Comparative analysis of cannabis legalization in South Africa and Zimbabwe: trajectories, commonalities, and divergences

The legalization of cannabis, a subject of significant socio-economic and legal interest, has prompted diverse approaches across different nations. This article presents a comprehensive examination of the legalization processes in South Africa and Zimbabwe, two African countries with distinct yet interlinked histories and socio-political contexts. Using qualitative interview data and documentary analysis, it provides an in-depth comparative analysis examining the unique pathways each country has followed in the legalization of cannabis, highlighting the commonalities, differences, and possible impacts on livelihoods and each economy. In South Africa, the journey towards legalization gained momentum following a landmark Constitutional Court ruling in 2018, which decriminalized private cannabis use and cultivation. This decision, rooted in rights-based arguments around privacy, ignited a broader discussion about the socio-economic benefits of legalization, particularly in the context of historical injustices and economic disparities. South Africa’s approach has been characterized by a gradual, cautious transition, balancing public health concerns with potential economic opportunities in the cannabis industry. In contrast, Zimbabwe’s decision in 2018 to legalize the cultivation of cannabis for medicinal and industrial purposes marked a significant shift, primarily aimed at boosting economic growth and diversifying agricultural exports. This move, while economically motivated, also reflects Zimbabwe’s efforts to leverage cannabis as a strategic cash crop to boost the struggling economy worsened by western-imposed economic restrictions, maladministration and corruption, among other factors. The comparative analysis reveals both similarities and divergences in the legal frameworks, public discourse, and implementation strategies of cannabis legalization in these nations

Business as usual? Cannabis legalisation and agrarian change in Zimbabwe

This article examines the emerging legal cannabis sector in Zimbabwe since 2018, which focuses on medicinal and industrial cannabis with unlicenced uses remaining criminalised, as well as its implications for agrarian change. It shows that the formal sector is set up in a way that prioritises those with substantial resources – marginalising small-scale farmers and illicit cultivators. While this presents the risk of corporate capture, various factors combine to undermine agribusiness' production. However, prohibition of recreational cannabis and the formal sector’s focus on export markets combine to preserve illicit cannabis markets and allow continuation of illicit livelihoods

Business as usual? Cannabis legalisation and agrarian change in Zimbabwe

This article examines the emerging legal cannabis sector in Zimbabwe since 2018, which focuses on medicinal and industrial cannabis with unlicenced uses remaining criminalised, as well as its implications for agrarian change. It shows that the formal sector is set up in a way that prioritises those with substantial resources – marginalising small-scale farmers and illicit cultivators. While this presents the risk of corporate capture, various factors combine to undermine agribusiness' production. However, prohibition of recreational cannabis and the formal sector’s focus on export markets combine to preserve illicit cannabis markets and allow continuation of illicit livelihoods

Tendências mercadológicas

O mercado é muito dinâmico e novas tendências surgem constantemente. Um dos fatores que contribui para esse dinamismo é o aumento do nível de exigência dos consumidores que, devido ao acesso facilitado às informações, tornam-se mais conscientes de seus direitos e deveres e, portanto, muito mais exigentes. As empresas que pretendem atuar neste mercado competitivo com destaque necessitam realizar pesquisas buscando prever essas tendências, a fim de oferecer produtos que atendam as necessidades e os desejos dos seus consumidores. Este artigo tem por objetivo apresentar algumas tendências de mercado identificadas a partir de pesquisas realizadas em revistas, jornais e outros periódicos e por meio de coleta de dados oriundos de entrevistas com pessoas de notório saber em diferentes áreas de atuação

BHPR research: qualitative1. Complex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis

