Defining adaptation in a generic multi layer model : CAM: the GRAPPLE conceptual adaptation model

Authoring of Adaptive Hypermedia is a difficult and time consuming task. Reference models like LAOS and AHAM separate adaptation and content in different layers. Systems like AHA! offer graphical tools based on these models to allow authors to define adaptation without knowing any adaptation language. The adaptation that can be defined using such tools is still limited. Authoring systems like MOT are more flexible, but usability of adaptation specification is low. This paper proposes a more generic model which allows the adaptation to be defined in an arbitrary number of layers, where adaptation is expressed in terms of relationships between concepts. This model allows the creation of more powerful yet easier to use graphical authoring tools. This paper presents the structure of the Conceptual Adaptation Models used in adaptive applications created within the GRAPPLE adaptive learning environment, and their representation in a graphical authoring tool

Defining adaptation in a generic multi layer model : CAM: the GRAPPLE conceptual adaptation model

Authoring of Adaptive Hypermedia is a difficult and time consuming task. Reference models like LAOS and AHAM separate adaptation and content in different layers. Systems like AHA! offer graphical tools based on these models to allow authors to define adaptation without knowing any adaptation language. The adaptation that can be defined using such tools is still limited. Authoring systems like MOT are more flexible, but usability of adaptation specification is low. This paper proposes a more generic model which allows the adaptation to be defined in an arbitrary number of layers, where adaptation is expressed in terms of relationships between concepts. This model allows the creation of more powerful yet easier to use graphical authoring tools. This paper presents the structure of the Conceptual Adaptation Models used in adaptive applications created within the GRAPPLE adaptive learning environment, and their representation in a graphical authoring tool

Authoring of Adaptive and Adaptable Hypermedia

Authoring of Adaptive Hypermedia has been long considered as secondary to adaptive hypermedia delivery. However, authoring is not trivial at all. There exist some approaches to help authors to build adaptive-hypermedia-based systems, yet there is a strong need for high-level approaches, formalisms and tools that support and facilitate the description of reusable adaptive websites. Only recently have we noticed a shift in interest, as it became clearer that the implementation-oriented approach would forever keep adaptive hypermedia away from the ‘layman’ author. The creator of adaptive hypermedia cannot be expected to know all facets of this process, but can be reasonably trusted to be an expert in one of them. It is therefore necessary to research and establish the components of an adaptive hypermedia system from an authoring perspective, catering for the different author personas that are required. This type of research has proven to lead to a modular view on the adaptive hypermedia

Systematic discovery of structural elements governing stability of mammalian messenger RNAs.

Decoding post-transcriptional regulatory programs in RNA is a critical step towards the larger goal of developing predictive dynamical models of cellular behaviour. Despite recent efforts, the vast landscape of RNA regulatory elements remains largely uncharacterized. A long-standing obstacle is the contribution of local RNA secondary structure to the definition of interaction partners in a variety of regulatory contexts, including--but not limited to--transcript stability, alternative splicing and localization. There are many documented instances where the presence of a structural regulatory element dictates alternative splicing patterns (for example, human cardiac troponin T) or affects other aspects of RNA biology. Thus, a full characterization of post-transcriptional regulatory programs requires capturing information provided by both local secondary structures and the underlying sequence. Here we present a computational framework based on context-free grammars and mutual information that systematically explores the immense space of small structural elements and reveals motifs that are significantly informative of genome-wide measurements of RNA behaviour. By applying this framework to genome-wide human mRNA stability data, we reveal eight highly significant elements with substantial structural information, for the strongest of which we show a major role in global mRNA regulation. Through biochemistry, mass spectrometry and in vivo binding studies, we identified human HNRPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1, also known as HNRNPA2B1) as the key regulator that binds this element and stabilizes a large number of its target genes. We created a global post-transcriptional regulatory map based on the identity of the discovered linear and structural cis-regulatory elements, their regulatory interactions and their target pathways. This approach could also be used to reveal the structural elements that modulate other aspects of RNA behaviour

On the number of solutions of a transcendental equation arising in the theory of gravitational lensing

The equation in the title describes the number of bright images of a point source under lensing by an elliptic object with isothermal density. We prove that this equation has at most 6 solutions. Any number of solutions from 1 to 6 can actually occur.Comment: 26 pages, 12 figure

Creep-Fatigue Crack Growth in Power Plant Components

In components operating at high temperature, the presence of defect, that may derive from manufacturing process or operating under critical conditions, could raise to creep-fatigue crack growth even at low loading conditions. Creep- fatigue experimental tests have been performed on P91 material, at 600 °C according to ASTM E2760-10 standard, with focus on the effects of the initial nominal stress intensity factor range, ranging between 16 and 22 MPa m 0.5, and the hold time, ranging between 0.1 and 10 hours. The results will be presented in the paper, together with their application for residual life prediction of a power plant cracked pipe, as case study

