Analysis and Synthesis of Metadata Goals for Scientific Data

The proliferation of discipline-specific metadata schemes contributes to artificial barriers that can impede interdisciplinary and transdisciplinary research. The authors considered this problem by examining the domains, objectives, and architectures of nine metadata schemes used to document scientific data in the physical, life, and social sciences. They used a mixed-methods content analysis and Greenberg’s (2005) metadata objectives, principles, domains, and architectural layout (MODAL) framework, and derived 22 metadata-related goals from textual content describing each metadata scheme. Relationships are identified between the domains (e.g., scientific discipline and type of data) and the categories of scheme objectives. For each strong correlation (\u3e0.6), a Fisher’s exact test for nonparametric data was used to determine significance (p \u3c .05). Significant relationships were found between the domains and objectives of the schemes. Schemes describing observational data are more likely to have “scheme harmonization” (compatibility and interoperability with related schemes) as an objective; schemes with the objective “abstraction” (a conceptual model exists separate from the technical implementation) also have the objective “sufficiency” (the scheme defines a minimal amount of information to meet the needs of the community); and schemes with the objective “data publication” do not have the objective “element refinement.” The analysis indicates that many metadata-driven goals expressed by communities are independent of scientific discipline or the type of data, although they are constrained by historical community practices and workflows as well as the technological environment at the time of scheme creation. The analysis reveals 11 fundamental metadata goals for metadata documenting scientific data in support of sharing research data across disciplines and domains. The authors report these results and highlight the need for more metadata-related research, particularly in the context of recent funding agency policy changes

Report and Recommendations Ad Hoc Committee on College Constitutions, September 24, 2013

In a series of email messages in April 2012, the chair of the Faculty Consultative Committee (FCC), Professor Chris Cramer, and Provost Karen Hanson agreed on the appointment of an ad hoc committee on college constitutions. The general charge was to assemble and review the college constitutions, determine their status, identify the important elements that should be included in every constitution, seek an approval process at the central level, and develop an advisory set of minimum procedures or guidelines on what colleges should do to adopt and amend constitutions (e.g., what consultation should take place, who should participate) that the provost could then provide to the colleges. The recommendations should not dictate to the colleges what should be in the constitutions but might suggest best practices for college consideration

A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites

A highly efficacious pre-erythrocytic stage vaccine would be an important tool for the control and elimination of malaria but is currently unavailable. High-level protection in humans can be achieved by experimental immunization with Plasmodium falciparum sporozoites attenuated by radiation or under anti-malarial drug coverage. Immunization with genetically attenuated parasites (GAP) would be an attractive alternative approach. Here we present data on safety and protective efficacy using sporozoites with deletions of two genes i.e. the newly identified b9 and slarp, which govern independent and critical processes for successful liver-stage development. In the rodent malaria model, Pb Delta b9 Delta slarpGAP was completely attenuated showing no breakthrough infections while efficiently inducing high level protection. The human Pf Delta b9 Delta slarpGAP generated without drug-resistance markers were infective to human hepatocytes in vitro and to humanized mice engrafted with human hepatocytes in vivo but completely aborted development after infection. These findings support the clinical development of a Pf Delta b9 Delta slarpSPZ vaccine

Food Groups Associated with a Composite Measure of Probability of Adequate Intake of 11 Micronutrients in the Diets of Women in Urban Mali

The prevalence of micronutrient deficiency is high among women of reproductive age living in urban Mali. Despite this, there are little data on the dietary intake of micronutrients among women of reproductive age in Mali. This research tested the relationship between the quantity of intake of 21 possible food groups and estimated usual micronutrient (folate, vitamin B-12, calcium, riboflavin, niacin, vitamin A, iron, thiamin, vitamin B-6, vitamin C, and zinc) intakes and a composite measure of adequacy of 11 micronutrients [mean probability of adequacy (MPA)] based on the individual probability of adequacy (PA) for the 11 micronutrients. Food group and micronutrient intakes were calculated from 24-h recall data in an urban sample of Malian women. PA was lowest for folate, vitamin B-12, calcium, and riboflavin. The overall MPA for the composite measure of 11 micronutrients was 0.47 +/- 0.18. Grams of intake from the nuts/seeds, milk/yogurt, vitamin A-rich dark green leafy vegetables (DGLV), and vitamin C-rich vegetables food groups were correlated (Spearman's rho = 0.20-0.36; P 0.5, respectively. These findings can be used to further the development of indicators of dietary diversity and to improve micronutrient intakes of women of reproductive age. J. Nutr. 140: 2070S-2078S, 2010

