Persistent polyclonal binucleated B-cell lymphocytosis and MECOM gene amplification

BACKGROUND: Persistent Polyclonal Binucleated B-cell Lymphocytosis (PPBL) is characterized by a chronic polyclonal B-cell lymphocytosis with binucleated lymphocytes and a polyclonal increase in serum immunoglobulin-M. Cytogenetic is characterized by the presence of a supernumerary isochromosome +i(3)(q10), premature chromosome condensation and chromosomal instability. Outcome of PPBL patients is mostly benign, but subsequent malignancies could occur. The aim of our study is to provide an update of clinical and cytogenetic characteristics of our large cohort of PPBL patients, to describe subsequent malignancies occurring during the follow-up, and to investigate the role of the long arm of chromosome 3 in PPBL. RESULTS: We analyzed clinical, biological and cytogenetic characteristics (conventional cytogenetic analysis and fluorescent in situ hybridization) of 150 patients diagnosed with PPBL. We performed high-resolution SNP arrays in 10 PPBL patients, comparing CD19(+) versus CD19(−) lymphoid cells. We describe the cytogenetic characteristics in 150 PPBL patients consisting in the presence of supernumerary isochromosome +i(3)(q10) (59 %) and chromosomal instability (55 %). In CD19(+) B-cells, we observed recurrent copy number aberrations of 143 genes with 129 gains (90 %) on 3q and a common minimal amplified genomic region in the MECOM gene. After a median follow-up of 60 months, we observed the occurrence of 12 subsequent malignancies (12 %), 6 solid tumors and 6 Non-Hodgkin’s Lymphomas, and 6 monoclonal gammopathies of undetermined significance (MGUS), requiring a long-term clinical follow-up. CONCLUSIONS: Our clinical and cytogenetic observations lead us to hypothesize that isochromosome 3q, especially MECOM abnormality, could play a key role in PPBL

Etude quantitative des formes d'organisation spatiale du couvert ligneux en milieu sahélien à partir des images satellitaires SPOT

International audienc

Inside pass predicts ball possession effectiveness in NBA basketball

The aims of this study were to analyse the effects of using inside pass on ball possession effectiveness and to identify game performance indicators to predict inside pass success in the National Basketball Association (NBA), considering situational variables. A total of 4207 closed ball possessions (± 10 points difference) where recorded from 25 matches of the 2010 NBA Playoffs series. Ball possessions were classified whether including inside pass (n=808) or not (n=3399). Predictive analysis of use and effectiveness was made through a series of binomial logistic regressions and Classification tree analysis (CHAID). Results indicate that ball possessions including inside pass were more effective and longer in duration, finding a greater use in top-4 NBA teams regardless the game period. Additionally, inside pass effectiveness was influenced by: the receiver attitude, reception distance, and defensive help. Particularly, the analysis of combined performance indicators disclosed relevant information on attack effectiveness, suggesting players to adopt a dynamic attitude in the weak side before getting the ball, while their teammates are developing individual and collective actions to create free space and enhance inside game options and effectiveness. Current findings shed some light on specific knowledge concerning tactical behaviours in NBA basketball, contributing in the design of specific programmes to increase inside game options and players’ decision- making according to specific game constraints

Is the inside pass a performance indicator? : Observational analysis of elite basketball teams

