Simultaneous optical and radio observations of NP 0532

Simultaneous optical and radio observations of Crab Nebula pulsar NP 0532 and time delay analysi

The Constitutional Prism of Louis-Philippe Pigeon and Jean Beetz

Après avoir expliqué ce qu'il entend par notion de constitution (“image of a constitution”, l'auteur examine les écrits judiciaires et doctrinaux des juges Pigeon et Beetz dans le but de voir quelle idée l'un et l'autre se faisaient de ce qu'est une constitution. Ces écrits, selon lui, se fondent sur des conceptions articulées du rôle des textes comme source du droit, du rôle des normes comme prétention de départ de l'analyse constitutionnelle, du rôle scientifique du juriste et, enfin, des positions respectives des différentes règles de droit. L'auteur conclut que cette façon de voir s'inscrit à l'intérieur d'une conception globale du droit dont les tenants et aboutissants n'ont jamais été vraiment étudiés.After introducing the concept of an "image of a constitution", Mr Conklin examines the federalism writings and judgments of Justices Pigeon and Beetz with a view to identifying the bounderies of their respective concepts of a constitution. He argues that their writings presuppose coherent answers to such boundaries as the role of a text as the primary source of law, the posited character of rules, rules as the starting point of constitutional analysis, the scientistic role of a lawyer, and a horizontal / vertical spectrum of posited rules. Mr. Conklin claims that their understanding of law collapses into a more primordial image of law whose boundaries we have for too long left unexamined

Chaos For the Halibut?

A generalized method for analyzing stability potential in discrete time renewable resource models subject to market-driven harvest is discussed. Two means by which harvest activity can influence dynamical properties of renewable resource models are identified: the "growth factor" and the "market response effect". The growth factor is a systematic influence on stability tied to changes in the position of the bioeconomic equilibrium point along a given open access supply locus. The market response effect involves variation in harvest in response to stock level changes. The analysis is applied to a model of the Pacific Halibut Fishery: a modified discrete-time version of the traditional Schaefer model. In order to investigate potential instability, we vary certain parameters of the model and study the resulting effects on stability. We find that enhancing harvest response by changing the slope of the demand schedule can thrust the model into instability, chaos, and extinction, without changing the bioeconomic equilibrium point for the Pacific Halibut Fishery Model. We also show that enhancing harvest response via slope preserving increases in market demand can push the model into instability, chaos, and even extinction. Finally, we show that similar adjustments in market demand may be capable of eliminating instability and chaos rooted in powerful intrinsic growth of the stockStability Analysis, Chaos, Open-Access Fisheries, Renewable Resource Models., Environmental Economics and Policy, Production Economics,

Spatially distributed water-balance and meteorological data from the Wolverton catchment, Sequoia National Park, California

Accurate water-balance measurements in the seasonal, snow-dominated Sierra Nevada are important for forest and downstream water management. However, few sites in the southern Sierra offer detailed records of the spatial and temporal patterns of snowpack and soil-water storage and the fluxes affecting them, i.e., precipitation as rain and snow, snowmelt, evapotranspiration, and runoff. To explore these stores and fluxes we instrumented the Wolverton basin (2180-2750 m) in Sequoia National Park with distributed, continuous sensors. This 2006-2016 record of snow depth, soil moisture and soil temperature, and meteorological data quantifies the hydrologic inputs and storage in a mostly undeveloped catchment. Clustered sensors record lateral differences with regards to aspect and canopy cover at approximately 2250 and 2625 m in elevation, where two meteorological stations are installed. Meteorological stations record air temperature, relative humidity, radiation, precipitation, wind speed and direction, and snow depth. Data are available at hourly intervals by water year (1 October-30 September) in non-proprietary formats from online data repositories (https://doi.org/10.6071/M3S94T)

Enhanced Integrin α4β1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes.

Diabetes is associated with a deficit of circulating endothelial progenitor cells (EPCs), which has been attributed to their defective mobilization from the bone marrow. The basis for this mobilization defect is not completely understood, and we sought to determine if hyperglycemic conditions enhanced EPC adhesion. We found that culturing EPCs in high glucose media increased adhesion to bone marrow stromal cells. This enhanced adhesion was associated with decreased expression of protein kinase A regulatory subunit 1β (PRKAR1β), activation of protein kinase A (PKA), and phosphorylation of α4-integrin on serine 988. This potentiated adhesion was reversed by treatment with a PKA inhibitor, overexpression of PRKAR1β, or expression of a phosphorylation-defective α4-integrin variant (α4[S988A]). Using a model of type 1 diabetes, we showed that α4(S988A)-expressing mice have more circulating EPCs than their wild-type counterparts. Moreover, diabetic α4(S988A) mice demonstrate enhanced revascularization after hind limb ischemia. Thus, we have identified a novel signaling mechanism activating PKA in diabetes (downregulation of an inhibitory regulatory subunit) that leads to deficits of circulating EPCs and impaired vascular repair, which could be reversed by α4-integrin mutation

How Farm Families Make Decisions

A.E. Res. 79-

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload.

The integration of in vitro cardiac tissue models, human induced pluripotent stem cells (hiPSCs) and genome-editing tools allows for the enhanced interrogation of physiological phenotypes and recapitulation of disease pathologies. Here, using a cardiac tissue model consisting of filamentous three-dimensional matrices populated with cardiomyocytes derived from healthy wild-type (WT) hiPSCs (WT hiPSC-CMs) or isogenic hiPSCs deficient in the sarcomere protein cardiac myosin-binding protein C (MYBPC3-/- hiPSC-CMs), we show that the WT microtissues adapted to the mechanical environment with increased contraction force commensurate to matrix stiffness, whereas the MYBPC3-/- microtissues exhibited impaired force development kinetics regardless of matrix stiffness and deficient contraction force only when grown on matrices with high fibre stiffness. Under mechanical overload, the MYBPC3-/- microtissues had a higher degree of calcium transient abnormalities, and exhibited an accelerated decay of calcium dynamics as well as calcium desensitization, which accelerated when contracting against stiffer fibres. Our findings suggest that MYBPC3 deficiency and the presence of environmental stresses synergistically lead to contractile deficits in cardiac tissues