Chiasma

Newspaper reporting on events at the Boston University School of Medicine in the 1960s

Conductive Cooling of SDD and SSD Front-End Chips for ALICE

We present analysis, technology developments and test results of the heat drain system of the SDD and SSD front-end electronics for the ALICE Inner Tracker System (ITS). Application of super thermoconductive carbon fibre thin plates provides a practical solution for the development of miniature motherboards for the FEE chips situated inside the sensitive ITS volume. Unidirectional carbon fibre motherboards of 160 -300 micron thickness ensure the mounting of the FEE chips and an efficient heat sink to the cooling arteries. Thermal conductivity up to 1.3 times better than copper is achieved while preserving a negligible multiple scattering contribution by the material (less than 0.15 percent of X/Xo)

Study of cosolvent-induced α-chymotrypsin fibrillogenesis: Does protein surface hydrophobicity trigger early stages of aggregation reaction?

The misfolding of specific proteins is often associated with their assembly into fibrillar aggregates, commonly termed amyloid fibrils. Despite the many efforts expended to characterize amyloid formation in vitro, there is no deep knowledge about the environment (in which aggregation occurs) as well as mechanism of this type of protein aggregation. Alpha-chymotrypsin was recently driven toward amyloid aggregation by the addition of intermediate concentrations of trifluoroethanol. In the present study, approaches such as turbidimetric, thermodynamic, intrinsic fluorescence and quenching studies as well as chemical modification have been successfully used to elucidate the underlying role of hydrophobic interactions (involved in early stages of amyloid formation) in α-chymotrypsin-based experimental system. © 2009 Springer Science+Business Media, LLC

Technical Design Report for the PANDA Solenoid and Dipole Spectrometer Magnets

This document is the Technical Design Report covering the two large spectrometer magnets of the PANDA detector set-up. It shows the conceptual design of the magnets and their anticipated performance. It precedes the tender and procurement of the magnets and, hence, is subject to possible modifications arising during this process.Comment: 10 pages, 14MB, accepted by FAIR STI in May 2009, editors: Inti Lehmann (chair), Andrea Bersani, Yuri Lobanov, Jost Luehning, Jerzy Smyrski, Technical Coordiantor: Lars Schmitt, Bernd Lewandowski (deputy), Spokespersons: Ulrich Wiedner, Paola Gianotti (deputy

Test and commissioning of the CARLOS control boards for the ALICE Silicon Drift Detectors

This paper presents the test strategy employed during the installation of the CARLOS end ladder boards developed for the Silicon Drift Detectors (SDD) of ALICE. Each CARLOS board compresses the data provided by the front-end electronics of one SDD and sends them via an optical link of 800 Mbit/s to the data concentrator card (CARLOSrx) located in the counting room. The paper describes the integration of the CARLOS boards in the final SDD system, including its cooling and mechanical support, the power supply distribution and the optical interconnections. The results of the tests performed after each step of the installation sequence are reported

Feasibility studies of time-like proton electromagnetic form factors at PANDA at FAIR

Simulation results for future measurements of electromagnetic proton form factors at \PANDA (FAIR) within the PandaRoot software framework are reported. The statistical precision with which the proton form factors can be determined is estimated. The signal channel $\bar p p \to e^+ e^-$ is studied on the basis of two different but consistent procedures. The suppression of the main background channel, $\textit{i.e.}$ $\bar p p \to \pi^+ \pi^-$, is studied. Furthermore, the background versus signal efficiency, statistical and systematical uncertainties on the extracted proton form factors are evaluated using two different procedures. The results are consistent with those of a previous simulation study using an older, simplified framework. However, a slightly better precision is achieved in the PandaRoot study in a large range of momentum transfer, assuming the nominal beam conditions and detector performance

Operation and calibration of the Silicon Drift Detectors of the ALICE experiment during the 2008 cosmic ray data taking period

The calibration and performance of the Silicon Drift Detector of the ALICE experiment during the 2008 cosmic ray run will be presented. In particular the procedures to monitor the running parameters (baselines, noise, drift speed) are detailed. Other relevant parameters (SOP delay, time-zero, charge calibration) were also determined

Impact of a dexmedetomidine intravenous infusion in septic dogs: preliminary study

Sepsis represents an increasing health emergency both in human and veterinary medicine Dexmedetomidine is an alpha-2 agonist drug with sedative and analgesic properties recently used critically ill patient in human ICU. The purpose of this work was to evaluate hemodynamics effects of a continuous infusion of dexmedetomidine in septic dogs

Dynamic analysis of artifacts: Experimental tests for the validation of numerical models

The protection of art goods is an important issue of the seismic engineering. Artifacts are of- ten made by fragile and ancient material, and they can easily present irregular shapes and high slenderness. In these years many contributions have been devoted to their analysis, based on numerical models having different complexity and computational effort. The Finite Element Models represent the most common and versatile approach for the representation of artifacts. Nevertheless, their reliability depends on the numerical assumptions made for the analysis, which requires a wide number of information regarding the dynamic behavior of the artifacts, such as the friction between the analyzed object and its support, the effective damp- ing, the inelastic involvement of material, etc. In this work an experimental campaign has been started aimed at determining the main factors which affect the dynamic representation of artifacts through FEM analysis and simplified models. A large number of experimental tests, both static and dynamic, have been performed, by adopting both real and reduced scale objects