The Charitable Habits of Blood Donors

Introduction: There is a need for a constant supply of blood and blood products (e.g. plasma and platelets) in the American health care system. Common recipients of blood include: patients at risk for major hemorrhage, patients with sickle cell anemia, patients undergoing surgery, and thrombocytopenia in neonatal patients. This demand is met through nationwide blood banks, such as the American Red Cross, and their blood donation programs. The American Red Cross relies solely on volunteer donors; thus, one of the most pressing issues facing this institution is getting donors in the door. Through our survey questions we hope to uncover more factors that guide individuals in their philanthropic ways. The overall goal of this research is focused on unveiling new information that will supply the American Red Cross with valuable insight into their donor population and possible opportunities for joint publicity. We investigated the similarities and difference between how and why individuals undertake certain charitable activities.https://scholarworks.uvm.edu/comphp_gallery/1206/thumbnail.jp

La libertà incarnata. Il ruolo della persona nella presa di decisione

Riassunto: Il dibattito contemporaneo sull’impatto causale degli stati mentali e delle decisioni consce sui fenomeni naturali e sociali fa largo uso di dati ricavati da test neurofisiologici e comportamentali, che esplorano il ruolo di processi cognitivi inconsci e interpretazioni post-hoc caratterizzate da intenzionalità dichiarativa. I dati neuroscientifici sono spesso utilizzati per sostenere una prospettiva fisicalista che privilegia il determinismo neurocognitivo rispetto alle discussioni sul libero arbitrio. Tuttavia, questa impostazione tende a ignorare, almeno parzialmente, il dibattito sui limiti epistemologici e tecnici nella generazione dei dati e i pregiudizi filosofici insiti nelle interpretazioni. Questo lavoro evidenzia tali limiti, proponendo un’analisi filosofica della relazione complessa tra razionalità, esercizio del libero arbitrio e costruzione dell’identità personale. Distinguendo il concetto di scelta autentica da quello di impulso o spinta ad agire, si sostiene una concezione enattiva e fenomenologica dell’azione umana libera, offrendo così un’interpretazione del libero arbitrio che respinge l’eliminativismo come inadeguato. Rifiutando un dualismo semplicistico, il libero arbitrio viene definito come la capacità di una soggettività incarnata, situata ed enattiva di interagire con un ambiente naturale e sociale attraverso compiti che implicano processi stratificati di valutazione e decisione. In conclusione, si argomenta che, sebbene le scienze fisiche e psicologiche possano indagare le basi dell’esecuzione dell’azione, non sono in grado di risolvere né di spiegare l’aspetto più complesso del processo decisionale stratificato ed esteso. Questo riguarda la relazione intenzionale tra la persona, considerata nella sua interezza, e un mondo ricco di valori, che conferisce senso e orientamento alle scelte individuali.Parole chiave: Libertà; Persona; Cervello; Inconscio; Determinismo/Eliminativismo; Thomas Fuchs Embodied freedom. The role of person in decision-makingAbstract: The contemporary debate on the causal impact of mental states and conscious decisions on natural and social phenomena extensively relies on data derived from neurophysiological and behavioral tests. These tests investigate the role of unconscious cognitive processes and post-hoc interpretations characterized by declarative intentionality. Neuroscientific data are often employed to support a physicalist perspective that prioritizes neurocognitive determinism over discussions of free will. However, this approach tends to partially overlook the epistemological and technical limitations inherent in data generation and the philosophical biases embedded in interpretations. This paper highlights these limitations by proposing a philosophical analysis of the complex relationship between rationality, the exercise of free will, and the construction of personal identity. By distinguishing the concept of genuine choice from that of impulse or urge to act, it advocates for an enactive and phenomenological conception of human free action, offering an interpretation of free will that rejects eliminativism as inadequate. Rejecting a simplistic dualism, free will is defined as the capacity of an embodied, situated, and enactive subjectivity to engage with a natural and social environment through tasks involving layered processes of evaluation and decision-making. In conclusion, it is argued that while physical and psychological sciences may explore the foundations of action execution, they cannot resolve nor explain the more complex aspect of the stratified and extended decision-making process. This aspect concerns the intentional relationship between the person, considered as a whole, and a world rich in values, which gives meaning and direction to individual choices.Keywords: Freedom; Person; Brain; Unconscious; Determinism/Eliminativism; Thomas Fuch

Artificial Intelligence, Mathematical Modeling and Magnetic Resonance Imaging for Precision Medicine in Neurology and Neuroradiology

