Secondary organizing pneumonia (bronchiolitis obliterans with organizing pneumonia) associated with adalimumab for treatment of chronic plaque psoriasis

Organizing pneumonia is defined histopathologically by intra-alveolar buds of granulation tissue, consisting of intermixed myofibroblasts and connective tissue. The pathological pattern of organizing pneumonia may be idiopathic or related to a determined cause, termed secondary organizing pneumonia. We report a 68-year-old woman with a longstanding history of chronic plaque psoriasis, treated with the tumor necrosis factor (TNF) inhibitor, adalimumab. After 8 years of treatment, she developed a gradual-onset, non-productive cough with associated generalized fatigue and mild dyspnea. Radiological investigations demonstrated ground-glass opacities in the left lower lobe and bronchoscopy revealed a fibroinflammatory process consistent with organizing pneumonia. Her biologic treatment was ceased and corticosteroid treatment commenced, with resolution of both her symptoms and the radiological findings. Given the increasing incidence of biologic treatment in the management of dermatological conditions, clinicians should be aware of secondary organizing pneumonia as a possible side effect of TNF inhibitor therapy

Hot-Wire Measurements of Transverse Vortices. Aerospace Engineering Report 9830

This is a report to document a series of tests performed using the new transverse vortex generator rig in the 1.15 m x 0.85 m wind tunnel. Results were acquired with a hot wire anemometer system using single and cross wire probes. A strong vortex velocity field was measured which confirmed the success of the vortex generation technique and provided information about the gross features of the flow. The data indicated that an interaction occurred between the vortex core and the hot wire probe. This interaction manifested itself as variations in vortex core measurements which one would not expect without probe interference. While an interaction was present when measuring close to the core region, outside the core region the probe had little effect on vortex dynamics. This allowed analysis of vortex geometry and an estimation of the vortex wandering amplitude in the test section. Mechanisms of vortex/probe interaction were also considered and are discussed in the report. Wake curvature was measured using differently spaced single and cross wire probes. This data was compared with a computational model of the vortex generator wake and shows good agreement

Hot-Wire Measurements of Transverse Vortices. Aerospace Engineering Report 9830

This is a report to document a series of tests performed using the new transverse vortex generator rig in the 1.15 m x 0.85 m wind tunnel. Results were acquired with a hot wire anemometer system using single and cross wire probes. A strong vortex velocity field was measured which confirmed the success of the vortex generation technique and provided information about the gross features of the flow. The data indicated that an interaction occurred between the vortex core and the hot wire probe. This interaction manifested itself as variations in vortex core measurements which one would not expect without probe interference. While an interaction was present when measuring close to the core region, outside the core region the probe had little effect on vortex dynamics. This allowed analysis of vortex geometry and an estimation of the vortex wandering amplitude in the test section. Mechanisms of vortex/probe interaction were also considered and are discussed in the report. Wake curvature was measured using differently spaced single and cross wire probes. This data was compared with a computational model of the vortex generator wake and shows good agreement

Design and construction of the X-2 two-stage free piston driven expansion tube

This report outlines the design and construction of the X-2 two-stage free piston driven expansion tube. The project has completed its construction phase and the facility has been installed in the new impulsive research laboratory where commissioning is about to take place. The X-2 uses a unique, two-stage driver design which allows a more compact and lower overall cost free piston compressor. The new facility has been constructed in order to examine the performance envelope of the two-stage driver and how well it couple to sub-orbital and super-orbital expansion tubes. Data obtained from these experiments will be used for the design of a much larger facility, X-3, utilizing the same free piston driver concept

Experimental investigation of airfoil-turbulence interaction noise

Airfoil-turbulence-interaction noise, which is created whenever turbulent flow encounters an airfoil, is a major contributor of unwanted noise emitted by aircraft, turbomachinery and alike. The experimental study presented here is the precursor to a larger investigation of the impact of complex turbulence on noise generation at the airfoil's leading-edge and airfoil-wall junction. In the current study, the authors examine links between the experimentally acquired properties of isotropic turbulence and the sound radiation of the immersed airfoil. This is achieved by varying the in-flow turbulence intensity using two different turbulence grids. A NACA0012 airfoil was analysed at a range of geometric angles of attack up to 16 degrees and Reynolds numbers of 1 ∙ 105 up to 3 ∙ 105. Stereoscopic Particle Image Velocimetry (SPIV) was conducted beforehand to capture the turbulence characteristics of the free flow. Additionally, acoustic beamforming with a phased microphone array provides insight into the sound generation at the leading-edge. Pressure taps along the centre chord-line were used to measure the mean static pressure, thereby allowing for an open-jet deflection correction of the angle of attack