433 research outputs found

    Canonical Analysis of the Jackiw-Teitelboim Model in the Temporal Gauge. I. The Classical Theory

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    As a preparation for its quantization in the loop formalism, the 2-dimensional gravitation model of Jackiw and Teitelboim is analysed in the classical canonical formalism. The dynamics is of pure constraints as it is well-known. A partial gauge fixing of the temporal type being performed, the resulting second class constraints are sorted out and the corresponding Dirac bracket algebra is worked out. Dirac observables of this classical theory are then calculated.Comment: 15 pages, Latex. Misprint correction

    ‘Together … for only a moment’ British newspaper constructions of altruistic non-commercial surrogate motherhood

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    Objectives: To explore how national altruistic surrogacy is framed in a representative selection of the British press. Methods: A study of 90 British national newspaper articles was carried out using the Lexis-Nexis data base to search for articles on altruistic surrogacy. Content analysis of gain, loss, neutral frames and high or low alarm and vulnerability frames in the titles and the body of the text was carried out. The type of construction used in the article content was also analysed. Data were coded and consensus reached using a coding strategy specifically developed for the purposes of this study. Results: Titles and content were predominantly loss, high alarm and high vulnerability framed. The content was also gain framed, and written with a focus on the social and legal aspects differentially between the newspaper types. Discussion: The tabloid press emphasizes social issues, and the middle market and serious press focus on legal issues of altruistic surrogacy. Selectively framed and reinforced information provided by the different newspapers, reflect the different readership, with Tabloid readers likely to be, surrogates (mostly from lower socioeconomic strata) and serious/ middle-market readers likely to be commissioning parents (mostly professionals)

    Symmetries of topological field theories in the BV-framework

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    Topological field theories of Schwarz-type generally admit symmetries whose algebra does not close off-shell, e.g. the basic symmetries of BF models or vector supersymmetry of the gauge-fixed action for Chern-Simons theory (this symmetry being at the origin of the perturbative finiteness of the theory). We present a detailed discussion of all these symmetries within the algebraic approach to the Batalin-Vilkovisky formalism. Moreover, we discuss the general algebraic construction of topological models of both Schwarz- and Witten-type.Comment: 30 page

    On anomalies in classical dynamical systems

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    The definition of "classical anomaly" is introduced. It describes the situation in which a purely classical dynamical system which presents both a lagrangian and a hamiltonian formulation admits symmetries of the action for which the Noether conserved charges, endorsed with the Poisson bracket structure, close an algebra which is just the centrally extended version of the original symmetry algebra. The consistency conditions for this to occur are derived. Explicit examples are given based on simple two-dimensional models. Applications of the above scheme and lines of further investigations are suggested.Comment: arXiv version is already officia

    Demixed principal component analysis of neural population data

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    Neurons in higher cortical areas, such as the prefrontal cortex, are often tuned to a variety of sensory and motor variables, and are therefore said to display mixed selectivity. This complexity of single neuron responses can obscure what information these areas represent and how it is represented. Here we demonstrate the advantages of a new dimensionality reduction technique, demixed principal component analysis (dPCA), that decomposes population activity into a few components. In addition to systematically capturing the majority of the variance of the data, dPCA also exposes the dependence of the neural representation on task parameters such as stimuli, decisions, or rewards. To illustrate our method we reanalyze population data from four datasets comprising different species, different cortical areas and different experimental tasks. In each case, dPCA provides a concise way of visualizing the data that summarizes the task-dependent features of the population response in a single figure

    Construction of nonsingular cosmological solutions in string theories

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    We study nonsingular cosmological scenarios in a general DD-dimensional string effective action of the dilaton-modulus-axion system in the presence of the matter source. In the standard dilatonic Brans-Dicke parameter (ω=1\omega=-1) with radiation, we analytically obtain singularity-free bouncing solutions where the universe starts out in a state with a finite curvature and evolves toward the weakly coupled regime. We apply this analytic method to the string-gas cosmology including the massive state in addition to the leading massless state (radiation), with and without the axion. We numerically find bouncing solutions which asymptotically approach an almost radiation-dominant universe with a decreasing curvature irrespective of the presence of the axion, implying that inclusion of the matter source is crucial for the existence of such solutions for ω=1\omega=-1. In the theories with ω1\omega \ne -1, it is possible to obtain complete regular bouncing solutions with a finite dilaton and curvature in both past and future asymptotics for the general dimension, DD. We also discuss the case where dilatonic higher-order corrections are involved to the tree-level effective action and demonstrate that the presence of axion/modulus fields and the matter source does not significantly affect the dynamics of the dilaton-driven inflation and the subsequent graceful exit.Comment: 27 pages, 6 eps figure

    Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells

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    In the prefrontal cortex, parvalbumin-positive inhibitory neurons play a prominent role in the neural circuitry that subserves working memory, and alterations in these neurons contribute to the pathophysiology of schizophrenia. Two morphologically distinct classes of parvalbumin neurons that target the perisomatic region of pyramidal neurons, chandelier cells (ChCs) and basket cells (BCs), are generally thought to have the same "fast-spiking" phenotype, which is characterized by a short action potential and high frequency firing without adaptation. However, findings from studies in different species suggest that certain electrophysiological membrane properties might differ between these two cell classes. In this study, we assessed the physiological heterogeneity of fast-spiking interneurons as a function of two factors: species (macaque monkey vs. rat) and morphology (chandelier vs. basket). We showed previously that electrophysiological membrane properties of BCs differ between these two species. Here, for the first time, we report differences in ChCs membrane properties between monkey and rat. We also found that a number of membrane properties differentiate ChCs from BCs. Some of these differences were species-independent (e.g., fast and medium afterhyperpolarization, firing frequency, and depolarizing sag), whereas the differences in the first spike latency between ChCs and BCs were species-specific. Our findings indicate that different combinations of electrophysiological membrane properties distinguish ChCs from BCs in rodents and primates. Such electrophysiological differences between ChCs and BCs likely contribute to their distinctive roles in cortical circuitry in each species. © 2013 Povysheva et al

    Bioinorganic Chemistry of Alzheimer’s Disease

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