A University Course to Facilitate the Transition Into, Through, and Beyond College Life

The purpose of this project was to review the literature associated with the social and psychological adjustments freshmen and transfer intercollegiate athletes face as they transition into college and create a mandatory course to assist them through their transition into California Polytechnic State University. This project led to the creation of an academic course that will be offered at California Polytechnic State University in the near future. This course could serve as an impetus for coaches, faculty, and administrators at other universities to develop similar courses, or reevaluate established course offerings, and to develop follow-up course training for intercollegiate athletes that will contribute to their positive growth throughout the course of their college careers

Genetic determinants of cortical structure (thickness, surface area and volumes) among disease free adults in the CHARGE Consortium

Cortical thickness, surface area and volumes (MRI cortical measures) vary with age and cognitive function, and in neurological and psychiatric diseases. We examined heritability, genetic correlations and genome-wide associations of cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprised 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the United Kingdom Biobank. Significant associations were replicated in the Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) consortium, and their biological implications explored using bioinformatic annotation and pathway analyses. We identified genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There was enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging

Children's work in family and community contexts: Examples from Young Lives Ethiopia

In this paper we present findings on the place of work in the lives of children. These findings come from a study carried out with children in three Ethiopian communities, in two cities and one rural area. We describe the types of work done by boys and girls of different ages, and show how these children seek to combine work with school. We find that, with changes in the economic contexts, some children started paid work as early as 8 years old but that most younger children were mainly involved in work for the household. Gender differences become more prominent with age: compared to boys, older girls routinely take on greater responsibility for household chores and care activities; going to school or undertaking paid work does not diminish their household responsibilities. Based on the findings we suggest that social protection policies and programmes should provide insurance against community and household shocks and support children in affected households. Flexible learning arrangements can enable children who are working to continue with schooling

‘Motherhood in childhood’: Generational change in Ethiopia

This article explores the changing place of ‘motherhood’ in the lives of girls and young women in Ethiopia, from a generational, life course perspective. It focuses on ‘motherhood in childhood’ in the context of rapid social change, drawing on multi-generational narratives from young women, their mothers and grandmothers, as part of Young Lives, a fifteen-year study that has traced the life trajectories of a group of girls growing up in poverty. Marriage and motherhood in childhood in past generations was the norm but has increasingly come to be seen as incompatible with the expectations for modern female childhood. A growing discourse of female empowerment suggests significant expansion of ‘choice’ for girls, but closer inspection of girls’ lived experiences of marriage and motherhood suggests a more complex, uneven, picture. Girls face multiple, sometimes contradictory messages regarding the kinds of respectable life paths they should pursue. Their sense of expanded horizons in childhood is easily diminished when they become young mothers, highlighting the persistent influence of poverty and the feminisation of reproductive roles and the ambiguous nature of their agency across time

The use of visual methods to explore how children construct and assign meaning to the ''self'' within two urban communities in the Western Cape, South Africa

This study aimed to explore how children construct and assign meaning to the ''self'' within two urban communities of Cape Town in South Africa. Using a child participation methodological framework data were collected using Photovoice and community maps with 54 participants between the ages of 9 and 12. Feelings of safety, social connectedness, and children's spaces were found to be central to the ways in which the participants constructed and assigned meaning to the ''self.'' The study provides implications for intervention programmes aimed at improving children's well-being to be inclusive of activities aimed at improving children's self-concept, including the construction of safe spaces for children to play, learn, and form meaningful relationships

Child work and labour in Ethiopia: literature review and policy implications

This chapter aims to provide a preliminary bibliographical resource, an initial critical review of the literature, new insights on child work and labour in Ethiopia, and suggestions for future lines of research. The first part considers the different disciplinary and methodological approaches used to study the issues; we suggest that the various disciplinary lenses through which child work and labour have been studied result in a fragmented rather than an integrated picture. Moreover, we argue that there is a dichotomy between quantitative approaches, many of which have focused on rural surveys and the linkages between child work and education, and qualitative approaches that have concentrated on urban areas and vulnerable children. The second part briefly reviews findings from quantitative research notably on the prevalence of child work and its distribution, children’s time use and their contribution to the household economy, the impacts of government rural development and food security programmes on child work, and the implications of work for children’s health and wellbeing. The third part considers key findings from qualitative research on the work that children do, in particular that of children at risk focusing on the main categories studied, and discusses the value and meaning of work and changing work norms. The fourth part considers the policy context, international and national legal frameworks, policies and action plans. The fifth part considers interventions within the country to address child labour. The final part draws overall conclusions and identifies research gaps

Impact of TGF-ß1 -509C/T and 869T/C polymorphisms on glioma risk and patient prognosis

Transforming growth factor beta (TGF-ß) plays an important role in carcinogenesis. Two polymorphisms in the TGF-ß1 gene (-509C/T and 869T/C) were described to influence susceptibility to gastric and breast cancers. The 869T/C polymorphism was also associated with overall survival in breast cancer patients. In the present study, we investigated the relevance of these TGF-ß1 polymorphism in glioma risk and prognosis. A case-control study that included 114 glioma patients and 138 cancer-free controls was performed. Single nucleotide polymorphisms (SNPs) were evaluated by polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP). Univariate and multivariate logistic regression analyses were used to calculate odds ratio (OR) and 95 % confidence intervals (95 % CI). The influence of TGF-ß1 -509C/T and 869T/C polymorphisms on glioma patient survival was evaluated by a Cox regression model adjusted for patients' age and sex and represented in Kaplan-Meier curves. Our results demonstrated that TGF-ß1 gene polymorphisms -509C/T and 869T/C are not significantly associated with glioma risk. Survival analyses showed that the homozygous -509TT genotype associates with longer overall survival of glioblastoma (GBM) patients when compared with patients carrying CC + CT genotypes (OR, 2.41; 95 % CI, 1.06-5.50; p = 0.036). In addition, the homozygous 869CC genotype is associated with increased overall survival of GBM patients when compared with 869TT + TC genotypes (OR, 2.62; 95 % CI, 1.11-6.17; p = 0.027). In conclusion, this study suggests that TGF-ß1 -509C/T and 869T/C polymorphisms are not significantly associated with risk for developing gliomas but may be relevant prognostic biomarkers in GBM patients.This work was supported by Fundação para a Ciência e Tecnologia, Portugal (PTDC/SAU-GMG/113795/2009 and SFRH/BPD/33612/2009 to B.M.C.; SFRH/BD/88121/2012 to J.V.C.; SFRH/BD/92786/2013 to C.S.G.; PTDC/SAU-ONC/115513/2009 to R.R.)