The UK vs Sweden : Is the NHS really so bad?

Sheng-Chia Chung and colleagues report in The Lancet (23 January 2014) an international comparison of cardiovascular patient mortality between the UK and Sweden. They suggest that “more than 10000 deaths at 30 days would have been prevented or delayed had UK patients experienced the care of their Swedish counterparts.” Further, they estimate that 1741 deaths would have been prevented in the UK had the Swedish pattern of primary percutaneous coronary intervention (PCI) and beta-blocker use been replicated in the NHS from 2004 to 2010. However, their study does not provide convincing evidence that faster uptake of primary PCI or beta-blockers on discharge would have had an effect on cardiovascular patient mortality in the UK

Malaria vector control at crossroads: public health entomology and the drive to elimination

Vector control has been at the core of successful malaria control. However, a dearth of field-oriented vector biologists threatens to undermine global reductions in malaria burden. Skilled cadres are needed to manage insecticide resistance, to maintain coverage with current interventions, to develop new paradigms for tackling ‘residual' transmission, and to target interventions as transmission becomes increasingly heterogeneous. Recognising this human resource crisis, in September 2013, WHO Global Malaria Programme issued guidance for capacity building in entomology and vector control, including recommendations for countries and implementing partners. Ministries were urged to develop long-range strategic plans for building human resources for public health entomology and vector control (including skills in epidemiology, geographic information systems, operational research and programme management) and to set in place the requisite professional posts and career opportunities. Capacity building and national ownership in all partner projects and a clear exit strategy to sustain human and technical resources after project completion were emphasised. Implementing partners were urged to support global and regional efforts to enhance public health entomology capacity. While the challenges inherent in such capacity building are great, so too are the opportunities to establish the next generation of public health entomologists that will enable programmes to continue on the path to malaria eliminatio

OX133, a monoclonal antibody recognizing protein-bound N-ethylmaleimide for the identification of reduced disulfide bonds in proteins

In vivo, enzymatic reduction of some protein disulfide bonds, allosteric disulfide bonds, provides an important level of structural and functional regulation. The free cysteine residues generated can be labeled by maleimide reagents, including biotin derivatives, allowing the reduced protein to be detected or purified. During the screening of monoclonal antibodies for those specific for the reduced forms of proteins, we isolated OX133, a unique antibody that recognizes polypeptide resident, N-ethylmaleimide (NEM)-modified cysteine residues in a sequence-independent manner. OX133 offers an alternative to biotin-maleimide reagents for labeling reduced/alkylated antigens and capturing reduced/alkylated proteins with the advantage that NEM-modified proteins are more easily detected in mass spectrometry, and may be more easily recovered than is the case following capture with biotin based reagents

Investigation of Physicochemical and Mechanical Property of UTAN Granites for Building Applications

The granite formation for production of dimension stone blocks at Utan was investigated in three different locations A, B and C in a view to examine the physical properties of Utan granite using saturation and Buoyancy technique; evaluate some of its mechanical properties; determine its rate of emission of radioactive elements with Geiger Muller Counter; examine its polish-ability; and carry out chemical analysis of the granite samples with the aid of energy dispersive x-ray florescence (ED-XRF). The average porosity obtained is 0.53, 1.08; and 0.86 while the respective average density of 2.58, 2.62 and 2.60 g/cm3 were obtained for A, B and C. The compressive strength of 207.5, 204.6 and 203.4 MPa; and tensile strength of 13.86, 13.68 and 13.60 MPa were obtained for A, B and C respectively. Rockwell hardness values obtained are 89.0, 89.9 and 86.6 while the morh’s hardness values are 6.90, 6.96 and 7.03 respectively for sample A; B and C. The impact values obtained are 0.089, 0.092 and 0.094 for A, B and C respectively. The radioactive rates of samples A, B and C are 6.42, 8.86 and 8.16 Mrem respectively. Sample B is observed to be more radioactive. Both samples are polish able. Conclusively, the three tested granite rocks have suitable physical and mechanical properties that meant the requirement for building purposes; from the polish-ability test, it shows that the three (3) granite outcrops are suitable for the production of granite tiles; countertops; slabs. The chemical analysis revealed that the granite is dominated by quartz (SiO2) which contributes greatly to the hardness of the rock. Also from the radioactive test, the granite samples proved conclusively that the rate of radiation found occasionally in a slab of granite is not harmful to humans when exposed to it. Hence, granite the formation of Utan will be a good building stone material

Compact radio sources:Triggering and feedback

CSS/GPS objects represent a key stage in the evolution of powerful radio AGN in which the jets are expanding through the denser, kpc-scale ISM in the host galaxies. Therefore, it is important both to understand how such radio AGN are triggered as galaxies evolve and to directly quantify the impact of the outflows induced by the jet-cloud interactions. Here, we show that CSS/GPS sources are likely to be triggered in galaxy mergers, just like powerful radio AGN in general. However, they are both more gas-rich and have higher star formation rates on average than their more extended counterparts. Also, whereas observations frequently show evidence for strong jet-cloud interactions in CSS/GPS in the form of warm outflows, in most cases these warm outflows are unlikely to be energetic enough to affect the star formation histories of the entire host galaxies outside the central kpc. Rather, much of the mass, energy, and momentum of the outflows appear to be tied up in neutral and molecular outflows, which may have a more important impact on the host galaxies. Finally, we consider whether CSS/GPS sources are impostors in flux-limited samples due to the effect of the strong jet-cloud interactions on their radio luminosities

Modelling of combined ICRF and NBI heating in JET hybrid plasmas

During the 2015-2016 JET campaigns many efforts have been devoted to the exploration of high performance plasma scenarios envisaged for ITER operation. In this paper we model the combined ICRF+NBI heating in selected key hybrid discharges using PION. The antenna frequency was tuned to match the cyclotron frequency of minority hydrogen (H) at the center of the tokamak coinciding with the second harmonic cyclotron resonance of deuterium. The modelling takes into account the synergy between ICRF and NBI heating through the second harmonic cyclotron resonance of deuterium beam ions which allows us to assess its impact on the neutron rate RNT. We evaluate the influence of H concentration which was varied in different discharges in order to test their role in the heating performance. According to our modelling, the ICRF enhancement of RNT increases by decreasing the H concentration which increases the ICRF power absorbed by deuterons. We find that in the recent hybrid discharges this ICRF enhancement was in the range of 10-25%. Finally, we extrapolate the results to D-T and find that the best performing hybrid discharges correspond to an equivalent fusion power of ∼7.0 MW in D-T.This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014-2018 under grant agreement No 633053. The views and opinions expressed herein do not necessarily reflect those of the European Commission. Dani Gallart would like to thank “La Caixa” for support of his PhD studies.Peer ReviewedPostprint (published version

Police et ordre public en France et en Angleterre (1750-1850). Les perspectives de l’historiographie contemporaine

Les études réunies dans le présent numéro ont été présentées le 4 ?avril 2014 lors de la conférence que nous avions organisée à l’Institut d’Études avancées de Paris sur le thème « Police et ordre public en France et en Angleterre (1750-1850). Perspectives de l’historiographie contemporaine ». La rencontre se situait dans le cadre du renouveau majeur des recherches menées dans le domaine de l’histoire des polices, de part et d’autre de la Manche. Dans un contexte scientifique particulièrement..