La tesi affronta la possibilità di utilizzare metodi matematici, tecniche di simulazione, teorie fisiche riadattate e algoritmi di intelligenza artificiale per soddisfare le esigenze cliniche in neuroradiologia e neurologia al fine di descrivere e prevedere i patterns e l’evoluzione temporale di una malattia, nonché di supportare il processo decisionale clinico. La tesi è suddivisa in tre parti. La prima parte riguarda lo sviluppo di un workflow radiomico combinato con algoritmi di Machine Learning al fine di prevedere parametri che favoriscono la descrizione quantitativa dei cambiamenti anatomici e del coinvolgimento muscolare nei disordini neuromuscolari, con particolare attenzione alla distrofia facioscapolo-omerale. Il workflow proposto si basa su sequenze di risonanza magnetica convenzionali disponibili nella maggior parte dei centri neuromuscolari e, dunque, può essere utilizzato come strumento non invasivo per monitorare anche i più piccoli cambiamenti nei disturbi neuromuscolari oltre che per la valutazione della progressione della malattia nel tempo. La seconda parte riguarda l’utilizzo di un modello cinetico per descrivere la crescita tumorale basato sugli strumenti della meccanica statistica per sistemi multi-agente e che tiene in considerazione gli effetti delle incertezze cliniche legate alla variabilità della progressione tumorale nei diversi pazienti. L'azione dei protocolli terapeutici è modellata come controllo che agisce a livello microscopico modificando la natura della distribuzione risultante. Viene mostrato come lo scenario controllato permetta di smorzare le incertezze associate alla variabilità della dinamica tumorale. Inoltre, sono stati introdotti metodi di simulazione numerica basati sulla formulazione stochastic Galerkin del modello cinetico sviluppato. La terza parte si riferisce ad un progetto ancora in corso che tenta di descrivere una porzione di cervello attraverso la teoria quantistica dei campi e di simularne il comportamento attraverso l'implementazione di una rete neurale con una funzione di attivazione costruita ad hoc e che simula la funzione di risposta del modello biologico neuronale. E’ stato ottenuto che, nelle condizioni studiate, l'attività della porzione di cervello può essere descritta fino a O(6), i.e, considerando l’interazione fino a sei campi, come un processo gaussiano. Il framework quantistico definito può essere esteso anche al caso di un processo non gaussiano, ovvero al caso di una teoria di campo quantistico interagente utilizzando l’approccio della teoria wilsoniana di campo efficace.The thesis addresses the possibility of using mathematical methods, simulation techniques, repurposed physical theories and artificial intelligence algorithms to fulfill clinical needs in neuroradiology and neurology. The aim is to describe and to predict disease patterns and its evolution over time as well as to support clinical decision-making processes. The thesis is divided into three parts. Part 1 is related to the development of a Radiomic workflow combined with Machine Learning algorithms in order to predict parameters that quantify muscular anatomical involvement in neuromuscular diseases, with special focus on Facioscapulohumeral dystrophy. The proposed workflow relies on conventional Magnetic Resonance Imaging sequences available in most neuromuscular centers and it can be used as a non-invasive tool to monitor even fine change in neuromuscular disorders and to evaluate longitudinal diseases’ progression over time. Part 2 is about the description of a kinetic model for tumor growth by means of classical tools of statistical mechanics for many-agent systems also taking into account the effects of clinical uncertainties related to patients’ variability in tumor progression. The action of therapeutic protocols is modeled as feedback control at the microscopic level. The controlled scenario allows the dumping of uncertainties associated with the variability in tumors’ dynamics. Suitable numerical methods, based on Stochastic Galerkin formulation of the derived kinetic model, are introduced. Part 3 refers to a still-on going project that attempts to describe a brain portion through a quantum field theory and to simulate its behavior through the implementation of a neural network with an ad-hoc activation function mimicking the biological neuron model response function. Under considered conditions, the brain portion activity can be expressed up to O(6), i.e., up to six fields interaction, as a Gaussian Process. The defined quantum field framework may also be extended to the case of a Non-Gaussian Process behavior, or rather to an interacting quantum field theory in a Wilsonian Effective Field theory approach

Music education employment in the State of Pennsylvania.

