The Life and Miracles of Fisher Alumnus…

In lieu of an abstract, below is the essay\u27s first paragraph. Before arriving to St. John Fisher College, I was your typical teenage student. I worked hard in school, enjoyed spending time with my friends, and was very close to my family. Granted, I did try to differentiate myself from the rest by joining various clubs such as Peer Ministry and the literary magazine; however, these activities were just the norm and my role was often minor. It would not be until my arrival at St. John Fisher College that my journey of growth would begin

An Empirical Analysis on Board Monitoring Role and Loan Portfolio Quality Measurement in Banks

This paper aims to analyze the effectiveness of the board monitoring role on specific loan portfolio quality measures in banks (default rate, recovery rate and provisioning rate). We use a sample comprises a totality of Italian-based banks, listed at Borsa Italiana SpA in 2006-2008 and a number of accounting proxies to express the loan portfolio quality of a bank. The results of the analysis show an overall weakness of the board role (expressed by Independents and Audit Committee on board) in monitoring loan portfolio quality of the bank, with the subsequent damage of the interests of stakeholders. A positive contribution of board monitoring, even if partial, is highlighted in two cases: Independents seems improve recovery rate, while the Audit committee enhances provisioning rate in banks. With reference to default rate, a total negative effect of board monitoring is reported. On the base of these results, some managerial implications are proposed.Banks, Corporate governance, Board of directors, Loan Portfolio Quality

Escape in the Wilderness

In lieu of an abstract, below is the essay\u27s first paragraph. Out on her deck overlooking the wilderness, the mother was looking for her son. Her 13-year-old ran away again. She figured he was somewhere out in the back of their five acres, but she had no idea where. She clutched her whiskey glass and lit a cigarette. She screamed his name in a voice that sounded like she had a sore throat. She listened for a response as she finished her drink. In her Mrs. cleaver house dress and white ruffled apron, she thought to herself, boy is he going to get it

Il circolo di Cambridge: dantismo e follia

The ten circles of Dante’s Inferno, with the words that clash in eternity, are the background to the thriller of the Spanish writer who draws copiously from the medieval source and dialogues with Dante through the mad mind of his protagonist who, within a perverse play of mirrors, the poet is identified and assumes the function of guiding the world that ill-lives

Un giallo italiano all’origine della ripresa del culto dantesco

In the essay, the author conducts an intertextual inquiry that highlights the terms of the ‘dialogue’ between ancient and modern, in which Dante’s Comedy invariably returns a source the source, always alive and current, to which Giulio Leoni draws copiously for the writing of the novel I crimes of the Medusa, first effort of ‘his’ Dante cycle, and important ‘apripista’ for the revival of the reuse of Dante in contemporary genre fiction.Nel saggio l’autrice conduce un’indagine intertestuale che evidenzia i termini del ‘dialogo’ tra antico e moderno, in cui la Commedia dantesca ritorna prepotentemente a costituire la fonte, sempre viva e attuale, a cui Giulio Leoni attinge copiosamente per la stesura del romanzo I delitti della Medusa, prima fatica del ‘suo’ ciclo dantesco, e importante ‘apripista’ per il rilancio del riuso dantesco nella narrativa contemporanea di genere

Charmed Baryonium

We re-analyze the published data on the Y(4630) --> Lambda_c Lambdabar_c and the Y(4660) --> psi(2S) pi pi with a consistent Ansatz and we find that the two observations are likely to be due to the same state Y_B with M_{Y_B} = 4660.7 +- 8.7 MeV and Gamma_{Y_B} = 61 +- 23 MeV. Under this hypothesis and reanalizing also the e+e- --> J/psi pi pi gamma_ISR spectrum we extract B(Y_B --> Lambda_c Lambdabar_c) / B(Y_B --> psi(2S) pi pi) = 25 +- 7, B(Y_B --> J/psi pi pi) / B(Y_B --> psi(2S) pi pi) J/psi pi pi) / B(Y(4350) --> psi(2S) pi pi) psi(2S) sigma) / B (Y_B --> psi(2S) f_0)=2.0 +- 0.3. These conclusions strongly support the hypothesis of Y_B being the first observation of a charmed baryonium constituted by four quarks. From the analysis of the mass spectrum and the decay properties we show that Y(4350) and Y_B are respectively consistent with the ground state and first radial excitation of the L=1 state.Comment: Corrected phase space normalization in the fit

EFFECTS OF NDL-PCB ON PORCINE MACROPHAGES: PRELIMINARY RESULTS

Polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) causing adverse effects on both humans and animals. Immune system is an important target organ for many environmental contaminants. Macrophages constitute an important component of the immune system of humans and animals, in fact, they are responsible for triggering innate immune responses and host defense. The aim of the current study was to assess the immunomodulatory effects of certain non dioxin like PCBs (PCB 138; PCB 153 and PCB 180) using porcine macrophage 3D4/31 cell line. We evaluated not only the effects induced by the individual congeners but also those deriving from mixtures of more contaminants, in consideration of the fact that co-contamination of the same substrate is common in natural conditions and the effects of simultaneous exposure to multiple contaminants are still little investigated. The results of the current study showed that ndl-PCBs reduced significantly cell viability only at the highest concentration (50 µM); such effect was not linked to apoptosis induction or cell cycle arrest. The contemporary presence of more than one contaminant (differently combined) did not induce any enhancement of effects on 3D4/31 cell line

