Igneous differentiation in porphyry dikes

[Resumen] Se aborda de manera teórica los principales procesos operativos de diferenciación ígnea en secciones transversales de los conductos filonianos, aplicándolo a los diques de pórfido granítico s. 1. del Sistema Central Español. Para estos magmas se deduce un régimen de flujo marcadamente laminar en el conducto (:~ 30 mts. potencia). Estos caracteres impiden tanto la efectividad de franccionamiento cristalino «in situ:\), como grados importantes de asimilación o contaminación en ruta hacia la superficie. Los diques simples, de flujos isoviscosos, van a diferenciarse por fenómenos, principalmente, de flujo ígneo, en ocasiones combinado con la presencia de varios magmas fluyendo a la vez en el mismo pulso (conductos gruesos o flujos veloces). Con estos mecanismos se tenderá a generar evoluciones del tipo félsico a máfico, de borde a centro del dique de pórfido. Los diques compuestos se formarán cuando los magmas son suficientemente contrastados en sus caracteres físicos (viscosidad, p. ej.) y químicos, o cuando son varíos pulsos magmáticos a través del mismo conducto. En estos casos podría haber fen6menos de mezcla magmática si la diferencia de viscosidad es alta y uno de esos magmas es poco viscoso (magmas básicos). En estos casos podrían generarse zonas básicas en el borde, o no, de los diques. de pórfido. En resumen la diferenciación de flujo, la mezcla magmática y la asociación de varios líquidos fluyendo en el mismo conducto (de manera simultánea o por pulsos magmáticos algo separados en el tiempo), parecen ser los mecanismos de diferenciación ígnea más efectivos de estos magmas graníticos que fluyen en angostos conductos filonianos[Abstract] We deal in theoretical way wíth the main differentiation proccesses taking place in dike conducts, applied to the porphyry dikes of the Spanish Central System. For these magmas we infer a strong laminar flow regime (~30 m dike witdh). This, prevent an efficient «in situ:\) cristal fractionation as well as large extent of assimilation-contamination processes during the ascent of the magmas «en route» to more surface levels. Simple dikes, with isoviscous flow, could differentiate mainley by igneous flow. Sometimes this mechanism is combinated with the possibility of severa! Magmas flowing togheter on the same pulse (thick dikes or fast flows). With these mechanisms felsic to mafic evolutions are favoured inward the porphyry dike. Composite dikes are formed when magmas are contrasted enough in their chemical or physical features (p. ej. viscosity), or when different magmatic pulses occur in the same channel. In these conditions commingling of magmas could exist if the viscosity ratio is high apd one of the magmas is very fluid (basic one). These processes could generate basic margins in the porphyry dikes. In short, flow differentiation, magmatic mixing and flowing of associated magmas (simultaneously or by successive pulses), seem to be the more efficient differentiation mechanisms for granitic magmas flowing in narrow dikes

“PRESCRIPCIÓN DE METFORMINA EN PACIENTES ANCIANOS HOSPITALIZADOS CON CONTRAINDICACIÓN PARA LA MISMA, EN EL CENTRO MEDICO ISSEMyM DE ENERO DEL AÑO 2009 A ENERO DEL 2012”

El uso de metformina ha sido asociado con el desarrollo de acidosis láctica, la cual aumenta su incidencia ante la presencia de ciertos factores de riesgo, éstos son considerados como contraindicados para el uso de la metformina, sin embargo se ha descrito la prescripción inadecuada de la metformina frecuentemente en pacientes que tienen alguna de éstas contraindicaciones. Aunque la incidencia de ésta complicación es baja, tiene una alta tasa de mortalidad, por lo que al prescribir metformina debera individualizarse en cada paciente según las guías de recomendaciones y precauciones de este hipoglucemiante oral, sin embargo la presencia de múltiples comorbilidades en los ancianos como lo son Enfermedad pulmonar obstructiva Crónica, Insuficiencia Renal Crónica, Insuficiencia Cardiaca Congestiva, Insuficiencia arterial lo qué hace que el tratamiento farmacológico con hipoglucemiantes orales requiera la consideración de interacciones fármaco-enfermedad y fármaco-fármaco. Se han reportado hasta mayor a un 20% la prescripción inadecuada de metformina en este grupo de pacientes