Research on post-harvest technology

Meeting: TAC Meeting, 9th, 3-7 Feb. 1975, Roma, ITMonograph on the need for improved and relevant post-harvest grain processing systems in developing countries. Discusses the need to increase the efficiency of storage, drying, and food processing to promote grain plant production

Informers, Agents and the Liberal Ideology of Collusion in Northern Ireland

There is now considerable evidence of systemic and institutionalised collusion between state forces and loyalists paramilitary groups during the Northern Ireland conflict, not least in the late 1980s and early 1990s. Focusing on a critical reading of the 2012 de Silva report into the killing of human rights lawyer, Pat Finucane, this article examines state collusive practices surrounding the handling of agents and informers as evidence of a culture of collusion extending into the highest echelons of state institutions. The article will argue that such practices evidence an approach to state counterinsurgency predicated on a “doctrine of necessity” and what can be understood as a “liberal ideology of collusion”

Realisation of the metre by using a femtosecond laser frequency comb: applications in optical frequency metrology

The appearance of the frequency comb technology, awarded the Nobel Prize in Physics 2005, has enormously revolutionized the metrology of optical frequencies, eliminating the need for complicated frequency chains. By direct linking to the unit of time, the second, through frequency standards (Cs, Rb), by using femtosecond mode-locked lasers and frequency comb technology, the Spanish Centre of Metrology (CEM) has established a new way of practical realisation of the National Standard of Length, the metre. By stabilising and characterising two free parameters – the repetition frequency fr and the offset frequency f0, the frequency comb generator thereby was successfully put into operation. After such realization, the accuracy of the length unit will be increased in two orders of magnitude, that is 2 × 10−13 instead of 2.1 × 10−11. In this paper we present the results of applying comb generator to the absolute measurement of the three Zeeman stabilized He–Ne lasers operating at 633 nm with a nominal frequency of 473.612 THz. A comparison of these results with those obtained by the current system based on standard iodine stabilized lasers is in good compatibility. A treatment for the evaluation of measurement uncertainty of laser frequency in calibration using a comb in accordance with Guide of Uncertainty Measurement ISO/BIPM is also presented

Biomarkers of Nutrition for Development (BOND)—Iron Review

This is the fifth in the series of reviews developed as part of the Biomarkers of Nutrition for Development (BOND) program. The BOND Iron Expert Panel (I-EP) reviewed the extant knowledge regarding iron biology, public health implications, and the relative usefulness of currently available biomarkers of iron status from deficiency to overload. Approaches to assessing intake, including bioavailability, are also covered. The report also covers technical and laboratory considerations for the use of available biomarkers of iron status, and concludes with a description of research priorities along with a brief discussion of new biomarkers with potential for use across the spectrum of activities related to the study of iron in human health. The I-EP concluded that current iron biomarkers are reliable for accurately assessing many aspects of iron nutrition. However, a clear distinction is made between the relative strengths of biomarkers to assess hematological consequences of iron deficiency versus other putative functional outcomes, particularly the relationship between maternal and fetal iron status during pregnancy, birth outcomes, and infant cognitive, motor and emotional development. The I-EP also highlighted the importance of considering the confounding effects of inflammation and infection on the interpretation of iron biomarker results, as well as the impact of life stage. Finally, alternative approaches to the evaluation of the risk for nutritional iron overload at the population level are presented, because the currently designated upper limits for the biomarker generally employed (serum ferritin) may not differentiate between true iron overload and the effects of subclinical inflammation