Low in‑hospital mortality rate in patients with COVID‑19 receiving thromboprophylaxis: data from the multicentre observational START‑COVID Register

Abstract COVID-19 infection causes respiratory pathology with severe interstitial pneumonia and extra-pulmonary complications; in particular, it may predispose to thromboembolic disease. The current guidelines recommend the use of thromboprophylaxis in patients with COVID-19, however, the optimal heparin dosage treatment is not well-established. We conducted a multicentre, Italian, retrospective, observational study on COVID-19 patients admitted to ordinary wards, to describe clinical characteristic of patients at admission, bleeding and thrombotic events occurring during hospital stay. The strategies used for thromboprophylaxis and its role on patient outcome were, also, described. 1091 patients hospitalized were included in the START-COVID-19 Register. During hospital stay, 769 (70.7%) patients were treated with antithrombotic drugs: low molecular weight heparin (the great majority enoxaparin), fondaparinux, or unfractioned heparin. These patients were more frequently affected by comorbidities, such as hypertension, atrial fibrillation, previous thromboembolism, neurological disease,and cancer with respect to patients who did not receive thromboprophylaxis. During hospital stay, 1.2% patients had a major bleeding event. All patients were treated with antithrombotic drugs; 5.4%, had venous thromboembolism [30.5% deep vein thrombosis (DVT), 66.1% pulmonary embolism (PE), and 3.4% patients had DVT + PE]. In our cohort the mortality rate was 18.3%. Heparin use was independently associated with survival in patients aged ≥ 59 years at multivariable analysis. We confirmed the high mortality rate of COVID-19 in hospitalized patients in ordinary wards. Treatment with antithrombotic drugs is significantly associated with a reduction of mortality rates especially in patients older than 59 years

Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both

Background and objective: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from the REPOSI register, we evaluated the clinical features and outcomes in a population of elderly patients admitted to internal medicine wards and having COPD, HF or COPD + HF. Methods: We measured socio-demographic and anthropometric characteristics, severity and prevalence of comorbidities, clinical and laboratory features during hospitalization, mood disorders, functional independence, drug prescriptions and discharge destination. The primary study outcome was the risk of death. Results: We considered 2,343 elderly hospitalized patients (median age 81 years), of whom 1,154 (49%) had COPD, 813 (35%) HF, and 376 (16%) COPD + HF. Patients with COPD + HF had different characteristics than those with COPD or HF, such as a higher prevalence of previous hospitalizations, comorbidities (especially chronic kidney disease), higher respiratory rate at admission and number of prescribed drugs. Patients with COPD + HF (hazard ratio HR 1.74, 95% confidence intervals CI 1.16-2.61) and patients with dementia (HR 1.75, 95% CI 1.06-2.90) had a higher risk of death at one year. The Kaplan-Meier curves showed a higher mortality risk in the group of patients with COPD + HF for all causes (p = 0.010), respiratory causes (p = 0.006), cardiovascular causes (p = 0.046) and respiratory plus cardiovascular causes (p = 0.009). Conclusion: In this real-life cohort of hospitalized elderly patients, the coexistence of COPD and HF significantly worsened prognosis at one year. This finding may help to better define the care needs of this population

Sound Recording - Historica Critica; Marvin Niehuss, Harlan Hatcher, and Donald Rucknagel - 1986 May 27

Content note: The sound recording(s) associated with this repository item derive from a single audio reel tape. A single tape may yield multiple audio files if there were variations in tape stock, speed, or channels (i.e. stereo or mono). For more information see http://hdl.handle.net/2027.42/108126.[Program 6] : [Item 3] : [Part 1] : Tape 3; Unidentified speaker discussing Harlan Hatcher's firing of Professors who were identified as Communists and the investigation by the House Un-American Activities Committee.http://deepblue.lib.umich.edu/bitstream/2027.42/122313/2/90139-SR-6-3-1-am.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/122313/3/90139-SR-6-3-1-pm.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/122313/4/90139-SR-6-3-1.mp3http://deepblue.lib.umich.edu/bitstream/2027.42/122313/5/90139-SR-6-3-1-001.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122313/6/90139-SR-6-3-1-002.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122313/7/90139-SR-6-3-1-003.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122313/8/90139-SR-6-3-1-notes.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/122313/9/90139-SR-6-3-1.xmlRESTRICTE

Contaminaditos y en riesgo

This is a news story in “Criticadigital.com” at http://criticadigital.com/. It talks about environmental contamination in various places in Argentina and mentions Abra Pampa specifically.La

Sound Recording - Historica Critica; Wilbur Pierpont - [Undated]

