Tiludronate and clodronate do not affect bone structure or remodeling kinetics over a 60 day randomized trial

Background Tiludronate and clodronate are FDA-approved bisphosphonate drug therapies for navicular disease in horses. Although clinical studies have determined their ability to reduce lameness associated with skeletal disorders in horses, data regarding the effect on bone structure and remodeling is lacking. Additionally, due to off-label use of these drugs in young performance horses, effects on bone in young horses need to be investigated. Therefore, the purpose of this randomized, experimental pilot study was to determine the effect of tiludronate and clodronate on normal bone cells, structure and remodeling after 60 days in clinically normal, young horses. Additionally, the effect of clodronate on bone healing 60 days after an induced defect was investigated. Results All horses tolerated surgery well, with no post-surgery lameness and all acquired biopsies being adequate for analyses. Overall, tiludronate and clodronate did not significantly alter any bone structure or remodeling parameters, as evaluated by microCT and dynamic histomorphometry. Tiludronate did not extensively impact bone formation or resorption parameters as evaluated by static histomorphometry. Similarly, clodronate did not affect bone formation or resorption after 60 days. Sixty days post-defect, healing was minimally affected by clodronate. Conclusions Tiludronate and clodronate do not appear to significantly impact bone tissue on a structural or cellular level using standard dose and administration schedules

Statistical Mechanics of 2+1 Gravity From Riemann Zeta Function and Alexander Polynomial:Exact Results

In the recent publication (Journal of Geometry and Physics,33(2000)23-102) we demonstrated that dynamics of 2+1 gravity can be described in terms of train tracks. Train tracks were introduced by Thurston in connection with description of dynamics of surface automorphisms. In this work we provide an example of utilization of general formalism developed earlier. The complete exact solution of the model problem describing equilibrium dynamics of train tracks on the punctured torus is obtained. Being guided by similarities between the dynamics of 2d liquid crystals and 2+1 gravity the partition function for gravity is mapped into that for the Farey spin chain. The Farey spin chain partition function, fortunately, is known exactly and has been thoroughly investigated recently. Accordingly, the transition between the pseudo-Anosov and the periodic dynamic regime (in Thurston's terminology) in the case of gravity is being reinterpreted in terms of phase transitions in the Farey spin chain whose partition function is just a ratio of two Riemann zeta functions. The mapping into the spin chain is facilitated by recognition of a special role of the Alexander polynomial for knots/links in study of dynamics of self homeomorphisms of surfaces. At the end of paper, using some facts from the theory of arithmetic hyperbolic 3-manifolds (initiated by Bianchi in 1892), we develop systematic extension of the obtained results to noncompact Riemannian surfaces of higher genus. Some of the obtained results are also useful for 3+1 gravity. In particular, using the theorem of Margulis, we provide new reasons for the black hole existence in the Universe: black holes make our Universe arithmetic. That is the discrete Lie groups of motion are arithmetic.Comment: 69 pages,11 figures. Journal of Geometry and Physics (in press

The role of skills from worklessness to sustainable employment with progression

This study is shaped by the recognition that while there has been a great deal of policy development around the transition from unemployment and inactivity to employment over the last decade, policy has not been sufficiently informed about how best to nurture sustainable employment for those at risk of labour market exclusion. The review focused on evidence from 2005: it provides a review of data, UK and international literature and, incorporates findings from four international case studies ( Australia, Germany, Denmark and the United States. The report provides an overview of the economic context for low pay and low skilled work and highlights the need for a continuing commitment to promoting opportunities in the labour market as a means of progression and alleviating poverty and encouraging social mobility. The report argues that there is an inextricable link between skills and ‘better jobs’. The authors conclude that a long-term view is required to decide how best to support someone at the point of worklessness: to address employability barriers in the short-term; and prepare the individual to retain, and progress in, employment. The concept of career is explored as a framework for progression: a combination of career guidance, a career / personal development plan and career management skills are identified as tools to raise aspiration and enable individual’s to take action once they are in work to support their own progression. Thinking about the workplace, the report reviews the evidence on the role of job design, line management and progression pathways in facilitating workplace learning as a route to progression

Finding Latino/a Voices in the Storytelling Process: Preservice Teachers Tell Their Stories in Digital Narratives

