Hypothesis: ‘Vasocrine’ signalling from perivascular fat - a mechanism linking insulin resistance and vascular disease

Adipose tissue expresses cytokines which inhibit insulin signalling pathways in liver and muscle. Obesity also results in impairment of endothelium-dependent vasodilatation to insulin. We propose a vasoregulatory role for local deposits of fat around the origin of arterioles supplying skeletal muscle. Isolated first order arterioles from rat cremaster muscle are under dual regulation by insulin, which activates both endothelin-1 mediated vasoconstriction and nitric oxide mediated vasodilatation. In obese rat arterioles, insulin-stimulated nitric oxide synthesis is impaired, resulting in unopposed vasoconstriction. We propose this to be the consequence of production of the adipocytokine tumour necrosis factor-α from the cuff of fat seen surrounding the origin of the arteriole in obese rats – a depot to which we ascribe a specialist vasoregulatory role. We suggest that this cytokine accesses the nutritive vascular tree to inhibit insulin-mediated capillary recruitment – a mechanism we term ‘vasocrine’ signalling. We also suggest a homology between this vasoactive periarteriolar fat and both periarterial and visceral fat, which may explain relationships between visceral fat, insulin resistance and vascular disease

Factor Price Equalization in Heckscher-Ohlin Model

This paper investigates the likelihood of factor-price equalization under the simple assumptions of Heckscher-Ohlin Theory. Factor-price equalization is also directly related to whether countries specialize or not in the global market. A full-equilibrium in the world requires not only the equilibrium in the production side of the economy, but also the supply-demand equality in the world. However, once we obtain an equilibrium in the production side of the economy, it is always possible to define demand in a way to get supply-demand equality at any production side equilibrium amounts. Therefore, it is not possible to talk about factor-price equalization without specifying demand in the economy. Using L-P diagrams, the paper demonstrates how both factor-price equalization and non-equalization cases are possible when we look at only the production side of the economy. It is also demonstrated that the equilibrium possibilities will be much larger for factor-price equalization case if the number of commodities is more than the number of factors of production. However, the larger possibilities do not refer to different real equilibria, but only to indeterminacy in production. When demand is introduced in the economy and supply-demand equality constraints are respected, we see that factor-prices might or might not be equalized depending on factor endowments, production functions and demand. The paper demonstrates this by introducing a model with 2 countries, 2 factors of production, 3 goods and CES utility function. Finally, using comparative statistics on this simple model, the conditions under which the likelihood of factor-price equalization increases are determined.

Etude des couches de passage Couvinien-Givetien entre la vallée de l'Ourthe et la vallée de l'Aisne

This paper deals mainly with the sections in the Aisne Valley, at Rouge-Minière and Sy. A small section at Filot completes that of Sy. Certain observation could also be made in the Pont-le-Prêtre stream section, near Villers-Sainte-Gertrude and at Ferrières. These sections have allowed a better appreciation of the important variations in facies which occur near the Couvinian-Givetian boundary. This boundary has been delimited more exactly on the basis of ostracods, conodonts and corals

Quantum theory of the low-frequency linear susceptibility of interferometer-type superconducting qubits

We use the density matrix formalism to analyze the interaction of interferometer-type superconducting qubits with a high quality tank circuit, which frequency is well below the gap frequency of a qubit. We start with the ground state characterization of the superconducting flux and charge qubits. Then, by making use of a dressed state approach we describe the qubits' spectroscopy when the qubit is irradiated by a microwave field which is tuned to the gap frequency. The last section of the paper is devoted to continuous monitoring of qubit states by using a DC SQUID in the inductive mode.Comment: 11 pages, 5 figures; the title and abstract are slightly changed; several typos are corrected; in order to make our argumentation more clear we added some comments in the introduction and other section

Risk and protective factors for meningococcal disease in adolescents: matched cohort study

Objective: To examine biological and social risk factors for meningococcal disease in adolescents. Design: Prospective, population based, matched cohort study with controls matched for age and sex in 1:1 matching. Controls were sought from the general practitioner. Setting: Six contiguous regions of England, which represent some 65% of the country’s population. Participants: 15-19 year olds with meningococcal disease recruited at hospital admission in six regions (representing 65% of the population of England) from January 1999 to June 2000, and their matched controls. Methods: Blood samples and pernasal and throat swabs were taken from case patients at admission to hospital and from cases and matched controls at interview. Data on potential risk factors were gathered by confidential interview. Data were analysed by using univariate and multivariate conditional logistic regression. Results: 144 case control pairs were recruited (74 male (51%); median age 17.6). 114 cases (79%) were confirmed microbiologically. Significant independent risk factors for meningococcal disease were history of preceding illness (matched odds ratio 2.9, 95% confidence interval 1.4 to 5.9), intimate kissing with multiple partners (3.7, 1.7 to 8.1), being a university student (3.4, 1.2 to 10) and preterm birth (3.7, 1.0 to 13.5). Religious observance (0.09, 0.02 to 0.6) and meningococcal vaccination (0.12, 0.04 to 0.4) were associated with protection. Conclusions: Activities and events increasing risk for meningococcal disease in adolescence are different from in childhood. Students are at higher risk. Altering personal behaviours could moderate the risk. However, the development of further effective meningococcal vaccines remains a key public health priority

Efficient Large-scale Trace Checking Using MapReduce

The problem of checking a logged event trace against a temporal logic specification arises in many practical cases. Unfortunately, known algorithms for an expressive logic like MTL (Metric Temporal Logic) do not scale with respect to two crucial dimensions: the length of the trace and the size of the time interval for which logged events must be buffered to check satisfaction of the specification. The former issue can be addressed by distributed and parallel trace checking algorithms that can take advantage of modern cloud computing and programming frameworks like MapReduce. Still, the latter issue remains open with current state-of-the-art approaches. In this paper we address this memory scalability issue by proposing a new semantics for MTL, called lazy semantics. This semantics can evaluate temporal formulae and boolean combinations of temporal-only formulae at any arbitrary time instant. We prove that lazy semantics is more expressive than standard point-based semantics and that it can be used as a basis for a correct parametric decomposition of any MTL formula into an equivalent one with smaller, bounded time intervals. We use lazy semantics to extend our previous distributed trace checking algorithm for MTL. We evaluate the proposed algorithm in terms of memory scalability and time/memory tradeoffs.Comment: 13 pages, 8 figure

Widely tunable optical parametric oscillation in a Kerr microresonator

We report on the first experimental demonstration of widely-tunable parametric sideband generation in a Kerr microresonator. Specifically, by pumping a silica microsphere in the normal dispersion regime, we achieve the generation of phase-matched four-wave mixing sidebands at large frequency detunings from the pump. Thanks to the role of higher-order dispersion in enabling phase matching, small variations of the pump wavelength translate into very large and controllable changes in the wavelengths of the generated sidebands: we experimentally demonstrate over 720 nm of tunability using a low-power continuous-wave pump laser in the C-band. We also derive simple theoretical predictions for the phase-matched sideband frequencies, and discuss the predictions in light of the discrete cavity resonance frequencies. Our experimentally measured sideband wavelengths are in very good agreement with theoretical predictions obtained from our simple phase matching analysis.Comment: 5 pages, 4 figure