Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo.

peer reviewedaudience: researcherVitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this molecule as a potential candidate for use in the prevention and treatment of skin ageing. A topically applied cream containing 5% vitamin C and its excipient were tested on healthy female volunteers presenting with photoaged skin on their low-neck and arms in view to evaluate efficacy and safety of such treatment. A double-blind, randomized trial was performed over a 6-month period, comparing the action of the vitamin C cream vs. excipient on photoaged skin. Clinical assessments included evaluation at the beginning and after 3 and 6 months of daily treatment. They were performed by the investigator and compared with the volunteer self assessment. Skin relief parameters were determined on silicone rubber replicas performed at the same time-points. Cutaneous biopsies were obtained at the end of the trial and investigated using immunohistochemistry and electron microscopy. Clinical examination by a dermatologist as well as self-assessment by the volunteers disclosed a significant improvement, in terms of the 'global score', on the vitamin C-treated side compared with the control. A highly significant increase in the density of skin microrelief and a decrease of the deep furrows were demonstrated. Ultrastructural evidence of the elastic tissue repair was also obtained and well corroborated the favorable results of the clinical and skin surface examinations. Topical application of 5% vitamin C cream was an effective and well-tolerated treatment. It led to a clinically apparent improvement of the photodamaged skin and induced modifications of skin relief and ultrastructure, suggesting a positive influence of topical vitamin C on parameters characteristic for sun-induced skin ageing

In vitro induction of melanin synthesis and extrusion by tamoxifen

Physical appearance has significant importance psychologically and socially, with skin and hair being of prime relevance. Effective ingredients that modulate melanin synthesis are of growing interest. Tamoxifen, a widely used selective oestrogen receptor modulator, SERM, was described occasionally in medical case reports as causing grey hair repigmentation. This work aimed to study, in vitro, the effect of tamoxifen and 4-hydroxy-tamoxifen, one of its most bioactive derivatives, on melanin production in human melanocytes.Teresa Matam a holds a grant from FCT–Fundação para a Ciência e a Tecnologia (SFRH/BPD/47555/2008). This work was supported by FEDER through POFC–COMPETE and by national funds from FCT through the project PEst-C/BIA/UI4050/2011

Following the strategy inside and outside the circle in the collection of material socializing with fifth graders

    The current research aims to identify the impact of the strategy of inside and outside the circle in the achievement of social studies at the fifth grade primary school .&#x0D; To achieve the point of this research the scholar applied  the null hypotheses :&#x0D;     There is no statistically difference significant between the average scores of the experimental group students who have studied the social studies by strategy of inside and outside the circle and between the average scores of the control group who studied the same material in the trditional method in the achievement .&#x0D;     The current research confined on the students of public primary day schools in Baghdad for the academic year (2016/2017), the scholar depended on a partial seizure experimental design (the experimental group and a control group of the post-test),and the scholar chose the primary shchool Ibn Al-Nadim one of the Education directorate /Al-Russafa the second / Baghdad, for the academic year (2016/2017) and that for the purpose of application the experiment , the sample consisted of (80) students , by (40) one in the experiment group that taught according to the strategy of inside and outside the circle, and (40) of the student in the control group that taught by the traditional method .&#x0D;      The scholar equalized between the two groups before starting the experience in some variables (pre-knowledge test, IQ level ), the material that going to be taught has been identified which included the first two chapters of the social studies book that going to be taught to the fifth grade primary, then the scholar formed the behavioral goals that included (80) behavioral goal in light of the overall goals and according to (Bloom) classification for the knoledge domain of three levels (knoledge, understanding, application) .&#x0D;      The scholar prepared an achievement objective test a multiple-choice type that included (30) paragraph according to the map test.&#x0D; The experience applied in the academic year (2016/2017) by three lessons per week for each group .&#x0D;     The result showed that there are statistically diffrences significant at the level of (0,05) between the average scores of the experimental group students who have studied by strategy of inside and outside the circle and between the average scores of the control group who studied the same material in the trditional method and the advantage of the experimental group in the achievement .</jats:p

Could a photobiological test be a suitable method to assess the anti-oxidant effect of a nutritional supplement Glisodin?

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Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin.

International audienceSkin ageing is a complex process determined by the genetic endowment of individual and environmental factors, such as sun exposure. The effects of skin ageing are mostly encountered in the superficial dermis and in the epidermis. We have previously demonstrated in vivo the beneficial effect of a topically applied formula of 5% vitamin C in the treatment of skin ageing. Another active compound, madecassoside extracted from Centella asiatica, known to induce collagen expression and/or to modulate inflammatory mediators, might thus prevent and correct some signs of ageing. A randomized double-blind study was carried out on photoaged skin of 20 female volunteers to investigate the effects of topically applied 5% vitamin C and 0.1% madecassoside on the clinical, biophysical and structural skin properties. After 6 months of treatment, we observed a significant improvement of the clinical score for deep and superficial wrinkles, suppleness, firmness, roughness and skin hydration. These results were corroborated by measurements of skin elasticity and semi-quantitative histological assessment of the elastic fibre network in the papillary dermis. Two-thirds of the subjects showed an improvement. The re-appearance of a normally structured elastic fibre network was observed. Our results revealed a functional and structural remodelling of chronically sun-damaged skin

Assessment of effects of an additional dietary natural mineral water uptake on skin hydration in healthy subjects by dynamic barrier function measurments and clinic scoring

International audienceBackground/aims: The purpose of this work was to develop a new sensor for objective in vivo measurement of the cutaneous temperature based on micro-electro-mechanical systems (MEMS), and to compare these performances with those of a classical thermocouple. Research on this new sensor was carried out to allow the quantification of the thermal properties of the made-up skin. Methods: Sixteen female subjects divided into two different age groups (18–35 and >50 years old) were recruited for this study. Several zones of the face and forearms were made up at random with foundations containing or not a thermoregulator raw material. The quantity of foundation applied on the skin was standardized and measurements were carried out first before make-up, and then 10 s and 5 min after make-up. The new sensor and the thermocouple were used successively on each zone. The cutaneous temperature was expressed in degrees celsius. Results/conclusion: The two systems are similar in terms of repeatability and reproducibility, with some differences in sensibility. The data measured by the MEMS sensor appear lower than those measured by the thermocouple. After make-up, the MEMS sensor detects a progressive increase of the temperature in time whereas the thermocouple detects a decrease. We found the same evolution on the face but in a more attenuated way. These results tend to show that the devices do not measure the same phenomenon. The thermocouple appears more sensitive to the thermal response of the made-up surface whereas the MEMS sensor appears more sensitive to the heat transfers in the interface between the skin and make-up