Thesis (M.A.)--Boston Universit

Physio-chemical quality attributes of ‘Italia’ grapes from organic and conventional farming at harvest and during storage

This study was aimed to investigate the quality at harvest and during storage of organically and conventionally grown ‘Italia’ grapes, collected from 2 different locations in Southern Italy. Four vineyards were chosen in order to have an organic and a conventional farm in each location. Before harvest, six plants per vineyard were randomly selected and considered as treatment replicate. Three bunches were harvested and labelled from each plant. In laboratory each bunch was weighed and thirty berries per bunch were detached and used for initial determination which included morphological (berry weight and dimension, peel thick-ness) and physical (berry color and firmness) attributes, maturity indices (respiration rate, soluble solids content and titratable acidity), and nutritional composition (phenol content, antioxidant activity, sugar and organic acid composition, ascorbic acid content). Then, the bunches from each replicate were kept in individual 15-L jars at 0°C and connected to a humidified air flow throughout the whole experiment. After 7 and 14 days of storage, respiration rate, weight loss, physical and nutritional attributes were also monitored on 20 berries per bunch. Location and agricultural practices affected to a different extent several grapes quality attributes, both at harvest and during storage. Maturity stage, sugar content and berry color were significantly affected by the location, while antioxidant-related compounds were significantly higher in organic grapes. Plant production and bunch weight were significantly higher for conventionally grown grapes, which also received the highest evaluation of external appearance, in terms of stalk dehydration and berry general aspect. Differences among conventional and organic grapes were maintained, for each location, during storage at 0°C. Conventional grapes maintained a higher visual quality during storage, resulting after 14 days below the limit of marketability (score 3) but above the edibility limit (score 2); whereas in one location organic grapes were judged not edible. Results showed a higher nutritional value in grapes obtained with the organic farming system although in terms of visual quali-ty, storability and yield, conventional fruit had a better performance

Cooling demand in integrated assessment models: a methodological review

The paper systematically reviews and compares 88 scenarios of energy demand in commercial and residential buildings that include the additional energy use or savings induced by thermal adaptation in heating and cooling needs at global level. The resulting studies are grouped in a novel classification that makes it possible to systematically understand why the energy projections of integrated assessment models vary depending on how changes in climatic conditions and the associated adaptation needs are modeled. Projections underestimate the energy demand of the building sector when it is driven only by income, population, unchanging climatic conditions and their associated adaptation needs. Across the studies reviewed, already by 2050 climate change will induce a median 30% (90%) percentage variation of a building's energy demand for cooling and a median -8% (-24%) percentage variation for heating, leading to a 2% (13%) increase when cooling and heating are combined, under the Representative Concentration Pathway 1.9 (8.5). The results underscore that models lacking extensive margin adjustments, and models that focus on residential demand, highly underestimate the additional cooling needs of the building sector. Topics that deserve further investigation regard improving the characterization of adopting energy-using goods that provide thermal adaptation services and better articulating the heterogeneous needs across sectors

The use of hyperspectral imaging in the visible and near infrared region to discriminate between table grapes harvested at different times

Traditional analytical methods applied to the measurement of grape maturity and quality index in order to assess optimal harvest time have been proved to be slow and destructive. Therefore, non-destructive analytical techniques, including spectroscopy, can be a valid support for the choice of the best time to harvest. This study evaluated the feasibility of using a visible and near infrared spectral scanner (v. 1.4; DV Srl, Padova, Italy) with a detector in the region between 400-1000 nm to discriminate between grapes harvested at different times. Twelve clusters were harvested at 5 different times between October and December 2011. Spectra were acquired with a Spectral scanner on 3 intact berries from each bunch. These were randomly selected from top, medium and bottom zones, for a total of 180 spectra. Classification models were construed comparing 2 methods: soft independent modelling of class analogy (SIMCA) and partial least squares discriminant analysis (PLS-DA). The SIMCA model was developed building individual principal component analysis (PCA) models for the spectra of each harvest time. Different pre-treatment methods were tested in order to enhance the power of the model, thus enhancing the score differences among samples from different harvest times. The transformation that allowed the best statistical separation among scores of grapes from different harvest times was the second derivate of Norris. Therefore, the PCA model obtained from the spectra subjected to this pre-treatment was used for SIMCA classification. The PLS-DA model were developed applying the PLS2 algorithm. In order to construct discriminant models to classify bunch spectra according to the 5 harvest times, spectral variations were correlated with the 5 categories established. No pretreatments were previously applied in this last case since they did not improve the final result. The SIMCA method was unable to correctly classify grapes from harvest time 2 (59% of correct classification) and was less efficient compared to the PLS-DA model. Using the PLS-DA model, all the grapes were correctly classified (100%) with the exception of those from harvest time 5 (94%). The overall results demonstrate that this method has excellent potential for discriminating grape quality

