‘Let the Muslim be my Master in Outward Things’. References to Islam in the Promotion of Religious Tolerance in Christian Europe

Islam presents a policy of religious tolerance, rooted in teachings on the universal nature of man, his free relationship to God, and the divine origins of other religions. The prophet Muhammadsa separated his authority as a religious leader from his position as a governor, creating a religiously diverse society from the very start. This contrasted to the Christian world, where men were regarded to be born in original sin, only to be redeemed by Christ through the one true Church. Ever since the Byzantine Empire, Christian rulers had governed by the motto ‘One State, One Law, One Faith’, leading to horrendous persecutions of heretics. Throughout history, persecuted Christians have noticed the contrast to the tolerance within Islam. When, in the 16th century, persecutions in Europe became unbearable, Christian advocates of tolerance referred to the Ottoman Empire as the model to adopt. The example of the empire was offered in debates on tolerance from Hungary to Germany, France, the Netherlands and Great Britain, up until the 18th century, by tolerance advocates such as Sebastian Castellio, Francis Junius, John Locke and Voltaire. The Netherlands became a junction, adopting not only the Ottoman model of religious diversity, but also receiving political and military support from Ottoman sultans.British Academ

Rhazes in the Renaissance of Andreas Vesalius

Andreas Vesalius' (1514–64) first publication was a Paraphrasis of the ninth book of the Liber ad Almansorem, written by the Arab–Persian physician and alchemist Rhazes (854–925). The role of Rhazes in Vesalius' oeuvre has thus far been much disregarded. The different ways Rhazes recurs reveal an intellectual evolution in Vesalius' work. In the Paraphrasis, Vesalius subjects Rhazes to the authority of Galen in the context of the early sixteenth-century humanist campaign for the substitution of Arab influences by Greek ‘originals’. Over the years Vesalius continues his work on Rhazes, but his approach becomes more internationalistic. Ultimately, Vesalius criticises Galen while expressing sympathy for the Arab author. This may be the more significant as Rhazes could have influenced Vesalius in the act of criticising Galen – critical discussions of Galen were available to Vesalius in Latin translations of Rhazes's Liber Continens. Although Vesalius never refers to the work, it is hardly possible he was unaware of it: similarities in structure, rhetoric and form between the Continens and the De humani corporis fabrica could support this hypothesis

Atrial fibrillation ablation : balancing between treatment efficacy and complications

The results of this thesis acknowledge one of the major contemporary problems in AF treatment, which is to find the optimal balance between ablation efficacy and related potential complications. A higher efficacy may be obtained by a more invasive ablation strategy, while this type of procedure also seems to increase the risk for complications. On the other hand, simplifying the procedure with a so-called single-shot device can also lead to an increased complication rate. Therefore, optimization of procedures with currently available catheters may be the best strategy to achieve a highly effective procedure for patients with paroxysmal or even persistent AF, without leading to significant complications. A minimally invasive strategy may be suitable for patients with (longstanding) persistent AF, especially if these patients have no comorbidities that require open heart surgery. The studies described in this thesis contributed to further elucidating the feasibility and potential risks of performing new ablation procedures and catheters. This may contribute to optimize AF ablation procedures. LUMC / Geneeskund

Child maltreatment : underlying risk factors and perspectives of parents and children

Knowledge of risk factors associated with child maltreatment is critical in assessing the risk for future child maltreatment, and for preventing child maltreatment. Using data from two empirical studies, this dissertation focuses on the risk associated with having experienced childhood maltreatment and on emotion processing deficits as a risk factor. Additionally, because accurately measuring maltreatment experiences is important, we explored the relation between parents’ and children’s perspectives on maltreatment. Results revealed that there was modest agreement between parents and children on parent-to-child maltreatment, especially on emotional neglect. On average, children reported more emotional neglect as victims than parents as perpetrators. Next, we found evidence for type-to-type intergenerational transmission of maltreatment: Abused parents were more likely to abuse their own children, while neglected parents were more likely to neglect. Moreover, neglecting parents showed difficulties identifying fear in others, but this could not explain the intergenerational transmission of maltreatment. Lastly, maltreating mothers used excessive force more often while listening to infant crying and laughter than non-maltreating mothers. Overall, maltreating parents –and neglectful parents in particular– seem less adept in emotion processing: They were less successful in regulating their behavior when exposed to child-related emotional stimuli and showed specific difficulties in emotion recognition.  Development Psychopathology in context: famil

An intergenerational family study on the impact of experienced and perpetrated child maltreatment on neural face processing

Altered processing of emotional faces due to childhood maltreatment has repeatedly been reported, and may be a key process underlying the intergenerational transmission of maltreatment. The current study is the first to examine the role of neural reactivity to emotional and neutral faces in the transmission of maltreatment, using a multi-generational family design including 171 participants of 51 families of two generations with a large age range (8–69 years). The impact of experienced and perpetrated maltreatment (abuse and neglect) on face processing was examined in association with activation in the amygdala, hippocampus, inferior frontal gyrus (IFG) and insula in response to angry, fearful, happy and neutral faces. Results showed enhanced bilateral amygdala activation in response to fearful faces in older neglected individuals, whereas reduced amygdala activation was found in response to these faces in younger neglected individuals. Furthermore, while experienced abuse was associated with lower IFG activation in younger individuals, experience of neglect was associated with higher IFG activation in this age group, pointing to potentially differential effects of abuse and neglect and significant age effects. Perpetrated abusive and neglectful behavior were not related to neural activation in any of these regions. Hence, no indications for a role of neural reactivity to emotional faces in the intergenerational transmission of maltreatment were found.Stress and Psychopatholog

Attachment representations and autonomic regulation in maltreating and nonmaltreating mothers.