The purposes of this study were: 1) to analyse the influence of inside pass on the basketball offensive success and 2) to detect the influence of both passer and receiver location, and the receiver immediate action on successful inside pass. The sample was 1324 attack phases of nine games of the 2012 Euroleague Playoff. All recorded matches were analysed by four observers. Observational methodology was used through a follow-up, ideographic, and multidimensional design approach. An ad-hoc instrument was developed in order to obtain behaviour systematic registration. For the first aim, analysed criteria were: 1) offensive effectiveness, 2) shooting zone, 3) total points scored by attack phase, 4) possession duration and 5) number of passes. For the second one: 1) passer location, 2) receiver location, and 3) immediate receiver action were registered for each inside pass attack. Multirater k free index (Randolph, 2005) was used to measure inter-observers agreement, obtaining a value over .84 in each case. In addition, intraobservers reproducibility was evaluated at the end of the observation process by calculating Cohen's Kappa, obtaining a minimum value of .90. For statistical data analysis, Mann-Whitney U test, crosstabs, Chi-square and multinomial logistic regression were carried on. The finding results show that a) those attack phase in which inside pass is done are more effective and achieve a larger amount of points, and b) passer location and immediate receiver action determinate a successful inside pass, being the outside pass with an inside reception the most effective option. These results suggest to consider the inside pass as a performance indicator in basketball.Los objetivos de este estudio fueron: 1) analizar la influencia del pase interior en el éxito del ataque y 2) detectar si la localización espacial de pasador y receptor, y la acción motriz inmediata del receptor afectan sobre el rendimiento del pase interior. Cuatro observadores analizaron un total de nueve partidos de Playoff de la Euroliga 2012, obteniendo un total de 1324 fases de ataque. Se utilizó la metodología observacional a través de un diseño de seguimiento, ideográfico y multimiensional. Se elaboró un instrumento ad-hoc para lograr un registro sistemático de las conductas de juego. Para el primer objetivo se incluyeron los siguientes criterios para cada fase de ataque: 1) eficacia ofensiva, 2) zona de lanzamiento, 3) total de puntos anotados en la fase de ataque, 4) tiempo de posesión y 5) número de pases. Para el segundo objetivo se analizó, en aquellas fases de ataque con pase interior: 1) localización espacial del pasador, 2) localización espacial del receptor y 3) acción inmediata del receptor. Se comprobó la fiabilidad interobservadores mediante el ́indice multirater k free (Randolph, 2005), obteniendo un valor por encima de .84 en cada variable. Al final del proceso se evaluó la concordancia intraobservadores mediante el Kappa de Cohen, obteniendo un valor mínimo de .90. Para el análisis estadístico se calcularon la U de Mann-Whitney, tablas de contingencia, Chi-cuadrado y regresión logística multinomial. Los resultados obtenidos muestran que 1) aquellas fases de ataque en las que se realiza el pase interior resultan más efectivas y obtienen una mayor cantidad de puntos, y 2) la localización espacial del pasador y la acción inmediata del receptor resultan determinantes en la eficacia del pase interior, siendo el pase exterior con recepción interior la opción con mayores garantías de éxito. Éstos resultados sugieren la consideración del pase interior como un indicador de rendimiento en baloncesto.Os objetivos deste estudo foram: 1) analisar a influência do passe interior no sucesso do ataque e 2) detectar se a localização espacial do passador e do receptor, bem como a ação motora imediata do receptor afetam o rendimento do passe interior. Quatro observadores analisaram um total de nove jogos nos playoffs da Euroliga 2012, obtendo um total de 1324 fases de ataque. Utilizou-se a metodologia observacional através de um delineamento de monitorização, ideográfico e multidimensional. Foi elaborado um instrumento ad-hoc para o registo sistemático de comportamentos de jogo. Para o primeiro objetivo foram incluídos os seguintes critérios para cada fase do ataque: 1) eficácia ofensiva, 2) zona de lançamento, 3) total de pontos marcados na fase de ataque, 4) tempo de posse e 5) número de passes. Para o segundo objetivo foram analisadas nas fases de ataque com passe interior: 1) localização espacial do passador, 2) localização espacial do receptor e 3) acção imediata do receptor. Verificou-se a fidelidade interobservadores através do índice multirater k livre (Randolph, 2005), obtendo-se um valor superior a .84 em cada variável. No final do processo avaliou-se a concordância intra-observadores através do Kappa de Cohen, obtendo-se um valor mínimo de .90. Para a análise estatística, foram calculados o U de Mann-Whitney, tabelas de contingência, Qui-quadrado e regressão logística multinomial. Os resultados mostram que 1) aquelas fases de ataque nas quais se realiza o passe interior são mais eficazes, obtendo-se um maior número de pontos, e 2) a localização espacial do passador e a acção imediata do receptor são determinantes na eficácia do passe interior, sendo o passe exterior com a recepção interior a opção com maiores garantias de sucesso. Estes resultados sugerem a consideração do passe interior como um indicador de rendimento no basquetebol

El efecto diferencial de la instrucción incidental e intencional en el aprendizaje de las condiciones para la decisión de tiro en baloncesto

