Effect of New Zealand Blackcurrant Extract on Repeated Cycling Time Trial Performance

Abstract: New Zealand blackcurrant (NZBC) extract increased 16.1 km cycling time trial performance. The aim of the present study was to examine the effect of NZBC extract on 2 × 4 km time trial performance. Ten male cyclists (age: 30 ± 12 years, body mass: 74 ± 9 kg, height: 179 ± 7 cm, body fat: 11 ± 3%, V˙ O2max: 55 ± 7 mL·kg−1·min−1, mean ± SD) volunteered. Participants were familiarized with the time trials. Participants consumed capsulated NZBC extract (300 mg·day−1 CurraNZ™; containing 105 mg anthocyanin) or placebo for seven days (double blind, randomised, cross-over design, wash-out at least seven days) before 2 × 4 km time trials (10 min active self-paced recovery between trials) (SRM ergometer, SRM International, Germany). Heart rate was recorded and blood lactate sampled immediately after each trial and 8 min into recovery between the trials. Times over comparable one km distances in each 4 km time trial were similar. No effect was observed for the time to complete the first (placebo: 380 ± 28 s, NZBC: 377 ± 27 s) and second 4 km of cycling (placebo: 391 ± 32 s, NZBC: 387 ± 30 s), within both groups the second 4 km times slower by 11 ± 8 s and 11 ± 9 s for placebo and NZBC, respectively. However, the total time of the two 4 km cycling trials was 0.82% faster with NZBC extract (placebo: 771 ± 60 s, NZBC 764 ± 56 s, p = 0.034) with seven participants having faster total times. There was no effect of NZBC on heart rate and lactate values at identical time points. New Zealand blackcurrant extract seems to be beneficial in repeated short-distance cycling time trials for overall performance

Diamond like carbon coatings for potential application in biological implants – a review

Production of wear debris has been linked to the failure of numerous hip implants. With the current focus on increasing the implant longevity, thus wear and corrosion resistance is important. Hard coatings have the potential to reduce the wear and corrosion. Diamond like Carbon (DLC) coatings exhibit properties that could make them viable for implants. This paper critically reviews previously published research into usage of DLC coatings for implants. Overall DLCs seem to be an effective coating for implants but with the variance in results, further testing is required for clarification of us

Phase transitions and noise crosscorrelations in a model of directed polymers in a disordered medium

We show that effective interactions mediated by disorder between two directed polymers can be modelled as the crosscorrelation of noises in the Kardar-Parisi-Zhang (KPZ) equations satisfied by the respective free energies of these polymers. When there are two polymers, disorder introduces attractive interactions between them. We analyze the phase diagram in details and show that these interactions lead to new phases in the phase diagram. We show that, even in dimension $d=1$, the two directed polymers see the attraction only if the strength of the disorder potential exceeds a threshold value. We extend our calculations to show that if there are $m$ polymers in the system then $m$-body interactions are generated in the disorder averaged effective free energy.Comment: To appear in Phys. Rev. E(2000

Disease-specific, neurosphere-derived cells as models for brain disorders

There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses. We describe here a new cell model based on patient-derived cells from the human olfactory mucosa, the organ of smell, which regenerates throughout life from neural stem cells. Olfactory mucosa biopsies were obtained from healthy controls and patients with either schizophrenia, a neurodevelopmental psychiatric disorder, or Parkinson's disease, a neurodegenerative disease. Biopsies were dissociated and grown as neurospheres in defined medium. Neurosphere-derived cell lines were grown in serum-containing medium as adherent monolayers and stored frozen. By comparing 42 patient and control cell lines we demonstrated significant disease-specific alterations in gene expression, protein expression and cell function, including dysregulated neurodevelopmental pathways in schizophrenia and dysregulated mitochondrial function, oxidative stress and xenobiotic metabolism in Parkinson's disease. The study has identified new candidate genes and cell pathways for future investigation. Fibroblasts from schizophrenia patients did not show these differences. Olfactory neurosphere-derived cells have many advantages over embryonic stem cells and induced pluripotent stem cells as models for brain diseases. They do not require genetic reprogramming and they can be obtained from adults with complex genetic diseases. They will be useful for understanding disease aetiology, for diagnostics and for drug discovery

