Optical Excitation of Surface Plasmon Polaritons on Novel Bigratings

This thesis details original experimental investigations in to the interaction of light with the mobile electrons at the surface of metallic diffraction gratings. The gratings used in this work to support the resultant trapped surface waves (surface plasmon polaritons), may be divided into two classes: ‘crossed’ bigratings and ‘zigzag’ gratings. Crossed bigratings are composed of two diffraction gratings formed of periodic grooves in a metal surface, which are crossed at an angle relative to one another. While crossed bigratings have been studied previously, this work focuses on symmetries which have received comparatively little attention in the literature. The gratings explored in this work possesses two different underlying Bravais lattices: rectangular and oblique. Control over the surface plasmon polariton (SPP) dispersion on a rectangular bigrating is demonstrated by the deepening of one of the two constituent gratings. The resulting change in the diffraction efficiency of the surface waves leads to large SPP band-gaps in one direction across the grating, leaving the SPP propagation in the orthogonal direction largely unperturbed. This provides a mechanism to design surfaces that support highly anisotropic propagation of SPPs. SPPs on the oblique grating are found to mediate polarisation conversion of the incident light field. Additionally, the SPP band-gaps that form on such a surface are shown to not necessarily occur at the Brillouin Zone boundaries of this lattice, as the BZ boundary for an oblique lattice is not a continuous contour of high-symmetry points. The second class of diffraction grating investigated in this thesis is the new zigzag grating geometry. This grating is formed of sub-wavelength (non-diffracting) grooves that are ‘zigzagged’ along their length to provide a diffractive periodicity for visible frequency radiation. The excitation and propagation of SPPs on such gratings is investigated and found to be highly polarisation selective. The first type of zigzag grating investigated possesses a single mirror plane. SPP excitation to found to be dependant on which diffracted order of SPP is under polarised illumination. The formation of SPP band-gaps is also investigated, finding that the band-gap at the first Brillouin Zone boundary is forbidden by the grating’s symmetry. The final grating considered is a zigzag grating which possesses no mirror symmetry. Using this grating, it is demonstrated that any polarisation of incident light may resonantly drive the same SPP modes. SPP propagation on this grating is found to be forbidden in all directions for a range of frequencies, forming a full SPP band-gap.EPSRCHP Labs (Bristol

Intensity dependences of the nonlinear optical excitation of plasmons in graphene

Recently, we demonstrated an all-optical coupling scheme for plasmons, which takes advantage of the intrinsic nonlinear optical response of graphene. Frequency mixing using free-space, visible light pulses generates surface plasmons in a planar graphene sample, where the phase matching condition can define both the wavevector and energy of surface waves and intraband transitions. Here, we also show that the plasmon generation process is strongly intensity-dependent, with resonance features washed out for absorbed pulse fluences greater than 0.1 J m−2. This implies a subtle interplay between the nonlinear generation process and sample heating. We discuss these effects in terms of a non-equilibrium charge distribution using a two-temperature model.Peer ReviewedPostprint (author's final draft

Report No. 16: Study on the Social and Labour Market Integration of Ethnic Minorities

Report for the High Level Advisory Group on Social and Labour Market Integration of Ethnic Minorities and the European Commission, Bonn 2008 (166 pages) [German version] (Studie über die soziale Eingliederung und Arbeitsmarktintegration ethnischer Minderheiten)

Pharmacokinetics, safety, and efficacy of a single co-administered dose of diethylcarbamazine, albendazole and ivermectin in adults with and without Wuchereria bancrofti infection in Cote d\u27Ivoire

BackgroundA single co-administered dose of ivermectin (IVM) plus diethylcarbamazine (DEC) plus albendazole (ALB), or triple-drug therapy, was recently found to be more effective for clearing microfilariae (Mf) than standard DEC plus ALB currently used for mass drug administration programs for lymphatic filariasis (LF) outside of sub-Saharan Africa. Triple-drug therapy has not been previously tested in LF-uninfected individuals from Africa. This study evaluated the pharmacokinetics (PK), safety, and efficacy of triple-drug therapy in people with and without Wuchereria bancrofti infection in West Africa.MethodsIn this open-label cohort study, treatment-naïve microfilaremic (>50 mf/mL, n = 32) and uninfected (circulating filarial antigen negative, n = 24) adults residing in Agboville district, Côte d’Ivoire, were treated with a single dose of IVM plus DEC plus ALB, and evaluated for adverse events (AEs) until 7 days post treatment. Drug levels were assessed by liquid chromatography and mass spectrometry. Persons responsible for assessing AEs were blinded to participants’ infection status.FindingsThere was no difference in AUC0-inf or Cmax between LF-infected and uninfected participants (P>0.05 for all comparisons). All subjects experienced mild AEs; 28% and 25% of infected and uninfected participants experienced grade 2 AEs, respectively. There were no severe or serious adverse events. Only fever (16 of 32 versus 4 of 24, PConclusionsModerate to heavy W. bancrofti infection did not affect PK parameters for IVM, DEC or ALB following a single co-administered dose of these drugs compared to uninfected individuals. The drugs were well tolerated. This study confirmed the efficacy of the triple-drug therapy for clearing W. bancrofti Mf and has added important information to support the use of this regimen in LF elimination programs in areas of Africa without co-endemic onchocerciasis or loiasis.Trial registrationClinicalTrials.gov NCT02845713.</div