Background: Foot surgery is common in patients with RA but research into surgical outcomes is limited and conceptually flawed as current outcome measures lack face validity: to date no one has asked patients what is important to them. This study aimed to determine which factors are important to patients when evaluating the success of foot surgery in RA Methods: Semi structured interviews of RA patients who had undergone foot surgery were conducted and transcribed verbatim. Thematic analysis of interviews was conducted to explore issues that were important to patients. Results: 11 RA patients (9 ♂, mean age 59, dis dur = 22yrs, mean of 3 yrs post op) with mixed experiences of foot surgery were interviewed. Patients interpreted outcome in respect to a multitude of factors, frequently positive change in one aspect contrasted with negative opinions about another. Overall, four major themes emerged. Function: Functional ability & participation in valued activities were very important to patients. Walking ability was a key concern but patients interpreted levels of activity in light of other aspects of their disease, reflecting on change in functional ability more than overall level. Positive feelings of improved mobility were often moderated by negative self perception ("I mean, I still walk like a waddling duck”). Appearance: Appearance was important to almost all patients but perhaps the most complex theme of all. Physical appearance, foot shape, and footwear were closely interlinked, yet patients saw these as distinct separate concepts. Patients need to legitimize these feelings was clear and they frequently entered into a defensive repertoire ("it's not cosmetic surgery; it's something that's more important than that, you know?”). Clinician opinion: Surgeons' post operative evaluation of the procedure was very influential. The impact of this appraisal continued to affect patients' lasting impression irrespective of how the outcome compared to their initial goals ("when he'd done it ... he said that hasn't worked as good as he'd wanted to ... but the pain has gone”). Pain: Whilst pain was important to almost all patients, it appeared to be less important than the other themes. Pain was predominately raised when it influenced other themes, such as function; many still felt the need to legitimize their foot pain in order for health professionals to take it seriously ("in the end I went to my GP because it had happened a few times and I went to an orthopaedic surgeon who was quite dismissive of it, it was like what are you complaining about”). Conclusions: Patients interpret the outcome of foot surgery using a multitude of interrelated factors, particularly functional ability, appearance and surgeons' appraisal of the procedure. While pain was often noted, this appeared less important than other factors in the overall outcome of the surgery. Future research into foot surgery should incorporate the complexity of how patients determine their outcome Disclosure statement: All authors have declared no conflicts of interes

A partial prehistory of the Southwest Silk Road: Archaeometallurgical networks along the sub-Himalayan corridor

Historical phenomena often have prehistoric precedents, with this paper we investigate the potential for archaeometallurgical analyses and networked data processing to elucidate the progenitors of the Southwest Silk Road in Mainland Southeast Asia and southern China. We present original microstructural, elemental and lead isotope data for 40 archaeological copperbase metal samples, mostly from the UNESCO-listed site of Halin, and lead isotope data for 25 geological copper-mineral samples, also from Myanmar. We combined these data with existing datasets (N=98 total) and compared them to the 1000+ sample late prehistoric archaeometallurgical database available from Cambodia, Laos, Thailand, Vietnam and Yunnan. Lead isotope data, contextualised for alloy, find location and date, were interpreted manually for intra-site, inter-site and inter-regional consistency, which hint at significant multi-scalar connectivity from the late 2nd millennium BC. To test this interpretation statistically, the archaeological lead isotope data were then processed using regionally-adapted productionderived consistency parameters. Complex networks analysis using the Leiden community detection algorithm established groups of artefacts sharing lead isotopic consistency. Introducing the geographic component allowed for the identification of communities of sites with consistent assemblages. The four major communities were consistent with the manually interpreted exchange networks and suggest southern sections of the Southwest Silk Road were active in the late 2nd millennium BC

A Near-infrared Variability Survey of Young Planetary-mass Objects

We present a photometric variability survey of young planetary-mass objects using the New Technology Telescope in the Js and Ks bands. Surface gravity plays an important role in the atmospheric structure of brown dwarfs, as young low gravity L dwarfs have a higher variability rate than field L dwarfs. In this study, we extend variability studies to young T-type planetary-mass objects and investigate the effects of surface gravity on the variability of L and T dwarfs across a large sample. We conduct continuous monitoring for 18 objects with spectral types from L5 to T8 and detect four new variables and two variable candidates. Combining with previous variability surveys of field and young L and T objects, we find that young objects tend to be more variable than field objects within peak-to-peak variability amplitude ranges of 0.5-10 per cent and period ranges of 1.5-20 hr. For the first time, we constrain the variability rate of young T dwarfs to be 56 per cent compared to 25 per cent for field T dwarfs. Both field and young samples have higher variability rates at the L/T transition than outside the L/T transition. The differences in the variability rates between field and young samples are about 1 sigma and therefore larger sample sizes are needed to confirm and refine the results. Besides the L/T transition, young L dwarfs with strong variability tend to assemble in a narrow spectral type range of L6-L7.5. This work supports the critical role of surface gravity on the atmospheric structure from L to T spectral types.Comment: Accepted for publication in MNRAS, 21 pages of main text including 6 tables and 17 figure

Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination.

