Evaluation of Age UK Eatwell and Livewell Programme

The Eatwell and Livewell Programme was set up in 2014 to provide support in the malnutrition pathway for older people within two Yorkshire areas. This report presents the findings from an evaluation of the programme conducted by the Centre for Health Promotion Research, Leeds Beckett University. It presents evidence about the project’s background, its progress in relation to target outputs, the outcomes for service users, and learning from both delivery sites

Evaluation of Joint Pilot: Health and Well-Being Support Worker - Locala and Connect Housing Final Evaluation Report

The joint housing and health pilot project was set up in September 2015 as a prototype approach aiming to improve the health and well-being of people with complex health needs within the Batley and Spen Valley localities. The project was co-commissioned by Locala, a provider of NHS community services and Connect Housing, a charitable housing association based in the voluntary sector. This report presents the findings from an evaluation of the joint pilot project conducted by the Centre for Health Promotion Research, Leeds Beckett University. It presents evidence about the project’s background, the outcomes for service users, the Health and Support Worker role, multi-agency working, reductions in health service usage costs, and maps the evaluation evidence against Care Closer to Home Key Performance Indicators as well as overall learning from the project

A continuous sampling scheme for edge illumination x-ray phase contrast imaging

We discuss an alternative acquisition scheme for edge illumination (EI) x-ray phase contrast imaging (XPCi) based on a continuous scan of the object, and compare its performance to that of a previously used scheme, which involved scanning the object in discrete steps rather than continuously. By simulating signals for both continuous and discrete methods under realistic experimental conditions, the e ect of the spatial sampling rate is analysed with respect to metrics such as image contrast and accuracy of the retrieved phase shift. Experimental results con rm the theoretical predictions. Despite being limited to a speci c example, the results indicate that continuous schemes present advantageous features compared to discrete ones. Not only can they be used to speed up the acquisition, but they also prove superior in terms of accurate phase retrieval. The theory and experimental results provided in this study will guide the design of future EI experiments through the implementation of optimised acquisition schemes and sampling rates

Lifetime Difference and Endpoint effect in the Inclusive Bottom Hadron Decays

The lifetime differences of bottom hadrons are known to be properly explained within the framework of heavy quark effective field theory(HQEFT) of QCD via the inverse expansion of the dressed heavy quark mass. In general, the spectrum around the endpoint region is not well behaved due to the invalidity of $1/m_Q$ expansion near the endpoint. The curve fitting method is adopted to treat the endpoint behavior. It turns out that the endpoint effects are truly small and the explanation on the lifetime differences in the HQEFT of QCD is then well justified. The inclusion of the endpoint effects makes the prediction on the lifetime differences and the extraction on the CKM matrix element $|V_{cb}|$ more reliable.Comment: 11 pages, Revtex, 10 figures, 6 tables, published versio

Homeshare Scheme

Homeshare is a scheme in which older people – ‘Homeowners’ - provide an affordable home to young professionals or possibly students – ‘Homesharers’ - in exchange for help or support with everyday tasks (e.g. shopping and cleaning), and companionship. This pairing is intended to be mutually beneficial, whereby older people are provided with help and support to live independently and young people are offered a much needed home. There are similar schemes in London, but nothing like this is currently in place in Leeds. This report presents findings from a research project conducted in Leeds to investigate the demand for this service and the feasibility of this type of scheme. The research was funded by Leeds Metropolitan University and Leeds City Council

Exploring the role of fallopian ciliated cells in the pathogenesis of high-grade serous ovarian cancer

High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in women and the first among gynecological malignancies. Despite an initial response to standard chemotherapy, most HGSOC patients relapse. To improve treatment options, we must continue investigating tumor biology. Tumor characteristics (e.g., risk factors and epidemiology) are valuable clues to accomplish this task. The two most frequent risk factors for HGSOC are the lifetime number of ovulations, which is associated with increased oxidative stress in the pelvic area caused by ovulation fluid, and a positive family history due to genetic factors. In the attempt to identify novel genetic factors (i.e., genes) associated with HGSOC, we observed that several genes in linkage with HGSOC are expressed in the ciliated cells of the fallopian tube. This finding made us hypothesize that ciliated cells, despite not being the cell of origin for HGSOC, may take part in HGSOC tumor initiation. Specifically, malfunction of the ciliary beat impairs the laminar fluid flow above the fallopian tube epithelia, thus likely reducing the clearance of oxidative stress caused by follicular fluid. Herein, we review the up-to-date findings dealing with HGSOC predisposition with the hypothesis that fallopian ciliated cells take part in HGSOC onset. Finally, we review the up-to-date literature concerning genes that are located in genomic loci associated with epithelial ovarian cancer (EOC) predisposition that are expressed by the fallopian ciliated cells

Strategies for fast and low-dose laboratory-based phase contrast tomography for microstructural scaffold analysis in tissue engineering

The application of x-ray phase contrast computed tomography (PCT) to the field of tissue engineering is dis- cussed. Specific focus is on the edge illumination PCT method, which can be adapted to weakly coherent x-ray sources, permitting PCT imaging in standard (non-synchrotron) laboratory environments. The method was applied to a prominent research topic in tissue engineering, namely the development of effective and reliable decellularization protocols to derive scaffolds from native tissue. Results show that edge illumination PCT provides sufficient image quality to evaluate the microstructural integrity of scaffolds and, thus, to assess the performance of the used decellularization technique. In order to highlight that edge illumination PCT can ultimately comply with demands on a high specimen throughput and low doses of radiation, recently developed strategies for scan time and dose reduction are discussed

Photon polarization in radiative B decays

We study decay distributions in B -> K pi pi gamma, combining contributions from several overlapping resonances in a K pi pi mass range near 1400 MeV, (1^+) K_1(1400), (2^+) K^*_2(1430) and (1^-) K^*(1410). A method is proposed for using these distributions to determine a photon polarization parameter in the effective radiative weak Hamiltonian. This parameter is measured through an up-down asymmetry of the photon direction relative to the K pi pi decay plane. We calculate a dominant up-down asymmetry of 0.33 +- 0.05 from the K1(1400) resonance, which can be measured with about 10^8 B B-bar pairs, thus providing a new test for the Standard Model and a probe for some of its extensions.Comment: 22 pages, 3 figures, version to appear in Phys. Rev.