This study assessed attachment representation and attachment-related autonomic regulation in a sample of 38 maltreating and 35 nonmaltreating mothers. Mothers' state of mind regarding attachment was measured using the Adult Attachment Interview. They further watched an attachment-based comfort paradigm, during which we measured skin conductance and vagal tone. More maltreating mothers (42%) than nonmaltreating mothers (17%) had an unresolved/disoriented attachment classification. Attachment representation was related to physiology during the comfort paradigm: an unresolved state of mind and a nonautonomous classification were associated with a decrease in skin conductance during the comfort paradigm, specifically during the responsive caregiver scenario. However, physiology did not differ between maltreating and nonmaltreating mothers. The decrease in skin conductance of unresolved mothers during the comfort paradigm might be indicative of a deactivating response, which is congruent with the dissociative nature of the unresolved state of mind. The results point to the potential utility of interventions focused on attachment representations for maltreating mothers.The study was supported by Yulius mental health clinic, the Netherlands Organization for Scientific Research (MHvIJ: NWO SPINOZA prize; MJBK: VICI grant; LRAA: VIDI grant), and the Wellcome Trust (WT103343MA).This is the author accepted manuscript. The final version is available from Cambridge University Press via https://doi.org/10.1017/S095457941600103

Parents’ experiences of childhood abuse and neglect are differentially associated with behavioral and autonomic responses to their offspring

Although childhood maltreatment has been shown to compromise adaptive parental behavior, little is known what happens in terms of physiological regulation when parents with a history of childhood maltreatment interact with their offspring. Using a sample of 229 parents (131 women), the present study examined whether childhood maltreatment experiences are associated with parents’ behavioral and autonomic responses while resolving conflict with their offspring. Self‐reported experienced child maltreatment was measured using a questionnaire assessing abuse and neglect. Parents (Mage = 52.7 years, rangeage = 26.6–88.4 years) and their offspring (Mage = 24.6 years, rangeage = 7.5–65.6 years) participated in a videotaped parent–offspring conflict interaction task. Parental warmth, negativity, and emotional support were coded. In addition, their pre‐ejection period and respiratory sinus arrhythmia were measured as indicators of underlying sympathetic and parasympathetic nervous system reactivity, respectively. Findings demonstrated that experiences of abuse and neglect were associated with behavioral and physiological responses in different ways. Separating these two types of maltreatment in research and in clinical practice might be important

Not the Root of the Problem-Hair Cortisol and Cortisone Do Not Mediate the Effect of Child Maltreatment on Body Mass Index.

BACKGROUND: Experiencing maltreatment during childhood exerts substantial stress on the child and increases the risk for overweight and obesity later in life. The current study tests whether hair cortisol-a measure of chronic stress-and its metabolite cortisone mediate the relation between abuse and neglect on the one hand, and body mass index (BMI) on the other. METHOD: The sample consisted of 249 participants aged 8 to 87 years (M = 36.13, SD = 19.33). We collected data on child abuse and neglect using questionnaires, measured cortisol and cortisone concentrations in hair, and BMI. In a structural model, the effects of abuse and neglect on hair cortisol, hair cortisone, and BMI were tested, as well as the covariance between hair cortisol and BMI, and hair cortisone and BMI. RESULTS: Within the sample, 23% were overweight but not obese and 14% were obese. Higher levels of experienced abuse were related to higher cortisone concentrations in hair (β = 0.24, p < .001) and higher BMI (β = 0.17, p =.04). Neglect was not related to hair cortisol, hair cortisone, or BMI. Hair cortisol and cortisone did not mediate the association between maltreatment, and BMI. Sensitivity analyses demonstrate the same pattern of results in a subsample of adult participants currently not living with their parents. However, in younger participants who were still living with their parents, the associations between abuse and cortisone (β = 0.14, p =.35) and abuse and BMI (β = 0.02, p =.92) were no longer significant. CONCLUSION: These findings confirm that experiencing abuse is related to higher BMI but suggest that hair cortisol and cortisone are not the mechanism underlying the association between child maltreatment and BMI. This is the first study to show abuse may be associated to elevated concentrations of hair cortisone-evidence of long-term alterations in chronic stress levels. Future research may benefit from exploring the effects of maltreatment on weight gain in longitudinal designs, including measures of other potential mediators such as eating as a coping mechanism, and more direct indicators of metabolic health

Not the Root of the Problem—Hair Cortisol and Cortisone Do Not Mediate the Effect of Child Maltreatment on Body Mass Index

Background: Experiencing maltreatment during childhood exerts substantial stress on the child and increases the risk for overweight and obesity later in life. The current study tests whether hair cortisol—a measure of chronic stress—and its metabolite cortisone mediate the relation between abuse and neglect on the one hand, and body mass index (BMI) on the other. Method: The sample consisted of 249 participants aged 8 to 87 years (M = 36.13, SD = 19.33). We collected data on child abuse and neglect using questionnaires, measured cortisol and cortisone concentrations in hair, and BMI. In a structural model, the effects of abuse and neglect on hair cortisol, hair cortisone, and BMI were tested, as well as the covariance between hair cortisol and BMI, and hair cortisone and BMI. Results: Within the sample, 23% were overweight but not obese and 14% were obese. Higher levels of experienced abuse were related to higher cortisone concentrations in hair (β = 0.24, p <.001) and higher B