Surface plasmons at the Brillouin zone boundary of an oblique lattice

Copyright © 2015 AIP PublishingIn periodic systems of low-symmetry, the Bragg condition for the complete interference of waves along the contour of the Brillouin zone (BZ) boundary is not generally satisfied. As a result, band-gaps do not necessarily occur at this boundary. This letter demonstrates this experimentally by recording the iso-frequency contours for surface plasmon polaritons (SPPs) supported on a diffraction grating with an underlying 2D oblique Bravias lattice. It is shown that these contours do not intersect the BZ boundary perpendicularly, as the symmetry operations of the lattice place no conditions on the surface wave interference at this boundary.Engineering and Physical Sciences Research Council (EPSRC)HP Labs BristolUSA

Adhesion force imaging in air and liquid by adhesion mode atomic force microscopy

A new imaging mode for the atomic force microscope(AFM), yielding images mapping the adhesion force between tip and sample, is introduced. The adhesion mode AFM takes a force curve at each pixel by ramping a piezoactuator, moving the silicon‐nitride tip up and down towards the sample. During the retrace the tip leaves the sample with an adhesion dip showing up in the force curve. Adhesion force images mapping parameters describing this adhesion dip, such as peak value, width, and area, are acquired on‐line together with the sample topography. Imaging in air gives information on the differences in hydrophobicity of sample features. While imaging a mercaptopentadecane‐gold layer on glass in demineralized water, the adhesion force could be modulated by adding phosphate buffered saline

Light pollution is associated with earlier tree budburst across the United Kingdom

ArticleThe ecological impact of night-time lighting is of concern because of its well-demonstrated effects on animal behaviour. However, the potential of light pollution to change plant phenology and its corresponding knock-on effects on associated herbivores are less clear. Here, we test if artificial lighting can advance the timing of budburst in trees. We took a UK-wide 13 year dataset of spatially referenced budburst data from four deciduous tree species and matched it with both satellite imagery of night-time lighting and average spring temperature. We find that budburst occurs up to 7.5 days earlier in brighter areas, with the relationship being more pronounced for later-budding species. Excluding large urban areas from the analysis showed an even more pronounced advance of budburst, confirming that the urban ‘heat-island’ effect is not the sole cause of earlier urban budburst. Similarly, the advance in budburst across all sites is too large to be explained by increases in temperature alone. This dramatic advance of budburst illustrates the need for further experimental investigation into the impact of artificial night-time lighting on plant phenology and subsequent species interactions. As light pollution is a growing global phenomenon, the findings of this study are likely to be applicable to a wide range of species interactions across the world.R.S.-Y. was supported by a GWR-ESF Studentship awarded by the University of Exeter to R.H.f.-C. The study was also founded by a BBSRC grant to R.H.f-C

Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen burkholderia pseudomallei K96243

Burkholderia pseudomallei is an important human pathogen whose infection biology is still poorly understood. The bacterium is endemic to tropical regions, including South East Asia and Northern Australia, where it causes melioidosis, a serious disease associated with both high mortality and antibiotic resistance. B. pseudomallei is a Gram-negative facultative intracellular pathogen that is able to replicate in macrophages. However despite the critical nature of its interaction with macrophages, few anti-macrophage factors have been characterized to date. Here we perform a genome-wide gain of function screen of B. pseudomallei strain K96243 to identify loci encoding factors with anti-macrophage activity. We identify a total of 113 such loci scattered across both chromosomes, with positive gene clusters encoding transporters and secretion systems, enzymes/toxins, secondary metabolite, biofilm, adhesion and signal response related factors. Further phenotypic analysis of four of these regions shows that the encoded factors cause striking cellular phenotypes relevant to infection biology, including apoptosis, formation of actin ‘tails’ and multi-nucleation within treated macrophages. The detailed analysis of the remaining host of loci will facilitate genetic dissection of the interaction of this important pathogen with host macrophages and thus further elucidate this critical part of its infection cycle