73,081 research outputs found

    Manufacturing Dendritic Cells for Immunotherapy: Monocyte Enrichment

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    Dendritic cells play a key role in activation of the immune system as potent antigen-presenting cells. This pivotal position, along with the ability to generate dendritic cells from monocytes and ready uptake of antigen, makes them an intriguing vehicle for immunotherapy for a variety of indications. Since the first reported trial using dendritic cells in 1995, they have been used in trials all over the world for a plethora of indications. Monocyte-derived dendritic cells are generated from whole blood or apheresis products by culturing enriched monocytes in the presence of interleukin (IL)-4 and granulocyte-macrophage colony-stimulating factor (GM-CSF). A variety of methods can be used for enrichment of monocytes for generation of clinical-grade dendritic cells and are summarized herein

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    Active diffusers : some prototypes and 2D measurements

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    Diffusing devices are used to improve room acoustics in a wide variety of applications. The dispersion generated by current diffuser technologies is often limited to mid-to-high frequencies because low-frequency diffusers are usually too large to be easily accommodated. To extend the bandwidth of diffusers to a lower frequency a new approach is proposed, that is to use active control technology. In particular, active impedance techniques have been exploited to create non-absorbing diffusers, and hybrid structures that partly absorb while dispersing any reflected sound. This paper presents results mostly from a feedforward structure. It is found that achieving active dispersion without absorption other a worthwhile bandwidth can be more difficult than achieving active absorption due to the more complex target impedance that the controller needs to learn. Measurements on polar responses provide evidence that the active diffusers can achieve wider bandwidth dispersion. Boundary element modelling has enabled the design of these structures to be examined in more application-realistic set-ups

    Spin-Flavor Separation and Non-Fermi Liquid Behavior in the Multichannel Kondo Problem: A Large N Approach

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    We consider a SU(N)×SU(M)SU(N)\times SU(M) generalization of the multichannel single-impurity Kondo model which we solve analytically in the limit NN\rightarrow \infty, MM\rightarrow\infty, with γ=M/N\gamma=M/N fixed. Non-Fermi liquid behavior of the single electron Green function and of the local spin and flavor susceptibilities occurs in both regimes, NMN\le M and N>MN > M, with leading critical exponents {\em identical} to those found in the conformal field theory solution for {\em all} NN and MM (with M2M\ge 2). We explain this remarkable agreement and connect it to ``spin-flavor separation", the essential feature of the non-Fermi-liquid fixed point of the multichannel Kondo problem.Comment: 14 pages, 1 Figure (Poscript file attached), Revte
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