Preservice teachers in a bilingual education teacher preparation program created digital narratives that told their cultural stories within a sociocultural framework. The study revealed that the creation of digital stories within a sociocultural framework allowed preservice teachers to better understand their cultural heritages and unique places in society. This process allowed the preservice teachers to share their voices with audiences that they may have never considered before. Their newfound voices gave them the confidence to share with others about their identity and created a sense of belonging in their worlds in which they lived

The role of skills: from worklessness to sustainable employment with progression : UK Commission for Employment and Skills Evidence Report no. 38

This study is shaped by the recognition that while there has been a great deal of policy development around the transition from unemployment and inactivity to employment over the last decade, policy can still be informed about how best to nurture sustainable employment for those at risk of labour market exclusion. There remain challenges associated with, for example, the cost-effectiveness of intervention, the „low pay no pay‟ cycle and access to training. As a consequence, the opportunities for sustainable progression, upward social mobility and alleviating poverty remain unrealised for many workers in lower paid occupations. The methodology underpinning this study is predominantly based on a literature search and review of the research and evidence base post 2005. This is supplemented with the development of four international case studies (Australia, Denmark, Germany, United States contained in a separate annex) and an e-consultation with country experts

A New Metaheuristic Bat-Inspired Algorithm

Metaheuristic algorithms such as particle swarm optimization, firefly algorithm and harmony search are now becoming powerful methods for solving many tough optimization problems. In this paper, we propose a new metaheuristic method, the Bat Algorithm, based on the echolocation behaviour of bats. We also intend to combine the advantages of existing algorithms into the new bat algorithm. After a detailed formulation and explanation of its implementation, we will then compare the proposed algorithm with other existing algorithms, including genetic algorithms and particle swarm optimization. Simulations show that the proposed algorithm seems much superior to other algorithms, and further studies are also discussed.Comment: 10 pages, 2 figure

Micromanipulation of InP lasers with optoelectronic tweezers for integration on a photonic platform

The integration of light sources on a photonic platform is a key aspect of the fabrication of self-contained photonic circuits with a small footprint that does not have a definitive solution yet. Several approaches are being actively researched for this purpose. In this work we propose optoelectronic tweezers for the manipulation and integration of light sources on a photonic platform and report the positional and angular accuracy of the micromanipulation of standard Fabry-Pérot InP semiconductor laser die. These lasers are over three orders of magnitude bigger in volume than any previously assembled with optofluidic techniques and the fact that they are industry standard lasers makes them significantly more useful than previously assembled microdisk lasers. We measure the accuracy to be 2.5 ± 1.4 µm and 1.4 ± 0.4° and conclude that optoelectronic tweezers are a promising technique for the micromanipulation and integration of optoelectronic components in general and semiconductor lasers in particular

A Random Matrix Model of Adiabatic Quantum Computing

We present an analysis of the quantum adiabatic algorithm for solving hard instances of 3-SAT (an NP-complete problem) in terms of Random Matrix Theory (RMT). We determine the global regularity of the spectral fluctuations of the instantaneous Hamiltonians encountered during the interpolation between the starting Hamiltonians and the ones whose ground states encode the solutions to the computational problems of interest. At each interpolation point, we quantify the degree of regularity of the average spectral distribution via its Brody parameter, a measure that distinguishes regular (i.e., Poissonian) from chaotic (i.e., Wigner-type) distributions of normalized nearest-neighbor spacings. We find that for hard problem instances, i.e., those having a critical ratio of clauses to variables, the spectral fluctuations typically become irregular across a contiguous region of the interpolation parameter, while the spectrum is regular for easy instances. Within the hard region, RMT may be applied to obtain a mathematical model of the probability of avoided level crossings and concomitant failure rate of the adiabatic algorithm due to non-adiabatic Landau-Zener type transitions. Our model predicts that if the interpolation is performed at a uniform rate, the average failure rate of the quantum adiabatic algorithm, when averaged over hard problem instances, scales exponentially with increasing problem size.Comment: 9 pages, 7 figure

Nonlinear applications in the mid-infrared regime based on germanium on silicon platform

This abstract reviews our progress in characterizing nonlinear properties of low loss germanium-on-silicon waveguides in the mid-infrared wavelength. All-optical modulation is demonstrated in these waveguides and indicates the suitability of this platform for nonlinear applications in this long wavelength regime