Evaluation of social personalized adaptive E-Learning environments : end-user point of view

The use of adaptations, along with the social affordances of collaboration and networking, carries a great potential for improving e-learning experiences. However, the review of the previous work indicates current e-learning systems have only marginally explored the integration of social features and adaptation techniques. The overall aim of this research, therefore, is to address this gap by evaluating a system developed to foster social personalized adaptive e-learning experiences. We have developed our first prototype system, Topolor, based on the concepts of Adaptive Educational Hypermedia and Social E-Learning. We have also conducted an experimental case study for the evaluation of the prototype system from different perspectives. The results show a considerably high satisfaction of the end users. This paper reports the evaluation results from end user point of view, and generalizes our method to a component-based evaluation framework

MOT meets AHA!

MOT (My Online Teacher) is an adaptive hypermedia system (AHS) web-authoring environment. MOT is now being further developed according to the LAOS five-layer adaptation model for adaptive hypermedia and adaptive web-material, containing a domain -, goal -, user -, adaptation – and presentation model. The adaptation itself follows the LAG three-layer granularity structure, figuring direct adaptation techniques and rules, an adaptation language and adaptation strategies. In this paper we shortly describe the theoretical basis of MOT, i.e., LAOS and LAG, and then give some information about the current state of MOT. The purpose of this paper is to show how we plan the design and development of MOT and the well-known system AHA! (Adaptive Hypermedia Architecture), developed at the Technical University of Eindhoven since 1996. We aim especially at the integration with AHA! 2.0. Although AHA! 2.0 represents a progress when compared to the previous versions, a lot of adaptive features that are described by the LAOS and the adaptation granulation model and that are being implemented into MOT are not yet (directly) available. So therefore AHA! can benefit from MOT. On the other hand, AHA! offers a running platform for the adaptation engine, which can benefit MOT in return

Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix.

The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by phosphorylation. However, the role of Rb phosphorylation by cyclin D-Cdk4,6 in cell-cycle progression is unclear because Rb can be phosphorylated by other cyclin-Cdks, and cyclin D-Cdk4,6 has other targets involved in cell division. Here, we show that cyclin D-Cdk4,6 docks one side of an alpha-helix in the Rb C terminus, which is not recognized by cyclins E, A, and B. This helix-based docking mechanism is shared by the p107 and p130 Rb-family members across metazoans. Mutation of the Rb C-terminal helix prevents its phosphorylation, promotes G1 arrest, and enhances Rb's tumor suppressive function. Our work conclusively demonstrates that the cyclin D-Rb interaction drives cell division and expands the diversity of known cyclin-based protein docking mechanisms

Lattice Boltzmann study on Kelvin-Helmholtz instability: the roles of velocity and density gradients

A two-dimensional lattice Boltzmann model with 19 discrete velocities for compressible Euler equations is proposed (D2V19-LBM). The fifth-order Weighted Essentially Non-Oscillatory (5th-WENO) finite difference scheme is employed to calculate the convection term of the lattice Boltzmann equation. The validity of the model is verified by comparing simulation results of the Sod shock tube with its corresponding analytical solutions. The velocity and density gradient effects on the Kelvin-Helmholtz instability (KHI) are investigated using the proposed model. Sharp density contours are obtained in our simulations. It is found that, the linear growth rate $\gamma$ for the KHI decreases with increasing the width of velocity transition layer ${D_{v}}$ but increases with increasing the width of density transition layer ${D_{\rho}}$. After the initial transient period and before the vortex has been well formed, the linear growth rates, $\gamma_v$ and $\gamma_{\rho}$, vary with ${D_{v}}$ and ${D_{\rho}}$ approximately in the following way, $\ln\gamma_{v}=a-bD_{v}$ and $\gamma_{\rho}=c+e\ln D_{\rho} ({D_{\rho}}<{D_{\rho}^{E}})$, where $a$, $b$, $c$ and $e$ are fitting parameters and ${D_{\rho}^{E}}$ is the effective interaction width of density transition layer. When ${D_{\rho}}>{D_{\rho}^{E}}$ the linear growth rate $\gamma_{\rho}$ does not vary significantly any more. One can use the hybrid effects of velocity and density transition layers to stabilize the KHI. Our numerical simulation results are in general agreement with the analytical results [L. F. Wang, \emph{et al.}, Phys. Plasma \textbf{17}, 042103 (2010)].Comment: Accepted for publication in PR