The public debt management and the political marketing in the context of negative economic fluctuations on a global level

The economic crisis which affects a globally states economy is capable to change the economic system based on continued economic growth. Thus, the economic shocks which take place in the economy, could affect the activities of individuals in different periods of time. The mix of economic measures must create a healthy economic development. The institutional regulation represents a fundamental element to prevent the economic crises. The article aims to present the influences that have caused the economic crisis on the political marketing strategy and the public debt management. The cyclicality of the global economy reveals that the economy is adjusted by economic crisis that take place at different time intervals. The prevention of major economic slippages represents a way of guidance policies which having been performed at the state level. Creating a solid financial and economic system, based on the supply and demand freedom must lead to a stable economic environment, which is favorable to economic growth

Chemical Composition, Antioxidant and Antiproliferative Activities of Taraxacum officinale Essential Oil

Taraxacum officinale (TO) has been historically used for medicinal purposes due to its biological activity against specific disorders. To investigate the antioxidant and the antiproliferativepotential of TO essential oil in vitro and in vivo, the chemical composition of the essential oil was analyzed by GC-MS. The in vivo antioxidant capacity was assessed on liver and kidney homogenate samples from mice subjected to acetaminophen-induced oxidative stress and treated with TO essential oil (600 and 12,000 mg/kg BW) for 14 days. The in vitro scavenging activity was assayed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the reducing power methods. The cytotoxic effects against the HeLa cancer cell line were analyzed. The GC-MS analysis showed the presence of 34 compounds, 8 of which were identified as major constituents. The TO essential oil protected mice’s liver and kidneys from acetaminophen-induced oxidative stress by enhancing antioxidant enzymes (catalase, superoxide dismutase, and glutathione) and lowering malondialdehyde levels. In vitro, the TO essential oil demonstrated low scavenging activity against DPPH (IC50 = 2.00 ± 0.05 mg/mL) and modest reducing power (EC50 = 0.963 ± 0.006 mg/mL). The growth of the HeLa cells was also reduced by the TO essential oil with an inhibition rate of 83.58% at 95 µg/mL. Current results reveal significant antioxidant and antiproliferative effects in a dose-dependent manner and suggest that Taraxacum officinale essential oil could be useful in formulations for cancer therapy