Immunogenicity is considered one important criterion for progression of candidate vaccines to further clinical evaluation. We tested this assumption in an infection and vaccination model for malaria pre-erythrocytic stages. We engineered Plasmodium berghei parasites that harbour a well-characterised epitope for stimulation of CD8+ T cells, either as an antigen in the sporozoite surface-expressed circumsporozoite protein or the parasitophorous vacuole membrane associated protein upregulated in sporozoites 4 (UIS4) expressed in exo-erythrocytic forms (EEFs). We show that the antigen origin results in profound differences in immunogenicity with a sporozoite antigen eliciting robust, superior antigen-specific CD8+ T-cell responses, whilst an EEF antigen evokes poor responses. Despite their contrasting immunogenic properties, both sporozoite and EEF antigens gain access to antigen presentation pathways in hepatocytes, as recognition and targeting by vaccine-induced effector CD8+ T cells results in high levels of protection when targeting either antigen. Our study is the first demonstration that poorly immunogenic EEF antigens do not preclude their susceptibility to antigen-specific CD8+ T-cell killing, which has wide-ranging implications on antigen prioritisation for next-generation pre-erythrocytic malaria vaccines

Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.

To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTS Calcr abrogated the long-term suppression of food intake, but not aversive responses, by CALCR agonists. Similarly, activating CalcrNTS neurons decreased food intake and body weight but (unlike neighboring CckNTS cells) failed to promote aversion, revealing that CalcrNTS neurons mediate a non-aversive suppression of food intake. While both CalcrNTS and CckNTS neurons decreased feeding via projections to the PBN, CckNTS cells activated aversive CGRPPBN cells while CalcrNTS cells activated distinct non-CGRP PBN cells. Hence, CalcrNTS cells suppress feeding via non-aversive, non-CGRP PBN targets. Additionally, silencing CalcrNTS cells blunted food intake suppression by gut peptides and nutrients, increasing food intake and promoting obesity. Hence, CalcrNTS neurons define a hindbrain system that participates in physiological energy balance and suppresses food intake without activating aversive systems

Pathogenic variants in the paired-related homeobox 1 gene (PRRX1) cause craniosynostosis with incomplete penetrance

Purpose Studies previously implicated PRRX1 in craniofacial development, including demonstration of murine Prrx1 expression in the pre-osteogenic cells of the cranial sutures. We investigated the role of heterozygous missense and loss-of-function variants in PRRX1 associated with craniosynostosis. Methods Trio-based genome, exome or targeted sequencing were used to screen PRRX1 in patients with craniosynostosis; immunofluorescence analyses were used to assess nuclear localization of wild-type and mutant proteins. Results Genome sequencing identified 2 of 9 sporadically affected individuals with syndromic/multisuture craniosynostosis who were heterozygous for rare/undescribed variants in PRRX1. Exome or targeted sequencing of PRRX1 revealed a further 9/1449 patients with craniosynostosis harboring deletions or rare heterozygous variants within the homeodomain. By collaboration, seven additional individuals (four families) were identified with putatively pathogenic PRRX1 variants. Immunofluorescence analyses showed that missense variants within the PRRX1 homeodomain cause abnormal nuclear localization. Of patients with variants considered likely pathogenic, bicoronal or other multi-suture synostosis was present in 11/17 (65% of the cases). Pathogenic variants were inherited from unaffected relatives in many instances, yielding a 12.5% penetrance estimate for craniosynostosis. Conclusion This work supports a key role for PRRX1 in cranial suture development and shows that haploinsufficiency of PRRX1 is a relatively frequent cause of craniosynostosis