinoplu Mümin bin Mukbil was one of the important medical books in the Ottoman Empire of 1 5th century. Though its main focus was on the ilnesses related to the eyes, the work mentions about the anatomy, headaches and general health knowledge. The work is an important source both for the history of Turkish medicine and for the Turkish language in which it was used in such a medical context. Moreover, the reality that there are very few language studies in this field has directed us to study on a medical text. In this study, it is bene fited from the version of Miftâhu'n-Nûr Hazâinü's-Sürûr kept in Nuruosmaniye Library. Firstly, the work has been translated into the new alphabet. Then, this has been compared with the another version kept in Ali Emiri Library, and the discrepancies between two versions have been explained at the footnotes. The whole grammar has been examined, and all the words used in the work have been stated together with their meanings and where they were used. As a result, it can be said that the work bears the characteristics of ancient Anatolian Turkish; since it is a medical text, medical terms and drug titles, especially in Arabic and Greek, have been often used throughout the work