Carbon Capture and Storage

Emissions of carbon dioxide, the most important long-lived anthropogenic greenhouse gas, can be reduced by Carbon Capture and Storage (CCS). CCS involves the integration of four elements: CO 2 capture, compression of the CO2 from a gas to a liquid or a denser gas, transportation of pressurized CO 2 from the point of capture to the storage location, and isolation from the atmosphere by storage in deep underground rock formations. Considering full life-cycle emissions, CCS technology can reduce 65–85% of CO2 emissions from fossil fuel combustion from stationary sources, although greater reductions may be possible if low emission technologies are applied to activities beyond the plant boundary, such as fuel transportation. CCS is applicable to many stationary CO2 sources, including the power generation, refining, building materials, and the industrial sector. The recent emphasis on the use of CCS primarily to reduce emissions from coal-fired electricity production is too narrow a vision for CCS. Interest in CCS is growing rapidly around the world. Over the past decade there has been a remarkable increase in interest and investment in CCS. Whereas a decade ago, there was only one operating CCS project and little industry or government investment in R&D, and no financial incentives to promote CCS. In 2010, numerous projects of various sizes are active, including at least five large-scale full CCS projects. In 2015, it is expected that 15 large-scale, full-chain CCS projects will be running. Governments and industry have committed over USD 26 billion for R&D, scale-up and deployment. The technology for CCS is available today, but significant improvements are needed to support widespread deployment. Technology advances are needed primarily to reduce the cost of capture and increase confidence in storage security. Demonstration projects are needed to address issues of process integration between CO2 capture and product generation, for instance in power, cement and steel production, obtain cost and performance data, and for industry where capture is more mature to gain needed operational experience. Large-scale storage projects in saline aquifers are needed to address issues of site characterization and site selection, capacity assessment, risk management and monitoring. Successful experiences from five ongoing projects demonstrate that, at least on this limited scale, CCS can be safe and effective for reducing emissions. Five commercial-scale CCS projects are operational today with over 35 million tonnes of CO2 captured and stored since 1996. Observations from commercial storage projects, commercial enhanced oil recovery projects, engineered and natural analogues as well as theoretical considerations, models, and laboratory experiments suggest that appropriately selected and managed geological storage reservoirs are very likely to retain nearly all the injected CO2 for very long times, more than long enough to provide benefits for the intended purpose of CCS. Significant scale-up compared to existing CCS activities will be needed to achieve large reductions in CO2 emissions. A 5- to 10-fold scale-up in the size of individual projects is needed to capture and store emissions from a typical coal-fired power plant (500 to 1000 MW). A thousand fold scale-up in size of today’s CCS enterprise would be needed to reduce emissions by billions of tonnes per year (Gt/yr). The technical potential of CCS on a global level is promising, but on a regional level is differentiated. The primary technical limitation for CCS is storage capacity. Much more work needs to be done to realistically assess storage capacity on a worldwide, regional basis and sub-regional basis. Worldwide storage capacity estimation is improving but more experience is needed. Estimates for oil and gas reservoirs are about 1000 GtCO2, saline aquifers are estimated to have a capacity ranging from about 4000 to 23,000 GtCO2. However, there is still considerable debate about how much storage capacity actually exists, particularly in saline aquifers. Research, geological assessments and, most importantly, commercial-scale demonstration projects will be needed to improve confidence in capacity estimates. Costs and energy requirements for capture are high. Estimated costs for CCS vary widely, depending on the application (e.g. gas clean-up vs. electricity generation), the type of fuel, capture technology, and assumptions about the baseline technology. For example, with today’s technology, CCS would increase cost of generating electricity by 50–100%. In this case, capital costs and parasitic energy requirements of 15–30% are the major cost drivers. Research is underway to lower costs and energy requirements. Early demonstration projects are likely to cost more. The combination of high cost and low or absent incentives for large-scale deployment are a major factor limiting the widespread use of CCS. Due to high costs, CCS will not take place without strong incentives to limit CO2 emissions. Certainty about the policy and regulatory regimes will be crucial for obtaining access to capital to build these multi-billion dollar projects. Environmental risks of CCS appear manageable, but regulations are needed. Regulation needs to ensure due diligence over the lifecycle of the project, but should, most importantly, also govern site selection, operating guidelines, monitoring and closure of a storage facility. Experience so far has shown that local resistance to CO2 storage projects may appear and can lead to cancellation of planned CCS projects. Inhabitants of the areas around geological storage sites often have concerns about the safety and effectiveness of CCS. More CCS projects are needed to establish a convincing safety record. Early engagement of communities in project design and site selection as well as credible communication can help ease resistance. Environmental organisations sometimes see CCS as a distraction from a sustainable energy future. Social, economic, policy and political factors may limit deployment of CCS if not adequately addressed. Critical issues include ownership of underground pore space (primarily an issue in the US); long-term liability and stewardship; GHG accounting approaches and ve rification; and regulatory oversight regimes. Governments and the private sector are making significant progress on all of these issues. Government support to lower barriers for early deployments is needed to encourage private sector adoption. Developing countries will need support for technology access, lowering the cost of CCS, developing workforce capacity and training regulators for permitting, monitoring and oversight. CCS combined with biomass can lead to negative emissions . Such technologies are likely to be needed to achieve atmospheric stabilization of CO2 and may provide an additional incentive for CCS adoption