Task demands modulate decision and eye movement responses in the chimeric face test: examining the right hemisphere processing account

A large and growing body of work, conducted in both brain-intact and brain-damaged populations, has used the free viewing chimeric face test as a measure of hemispheric dominance for the extraction of emotional information from faces. These studies generally show that normal right-handed individuals tend to perceive chimeric faces as more emotional if the emotional expression is presented on the half of the face to the viewer's left (“left hemiface”). However, the mechanisms underlying this lateralized bias remain unclear. Here, we examine the extent to which this bias is driven by right hemisphere processing advantages vs. default scanning biases in a unique way—by changing task demands. In particular, we compare the original task with one in which right-hemisphere-biased processing cannot provide a decision advantage. Our behavioral and eye movement data are inconsistent with the predictions of a default scanning bias account and support the idea that the left hemiface bias found in the chimeric face test is largely due to strategic use of right hemisphere processing mechanisms

Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa

Objective To evaluate the performance of diagnostic tools for diabetes mellitus, including laboratory methods and clinical risk scores, in newly-diagnosed pulmonary tuberculosis patients from four middle-income countries. Methods In a multicentre, prospective study, we recruited 2185 patients with pulmonary tuberculosis from sites in Indonesia, Peru, Romania and South Africa from January 2014 to September 2016. Using laboratory-measured glycated haemoglobin (HbA1c) as the gold standard, we measured the diagnostic accuracy of random plasma glucose, point-of-care HbA1c, fasting blood glucose, urine dipstick, published and newly derived diabetes mellitus risk scores and anthropometric measurements. We also analysed combinations of tests, including a two-step test using point-of-care HbA1cwhen initial random plasma glucose was ≥ 6.1 mmol/L. Findings The overall crude prevalence of diabetes mellitus among newly diagnosed tuberculosis patients was 283/2185 (13.0%; 95% confidence interval, CI: 11.6–14.4). The marker with the best diagnostic accuracy was point-of-care HbA1c (area under receiver operating characteristic curve: 0.81; 95% CI: 0.75–0.86). A risk score derived using age, point-of-care HbA1c and random plasma glucose had the best overall diagnostic accuracy (area under curve: 0.85; 95% CI: 0.81–0.90). There was substantial heterogeneity between sites for all markers, but the two-step combination test performed well in Indonesia and Peru. Conclusion Random plasma glucose followed by point-of-care HbA1c testing can accurately diagnose diabetes in tuberculosis patients, particularly those with substantial hyperglycaemia, while reducing the need for more expensive point-of-care HbA1c testing. Risk scores with or without biochemical data may be useful but require validation

Variable order Mittag-Leffler fractional operators on isolated time scales and application to the calculus of variations

We introduce new fractional operators of variable order on isolated time scales with Mittag-Leffler kernels. This allows a general formulation of a class of fractional variational problems involving variable-order difference operators. Main results give fractional integration by parts formulas and necessary optimality conditions of Euler-Lagrange type.Comment: This is a preprint of a paper whose final and definite form is with Springe

Evidence of suppression of onchocerciasis transmission in the Venezuelan Amazonian focus.