Discriminative decision rule learning is a core ingredient in many interactive sports. This study presents a laboratory simulation experiment (an adaptation of a Go/No-go task) that focuses on the quantitative analysis of three important environmental determinants of shot selection in basketball: physical opposition, availability of rebound and availability of defensive balance. Our results show that these three criteria are incorporated into decisions at different rates. Moreover, the use of such criteria is differentially sensitive to intentional (vs. incidental) instruction. In practical terms, these results illustrate some of the potential limitations of decision-making training by mere task design, i.e., without the coach's explicit guidance

Analysis of bullying levels and its relationship with physical activity in Primary Education

Este estudio pretende conocer la relación entre la percepción de acoso entre iguales y el nivel de actividad física en estudiantes de Primaria. La muestra estuvo compuesta por 95 alumnos, con edades comprendidas entre los 9 y los 12 años, a los cuales se les administró el Cuestionario de Acoso entre Iguales y la traducción al español del Physician-based Assessment and Counseling for Exercise. Los resultados obtenidos mostraron unos niveles bajos tanto de actividad física como de percepción de acoso entre iguales. Se encontraron valores más altos de inconformismo de género y nivel de actividad física en los chicos, mientras que las chicas mostraron valores superiores en el maltrato verbal por falta de atractivo físico. Las comparaciones de nivel educativo muestran mayores niveles tanto en las conductas de acoso como en el nivel de actividad física en los alumnos de mayor edad. No se han encontrado correlaciones significativas entre el nivel de actividad física y las conductas de acosoThe objective of this study is to understand the relationship between the perception of peer harassment and the level of physical activity in primary school students. The sample consisted of 95 students, aged between 9 and 12 years, who answered the Peer Harassment Questionnaire and the translation to Spanish of the Physician-based Assessment and Counselling for Exercise to measure both variables. The results obtained showed low levels of physical activity and perception of bullying among peers were obtained. Significant differences in gender nonconformity and higher level of physical activity were found in boys, while girls showed significantly higher values in verbal abuse due to lack of physical attractiveness. Comparisons of educational level show higher levels in all areas, both of harassment and physical activity level in older students. No significant correlations have been found between the level of physical activity and bullying behaviour, so it seems that at these ages may not yet have influenc

Proof of concept of prehabilitation: a combination of education and behavioural change, to promote physical activity in people with fibromyalgia

Objectives To establish proof of concept of a prehabilitation intervention, a combination of education and behavioural change, preceding a physical activity programme in people with fibromyalgia (FM). Settings Open-label, feasibility clinical trial. Participants Eleven people with FM (10 women). Interventions The prehabilitation intervention consisted of 4 weeks, 1 weekly session (~1 to 1.5 hours), aimed to increase self-efficacy and understand why and how to engage in a gentle and self-paced physical activity programme (6 weeks of walking with telephone support). Primary and secondary outcome measures Primary outcome was the acceptability and credibility of the intervention by means of the Credibility/Expectancy Questionnaire. Secondary outcomes comprised scales to measure FM severity, specific symptoms and sedentary behaviour. An exit interview was conducted to identify the strengths and weaknesses and barriers to the intervention. Results One participant dropped out due to finding the walking programme excessively stressful. Participants expected the intervention would improve their symptoms by 22%–38% but resulted in 5%–26% improvements. Participants would be confident in recommending this intervention to a friend who experiences similar problems. The interviews suggested that the fluctuation of symptoms should be considered as an outcome and that the prehabilitation intervention should accomodate these fluctuation. Additional suggestions were to incorporate initial interviews (patient-centred approach), to tailor the programmes to individuals’ priorities and to offer a variety of physical activity programmes to improve motivation. Conclusions This feasibility study demonstrated that our novel approach is acceptable to people with FM. Future interventions should pay attention to flexibility, symptoms fluctuation and patients support.Health and Social Care Public Health Agency, Northern Ireland (STL/5268/16 to CH and JGM)Ramón y Cajal 2021 Excellence Research Grant action from the Spanish Ministry of Science and Innovation (FSE/AGENCIA ESTATAL DE INVESTIGACIÓN, RYC2021-034311- I