Stress corrosion cracking in Al-Zn-Mg-Cu aluminum alloys in saline environments

Copyright 2013 ASM International. This paper was published in Metallurgical and Materials Transactions A, 44A(3), 1230 - 1253, and is made available as an electronic reprint with the permission of ASM International. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplications of any material in this paper for a fee or for commercial purposes, or modification of the content of this paper are prohibited.Stress corrosion cracking of Al-Zn-Mg-Cu (AA7xxx) aluminum alloys exposed to saline environments at temperatures ranging from 293 K to 353 K (20 °C to 80 °C) has been reviewed with particular attention to the influences of alloy composition and temper, and bulk and local environmental conditions. Stress corrosion crack (SCC) growth rates at room temperature for peak- and over-aged tempers in saline environments are minimized for Al-Zn-Mg-Cu alloys containing less than ~8 wt pct Zn when Zn/Mg ratios are ranging from 2 to 3, excess magnesium levels are less than 1 wt pct, and copper content is either less than ~0.2 wt pct or ranging from 1.3 to 2 wt pct. A minimum chloride ion concentration of ~0.01 M is required for crack growth rates to exceed those in distilled water, which insures that the local solution pH in crack-tip regions can be maintained at less than 4. Crack growth rates in saline solution without other additions gradually increase with bulk chloride ion concentrations up to around 0.6 M NaCl, whereas in solutions with sufficiently low dichromate (or chromate), inhibitor additions are insensitive to the bulk chloride concentration and are typically at least double those observed without the additions. DCB specimens, fatigue pre-cracked in air before immersion in a saline environment, show an initial period with no detectible crack growth, followed by crack growth at the distilled water rate, and then transition to a higher crack growth rate typical of region 2 crack growth in the saline environment. Time spent in each stage depends on the type of pre-crack (“pop-in” vs fatigue), applied stress intensity factor, alloy chemistry, bulk environment, and, if applied, the external polarization. Apparent activation energies (E a) for SCC growth in Al-Zn-Mg-Cu alloys exposed to 0.6 M NaCl over the temperatures ranging from 293 K to 353 K (20 °C to 80 °C) for under-, peak-, and over-aged low-copper-containing alloys (~0.8 wt pct), they are typically ranging from 20 to 40 kJ/mol for under- and peak-aged alloys, and based on limited data, around 85 kJ/mol for over-aged tempers. This means that crack propagation in saline environments is most likely to occur by a hydrogen-related process for low-copper-containing Al-Zn-Mg-Cu alloys in under-, peak- and over-aged tempers, and for high-copper alloys in under- and peak-aged tempers. For over-aged high-copper-containing alloys, cracking is most probably under anodic dissolution control. Future stress corrosion studies should focus on understanding the factors that control crack initiation, and insuring that the next generation of higher performance Al-Zn-Mg-Cu alloys has similar longer crack initiation times and crack propagation rates to those of the incumbent alloys in an over-aged condition where crack rates are less than 1 mm/month at a high stress intensity factor

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system.

Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection. One of the principal factors that control the outcome of infection is the localized tissue response and subsequent immune response directed against the invading toxic agent. It is the role of the immune system to contain and control the spread of virus infection in the central nervous system (CNS), and paradoxically, this response may also be pathologic. Chemokines are potent proinflammatory molecules whose expression within virally infected tissues is often associated with protection and/or pathology which correlates with migration and accumulation of immune cells. Indeed, studies with a neurotropic murine coronavirus, mouse hepatitis virus (MHV), have provided important insight into the functional roles of chemokines and chemokine receptors in participating in various aspects of host defense as well as disease development within the CNS. This chapter will highlight recent discoveries that have provided insight into the diverse biologic roles of chemokines and their receptors in coordinating immune responses following viral infection of the CNS

Detector Description and Performance for the First Coincidence Observations between LIGO and GEO

For 17 days in August and September 2002, the LIGO and GEO interferometer gravitational wave detectors were operated in coincidence to produce their first data for scientific analysis. Although the detectors were still far from their design sensitivity levels, the data can be used to place better upper limits on the flux of gravitational waves incident on the earth than previous direct measurements. This paper describes the instruments and the data in some detail, as a companion to analysis papers based on the first data.Comment: 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial change

Production of Medical Radioisotopes with High Specific Activity in Photonuclear Reactions with γ\gamma Beams of High Intensity and Large Brilliance

We study the production of radioisotopes for nuclear medicine in $(\gamma,x{\rm n}+y{\rm p})$ photonuclear reactions or ($\gamma,\gamma'$) photoexcitation reactions with high flux [($10^{13}-10^{15}$)$\gamma$/s], small diameter $\sim (100 \, \mu$m$)^2$ and small band width ($\Delta E/E \approx 10^{-3}-10^{-4}$) $\gamma$ beams produced by Compton back-scattering of laser light from relativistic brilliant electron beams. We compare them to (ion,$x$n$+ y$p) reactions with (ion=p,d,$\alpha$) from particle accelerators like cyclotrons and (n,$\gamma$) or (n,f) reactions from nuclear reactors. For photonuclear reactions with a narrow $\gamma$ beam the energy deposition in the target can be managed by using a stack of thin target foils or wires, hence avoiding direct stopping of the Compton and pair electrons (positrons). $(\gamma,\gamma')$ isomer production via specially selected $\gamma$ cascades allows to produce high specific activity in multiple excitations, where no back-pumping of the isomer to the ground state occurs. We discuss in detail many specific radioisotopes for diagnostics and therapy applications. Photonuclear reactions with $\gamma$ beams allow to produce certain radioisotopes, e.g. $^{47}$Sc, $^{44}$Ti, $^{67}$Cu, $^{103}$Pd, $^{117m}$Sn, $^{169}$Er, $^{195m}$Pt or $^{225}$Ac, with higher specific activity and/or more economically than with classical methods. This will open the way for completely new clinical applications of radioisotopes. For example $^{195m}$Pt could be used to verify the patient's response to chemotherapy with platinum compounds before a complete treatment is performed. Also innovative isotopes like $^{47}$Sc, $^{67}$Cu and $^{225}$Ac could be produced for the first time in sufficient quantities for large-scale application in targeted radionuclide therapy.Comment: submitted to Appl. Phys.

Search for Gravitational Waves from Primordial Black Hole Binary Coalescences in the Galactic Halo

We use data from the second science run of the LIGO gravitational-wave detectors to search for the gravitational waves from primordial black hole (PBH) binary coalescence with component masses in the range 0.2--$1.0 M_\odot$. The analysis requires a signal to be found in the data from both LIGO observatories, according to a set of coincidence criteria. No inspiral signals were found. Assuming a spherical halo with core radius 5 kpc extending to 50 kpc containing non-spinning black holes with masses in the range 0.2--$1.0 M_\odot$, we place an observational upper limit on the rate of PBH coalescence of 63 per year per Milky Way halo (MWH) with 90% confidence.Comment: 7 pages, 4 figures, to be submitted to Phys. Rev.