BACKGROUND: The World Health Organization (WHO) has set goals for onchocerciasis elimination in Latin America by 2015. Most of the six previously endemic countries are attaining this goal by implementing twice a year (and in some foci, quarterly) mass ivermectin (Mectizan®) distribution. Elimination of transmission has been verified in Colombia, Ecuador and Mexico. Challenges remain in the Amazonian focus straddling Venezuela and Brazil, where the disease affects the hard-to-reach Yanomami indigenous population. We provide evidence of suppression of Onchocerca volvulus transmission by Simulium guianense s.l. in 16 previously hyperendemic Yanomami communities in southern Venezuela after 15 years of 6-monthly and 5 years of 3-monthly mass ivermectin treatment. METHODS: Baseline and monitoring and evaluation parasitological, ophthalmological, entomological and serological surveys were conducted in selected sentinel and extra-sentinel communities of the focus throughout the implementation of the programme. RESULTS: From 2010 to 2012–2015, clinico-parasitological surveys indicate a substantial decrease in skin microfilarial prevalence and intensity of infection; accompanied by no evidence (or very low prevalence and intensity) of ocular microfilariae in the examined population. Of a total of 51,341 S. guianense flies tested by PCR none had L3 infection (heads only). Prevalence of infective flies and seasonal transmission potentials in 2012–2013 were, respectively, under 1 % and 20 L3/person/transmission season. Serology in children aged 1–10 years demonstrated that although 26 out of 396 (7 %) individuals still had Ov-16 antibodies, only 4/218 (2 %) seropositives were aged 1–5 years. CONCLUSIONS: We report evidence of recent transmission and morbidity suppression in some communities of the focus representing 75 % of the Yanomami population and 70 % of all known communities. We conclude that onchocerciasis transmission could be feasibly interrupted in the Venezuelan Amazonian focus. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-016-1313-z) contains supplementary material, which is available to authorized users

Rationing tests for drug-resistant tuberculosis - who are we prepared to miss?

BACKGROUND: Early identification of patients with drug-resistant tuberculosis (DR-TB) increases the likelihood of treatment success and interrupts transmission. Resource-constrained settings use risk profiling to ration the use of drug susceptibility testing (DST). Nevertheless, no studies have yet quantified how many patients with DR-TB this strategy will miss. METHODS: A total of 1,545 subjects, who presented to Lima health centres with possible TB symptoms, completed a clinic-epidemiological questionnaire and provided sputum samples for TB culture and DST. The proportion of drug resistance in this population was calculated and the data was analysed to demonstrate the effect of rationing tests to patients with multidrug-resistant TB (MDR-TB) risk factors on the number of tests needed and corresponding proportion of missed patients with DR-TB. RESULTS: Overall, 147/1,545 (9.5%) subjects had culture-positive TB, of which 32 (21.8%) had DR-TB (MDR, 13.6%; isoniazid mono-resistant, 7.5%; rifampicin mono-resistant, 0.7%). A total of 553 subjects (35.8%) reported one or more MDR-TB risk factors; of these, 506 (91.5%; 95% CI, 88.9-93.7%) did not have TB, 32/553 (5.8%; 95% CI, 3.4-8.1%) had drug-susceptible TB, and only 15/553 (2.7%; 95% CI, 1.5-4.4%) had DR-TB. Rationing DST to those with an MDR-TB risk factor would have missed more than half of the DR-TB population (17/32, 53.2%; 95% CI, 34.7-70.9). CONCLUSIONS: Rationing DST based on known MDR-TB risk factors misses an unacceptable proportion of patients with drug-resistance in settings with ongoing DR-TB transmission. Investment in diagnostic services to allow universal DST for people with presumptive TB should be a high priority

Neorealism and the Organization of American States (OAS): an examination of CARICOM rationality toward Venezuela and the United States

Since 2017, CARICOM member states have been divided in the positions they take on Organization of American States (OAS) resolutions addressing political instability in Venezuela. This article uses a neorealism framework to determine whether or not the provision of energy investments by Venezuela and the United States to CARICOM member countries is an attempt on their part to skew the OAS voting mechanism in their national interests. The article also examines the extent to which CARICOM member states’ response to Venezuela’s and United States’ interest in the OAS demonstrates a pattern of rationality. The findings suggest that though the OAS provides a medium for states to negotiate mutually beneficial solutions, states are rational actors and even where they do corporate, dominant states may try to manifest their self-interest