The PHENIX Experiment at RHIC

The physics emphases of the PHENIX collaboration and the design and current status of the PHENIX detector are discussed. The plan of the collaboration for making the most effective use of the available luminosity in the first years of RHIC operation is also presented.Comment: 5 pages, 1 figure. Further details of the PHENIX physics program available at http://www.rhic.bnl.gov/phenix

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Supernova Remnants Interacting with Molecular Clouds: X-Ray and Gamma-Ray Signatures

The giant molecular clouds (MCs) found in the Milky Way and similar galaxies play a crucial role in the evolution of these systems. The supernova explosions that mark the death of massive stars in these regions often lead to interactions between the supernova remnants (SNRs) and the clouds. These interactions have a profound effect on our understanding of SNRs. Shocks in SNRs should be capable of accelerating particles to cosmic ray (CR) energies with efficiencies high enough to power Galactic CRs. X-ray and γ-ray studies have established the presence of relativistic electrons and protons in some SNRs and provided strong evidence for diffusive shock acceleration as the primary acceleration mechanism, including strongly amplified magnetic fields, temperature and ionization effects on the shock-heated plasmas, and modifications to the dynamical evolution of some systems. Because protons dominate the overall energetics of the CRs, it is crucial to understand this hadronic component even though electrons are much more efficient radiators and it can be difficult to identify the hadronic component. However, near MCs the densities are sufficiently high to allow the γ-ray emission to be dominated by protons. Thus, these interaction sites provide some of our best opportunities to constrain the overall energetics of these particle accelerators. Here we summarize some key properties of interactions between SNRs and MCs, with an emphasis on recent X-ray and γ-ray studies that are providing important constraints on our understanding of cosmic rays in our Galaxy