The effect of 1-methylcyclopropene (1-MCP) application before and after cutting on the shelflife extension of fresh-cut tomatoes

[ENG] Exposing partially ripe fruit to 1-methylcyclopropene (1-MCP) before or after cutting may be a useful supplement to proper temperature and relative humidity management for maintaining quality of fresh-cut fruit products. In this study tomato fruits were exposed to 0.5 ppm of 1-MCP for 24 hours, while tomato slices were exposed to the same concentration of 1-MCP for 6 hours. Untreated slices were used as control. Initially and after 3, 7, and 9 days of storage at 5 °C the following quality attributes were evaluated: flesh and skin color, firmness, total soluble solids content, titratable acidity and weight loss. In addition, respiration rate and ethylene production were measured. Fresh-cut tomato slices treated with 0.5 ppm of 1-MCP before cutting showed higher firmness retention than untreated slices, while slices treated after cutting showed an intermediate firmness value. Color development was delayed in both 1-MCP treated samples, which presented higher skin and flesh hue angle value compared with untreated slices. The initial decrease in skin hue angle value was reduced in slices treated either before or after cutting, while those treated after cutting showed the highest value of hue angle of the flesh. Application of 1-MCP did not affect the respiration rate, but slowed down C2H4 production in slices treated after cutting, compared to slices from untreated tomatoes. No significant effect of 1-MCP treatment was observed on titratable acidity, while for soluble solids content slices treated after cutting showed a value significantly higher than untreated slices. Application before processing resulted most effective for firmness retention, while all other effects were more visible when application followed cutting. [SPA] La exposición de tomate parcialmente maduro a 1-metilciclopropeno (1-MCP) antes o después del corte puede representar un método útil, sumado al control de la temperatura y humedad, para mantener la calidad del producto mínimamente procesado. En este estudio los tomates enteros han sido expuestos a 0,5 ppm de 1-MCP durante 24 horas, mientras las rodajas se expusieron a la misma concentración durante 6 horas. Como control se utilizaron rodajas de tomate no tratadas. Inicialmente y tras 3, 7, y 9 días de conservación a 5 ºC se evaluaron los siguientes atributos cualitativos: color (piel y pulpa), firmeza, contenido en sólidos solubles, acidez titulable y pérdida de peso. Además, se midieron la tasa respiratoria y de producción de etileno. Las rodajas de tomate tratadas con 0,5 ppm de 1-MCP antes del corte mostraron mayor mantenimiento de firmeza que las no tratadas, mientras que las rodajas tratadas después del corte han mostrado un valor intermedio de firmeza. El desarrollo del color se ha ralentizado en los dos tratamientos realizados con 1-MCP; las rodajas tratadas han mostrado un mayor valor del ángulo de tinta de la piel y de la pulpa respecto al control. La disminución inicial del ángulo de tinta de la piel se redujo en los dos tratamientos, mientras las rodajas tratadas después del corte han mostrado un mayor valor del ángulo de tinta de la pulpa. La aplicación del 1-MCP no ha afectado a la actividad respiratoria pero ha disminuido la emisión de etileno en rodajas tratadas después del corte respecto a las rodajas no tratadas con 1-MCP. No se ha observado efecto significativo del tratamiento sobre la acidez titulable, el contenido de sólidos solubles de las rodajas tratadas después del corte se ha mostrado más alto que el control. La aplicación del 1-MCP antes y después del procesado ha resultado más efectiva para el mantenimiento de la firmeza y del color, respectivamente

Ceramica d'impasto da Francavilla Marittima:ceramica grigia e altri produzioni ceramiche Circolazione di merci e modelli nella Sibaritide (e in Italia meridionale) nel'eta Ferro

Carmelo Colelli presents a study on the Iron Age impasto and grey ware pottery from excavations conducted between 1991 and 2004 and from 2009 to 2010 on the Timpone della Motta at Francavilla Marittima. In the 8th century BC the impasto appears to reflect a longstanding Oinotrian tradition having a slow morphological development that already began in the Final Bronze Age.Carmelo Colelli presents a study on the Iron Age impasto and grey ware pottery from excavations conducted between 1991 and 2004 and from 2009 to 2010 on the Timpone della Motta at Francavilla Marittima. In the 8th century BC the impasto appears to reflect a longstanding Oinotrian tradition having a slow morphological development that already began in the Final Bronze Age