Content note: The sound recording(s) associated with this repository item derive from a single audio reel tape. A single tape may yield multiple audio files if there were variations in tape stock, speed, or channels (i.e. stereo or mono). For more information see http://hdl.handle.net/2027.42/108126.[Program 7] : [Item 1] : [Part 1] : Interview with Wilbur Pierpont, Vice-President of Finance, ends with discussion of long range planning, including a discussion of North Campus proposals and solutionshttp://deepblue.lib.umich.edu/bitstream/2027.42/122314/2/90139-SR-7-1-1-am.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/122314/3/90139-SR-7-1-1-pm.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/122314/4/90139-SR-7-1-1.mp3http://deepblue.lib.umich.edu/bitstream/2027.42/122314/5/90139-SR-7-1-1-003.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122314/6/90139-SR-7-1-1-004.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122314/7/90139-SR-7-1-1-002.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122314/8/90139-SR-7-1-1-001.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122314/9/90139-SR-7-1-1-notes.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/122314/10/90139-SR-7-1-1.xmlRESTRICTE

Sound Recording - Historica Critica; Myron Wegman, John Sears - 1986 June 10

Content note: The sound recording(s) associated with this repository item derive from a single audio reel tape. A single tape may yield multiple audio files if there were variations in tape stock, speed, or channels (i.e. stereo or mono). For more information see http://hdl.handle.net/2027.42/108126.[Program 10] : [Item 3] : [Part 1] : Tape 3; Interview with Myron Wegman (Professor of Public Health) and John Sears (Professor in Medical School); Discussion of tenure by-laws and problems with medical schoolhttp://deepblue.lib.umich.edu/bitstream/2027.42/122302/2/90139-SR-10-3-1-am.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/122302/3/90139-SR-10-3-1-pm.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/122302/4/90139-SR-10-3-1.mp3http://deepblue.lib.umich.edu/bitstream/2027.42/122302/5/90139-SR-10-3-1-003.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122302/6/90139-SR-10-3-1-001.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122302/7/90139-SR-10-3-1-002.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122302/8/90139-SR-10-3-1-notes.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/122302/9/90139-SR-10-3-1.xmlRESTRICTE

Sound Recording - Historica Critica; William Dow - 1986 May 13

Content note: The sound recording(s) associated with this repository item derive from a single audio reel tape. A single tape may yield multiple audio files if there were variations in tape stock, speed, or channels (i.e. stereo or mono). For more information see http://hdl.handle.net/2027.42/108126.[Program 2] : [Item 1] : [Part 1] : Tape 1; Interview with William Dow (Professor of Electrical Engineering) about his experiences at the University of Michigan.http://deepblue.lib.umich.edu/bitstream/2027.42/122303/2/90139-SR-2-1-1-am.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/122303/3/90139-SR-2-1-1-pm.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/122303/4/90139-SR-2-1-1.mp3http://deepblue.lib.umich.edu/bitstream/2027.42/122303/5/90139-SR-2-1-1-003.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122303/6/90139-SR-2-1-1-001.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122303/7/90139-SR-2-1-1-002.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122303/8/90139-SR-2-1-1-notes.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/122303/9/90139-SR-2-1-1.xmlRESTRICTE

Sound Recording - Historica Critica; Myron Wegman, John Sears - 1986 June 10

Content note: The sound recording(s) associated with this repository item derive from a single audio reel tape. A single tape may yield multiple audio files if there were variations in tape stock, speed, or channels (i.e. stereo or mono). For more information see http://hdl.handle.net/2027.42/108126.[Program 10] : [Item 1] : [Part 1] : Tape 1; Interview with Myron Wegman (Professor of Public Health) discussing his experiences at the University of Michigan.http://deepblue.lib.umich.edu/bitstream/2027.42/122300/2/90139-SR-10-1-1-am.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/122300/3/90139-SR-10-1-1-pm.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/122300/4/90139-SR-10-1-1.mp3http://deepblue.lib.umich.edu/bitstream/2027.42/122300/5/90139-SR-10-1-1-004.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122300/6/90139-SR-10-1-1-003.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122300/7/90139-SR-10-1-1-002.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122300/8/90139-SR-10-1-1-001.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122300/9/90139-SR-10-1-1-notes.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/122300/10/90139-SR-10-1-1.xmlRESTRICTE

Sound Recording - Historica Critica; Wesley Maurer - 1985 April 19

Content note: The sound recording(s) associated with this repository item derive from a single audio reel tape. A single tape may yield multiple audio files if there were variations in tape stock, speed, or channels (i.e. stereo or mono). For more information see http://hdl.handle.net/2027.42/108126.[Program 5] : [Item 2] : [Part 1] : Tape 2; Interview with Wesley Maurer (Professor of Journalism), discussing McCarthyism and the firings of professors at UM during the Red Scare.http://deepblue.lib.umich.edu/bitstream/2027.42/122310/2/90139-SR-5-2-1-am.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/122310/3/90139-SR-5-2-1-pm.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/122310/4/90139-SR-5-2-1.mp3http://deepblue.lib.umich.edu/bitstream/2027.42/122310/5/90139-SR-5-2-1-003.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122310/6/90139-SR-5-2-1-002.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122310/7/90139-SR-5-2-1-001.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/122310/8/90139-SR-5-2-1-notes.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/122310/9/90139-SR-5-2-1.xmlRESTRICTE