CRASH - Corticosteroid Randomisation after Significant Head Injury

A large simple placebo controlled trial, among adults with head injury and impaired consciousness, of the effects of a 48-hour infusion of corticosteroids on death and neurological disability. CRASH was a randomised, controlled, double-blind trial undertaken in 239 hospitals in 49 countries. A total of 10008 adults with head injury and a Glasgow Coma Score (GCS) of 14 or less within 8 hours of injury were randomly allocated 48 hour infusion of corticosteroids (methylprednisolone) or placebo. Primary outcomes were death within 2 weeks of injury or disability at 6 months. Prespecified subgroup analyses were based on injury severity (GCS) at randomisation and on time from injury to randomisation and analysis was by intention to treat. Access to this dataset is available via https://freebird.lshtm.ac.uk/

Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study).

OBJECTIVE: To assess the effect of tranexamic acid (which reduces bleeding in surgical patients and reduces mortality due to bleeding in trauma patients) on intracranial haemorrhage in patients with traumatic brain injury. METHODS: A nested, randomised, placebo controlled trial. All investigators were masked to treatment allocation. All analyses were by intention to treat. Patients 270 adult trauma patients with, or at risk of, significant extracranial bleeding within 8 hours of injury, who also had traumatic brain injury. INTERVENTIONS: Patients randomly allocated to tranexamic acid (loading dose 1 g over 10 minutes, then infusion of 1 g over 8 hours) or matching placebo. MAIN OUTCOME MEASURES: Intracranial haemorrhage growth (measured by computed tomography) between hospital admission and then 24-48 hours later, with adjustment for Glasgow coma score, age, time from injury to the scans, and initial haemorrhage volume. RESULTS: Of the 133 patients allocated to tranexamic acid and 137 allocated to placebo, 123 (92%) and 126 (92%) respectively provided information on the primary outcome. All patients provided information on clinical outcomes. The mean total haemorrhage growth was 5.9 ml (SD 26.8) and 8.1 mL (SD 29.2) in the tranexamic acid and placebo groups respectively (adjusted difference -3.8 mL (95% confidence interval -11.5 to 3.9)). New focal cerebral ischaemic lesions occurred in 6 (5%) patients in the tranexamic acid group versus 12 (9%) in the placebo group (adjusted odds ratio 0.51 (95% confidence interval 0.18 to 1.44)). There were 14 (11%) deaths in the tranexamic acid group and 24 (18%) in the placebo group (adjusted odds ratio 0.47 (0.21 to 1.04)). CONCLUSIONS: This trial shows that neither moderate benefits nor moderate harmful effects of tranexamic acid in patients with traumatic brain injury can be excluded. However, the analysis provides grounds for further clinical trials evaluating the effect of tranexamic acid in this population. Trial registration ISRCTN86750102

20201114: Marshall University Plane Crash 50th Anniversary Materials, 2020

These items include materials from various sources, including Memorial Fountain Ceremony Booklets, Marshall Football Memorial Rededication Ceremony Programs, Posthumous Degree Ceremony Booklets, newspaper articles from The Herald Dispatch, Albany Times Union articles, and The Parthenon. This is not an exhaustive list, please download the inventory for a full list of material contents

19771109: Office of Development, 1970-1972

These items include materials from the Office of Development at Marshall University from 1970-1972 and comprise of items from or about the Marshall University Plane Crash tragedy that occurred on November 14, 1970. Items were received in 1977 and include notable materials regarding the aircraft accident report with Southern Airways, contacts with families, and the correspondence and donations from those in the community/nation to the Marshall University Memorial Fund that was established to help the families as a result of this tragedy

20201125: Marshall University Plane Crash Newspaper Clippings Collection, 1921-1982

Items from this collection are technically from an alumni member (who identified herself as part of MU-75). They were received via mail during the pandemic. Items from this collection contain materials from or about the Marshall University Plane Crash tragedy in the form of newspaper issues (the whole thing) and some other misc materials. Please download the inventory for a full list of materials

20161206: Marshall University Plane Crash Newspaper Clippings, 1970-1971

These items include materials from an unknown department on campus at Marshall University from 1970-1971 and comprise of items from or about the Marshall University Plane Crash tragedy that occurred on November 14, 1970. Items were accessioned (meaning, we either acquired it, or learned that we had it) in 2016 and include notable materials regarding the aircraft accident report with Southern Airways. These items consist of newspaper coverage of this event across the state of West Virginia, as well as national coverage. Please see inventory for full list of contents

19731100: Marshall University Plane Crash, 1970-1972

These items include materials from the Office of Development at Marshall University from 1970-1972 and comprise of items from or about the Marshall University Plane Crash tragedy that occurred on November 14, 1970. Items were received in 1973 and include notable materials regarding the aircraft accident report with Southern Airways, primarily in the form of correspondence. Please download this inventory to view the folder-level list in its entirety