C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro

Subjects carrying the T2238C ANP gene variant have a higher risk to suffer a stroke or myocardial infarction. The mechanisms through which T2238C/αANP exerts detrimental vascular effects need to be fully clarified. In the present work we aimed at exploring the impact of C2238/αANP (mutant form) on atherosclerosis-related pathways. As a first step, an atherosclerosis gene expression macroarray analysis was performed in vascular smooth muscle cells (VSMCs) exposed to either T2238/αANP (wild type) or C2238/αANP. The major finding was that apolipoprotein E (ApoE) gene expression was significantly downregulated by C2238/αANP and it was upregulated by T2238/αANP. We subsequently found that C2238/αANP induces ApoE downregulation through type C natriuretic peptide receptor (NPR-C)-dependent mechanisms involving the upregulation of miR199a-3p and miR199a-5p and the downregulation of DNAJA4. In fact, NPR-C knockdown rescued ApoE level. Upregulation of miR199a by NPR-C was mediated by a reactive oxygen species-dependent increase of the early growth response protein-1 (Egr-1) transcription factor. In fact, Egr-1 knockdown abolished the impact of C2238/αANP on ApoE and miR199a. Of note, downregulation of ApoE by C2238/αANP was associated with a significant increase in inflammation, apoptosis and necrosis that was completely rescued by the exogenous administration of recombinant ApoE. In conclusion, our study dissected a novel mechanism of vascular damage exerted by C2238/αANP that is mediated by ApoE downregulation. We provide the first demonstration that C2238/αANP downregulates ApoE in VSMCs through NPR-C-dependent activation of Egr-1 and the consequent upregulation of miR199a. Restoring ApoE levels could represent a potential therapeutic strategy to counteract the harmful effects of C2238/αANP

Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat

UCP2 maps nearby the lod score peak of STR1-stroke QTL in the SHRSP rat strain. We explored the potential contribution of UCP2 to the high-salt diet (JD)-dependent increased stroke susceptibility of SHRSP. Male SHRSP, SHRSR, two reciprocal SHRSR/SHRSP-STR1/QTL stroke congenic lines received JD for 4 weeks to detect brain UCP2 gene/protein modulation as compared with regular diet (RD). Brains were also analyzed for NF-κB protein expression, oxidative stress level and UCP2-targeted microRNAs expression level. Next, based on knowledge that fenofibrate and Brassica Oleracea (BO) stimulate UCP2 expression through PPARα activation, we monitored stroke occurrence in SHRSP receiving JD plus fenofibrate versus vehicle, JD plus BO juice versus BO juice plus PPARα inhibitor. Brain UCP2 expression was markedly reduced by JD in SHRSP and in the (SHRsr.SHRsp-(D1Rat134-Mt1pa)) congenic line, whereas NF-κB expression and oxidative stress level increased. The opposite phenomenon was observed in the SHRSR and in the (SHRsp.SHRsr-(D1Rat134-Mt1pa)) reciprocal congenic line. Interestingly, the UCP2-targeted rno-microRNA-503 was significantly upregulated in SHRSP and decreased in SHRSR upon JD, with consistent changes in the two reciprocal congenic lines. Both fenofibrate and BO significantly decreased brain microRNA-503 level, upregulated UCP2 expression and protected SHRSP from stroke occurrence. In vitro overexpression of microRNA-503 in endothelial cells suppressed UCP2 expression and led to a significant increase of cell mortality with decreased cell viability. Brain UCP2 downregulation is a determinant of increased stroke predisposition in high-salt-fed SHRSP. In this context, UCP2 can be modulated by both pharmacological and nutraceutical agents. The microRNA-503 significantly contributes to mediate brain UCP2 downregulation in JD-fed SHRSP

The role of morphology of the thumb in anthropomorphic grasping : a review

The unique musculoskeletal structure of the human hand brings in wider dexterous capabilities to grasp and manipulate a repertoire of objects than the non-human primates. It has been widely accepted that the orientation and the position of the thumb plays an important role in this characteristic behavior. There have been numerous attempts to develop anthropomorphic robotic hands with varying levels of success. Nevertheless, manipulation ability in those hands is to be ameliorated even though they can grasp objects successfully. An appropriate model of the thumb is important to manipulate the objects against the fingers and to maintain the stability. Modeling these complex interactions about the mechanical axes of the joints and how to incorporate these joints in robotic thumbs is a challenging task. This article presents a review of the biomechanics of the human thumb and the robotic thumb designs to identify opportunities for future anthropomorphic robotic hands