2,179 research outputs found
Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes.
Analyses of TCR-bearing murine and human T cells have defined a unique subpopulation of T cells that express the TCR-gamma/delta proteins. The specificity of TCR-gamma/delta T cells and their role in the immune response have not yet been elucidated. Here we examine alloreactive TCR-gamma/delta T cell lines and clones that recognize MHC-encoded antigens. A BALB/c nu/nu (H-2d)-derived H-2k specific T cell line and derived clones were both cytolytic and released lymphokines after recognition of a non-classical H-2 antigen encoded in the TL region of the MHC. These cells expressed the V gamma 2/C gamma 1 protein in association with a TCR-delta gene product encoded by a Va gene segment rearranged to two D delta and one J delta variable elements. A second MHC-specific B10 nu/nu (H-2b) TCR-gamma/delta T cell line appeared to recognize a classical H-2D-encoded MHC molecule and expressed a distinct V gamma/C gamma 4-encoded protein. These data suggest that many TCR-gamma/delta-expressing T cells may recognize MHC-linked antigens encoded within distinct subregions of the MHC. The role of MHC-specific TCR-gamma/delta cells in immune responses and their immunological significance are discussed
Placement of a temporary pacemaker electrode through a persistent left superior vena cava
Perioperative temporary pacing was needed in a patient with congenital skeletal malformations and a cardiac conduction disturbance with incomplete trifascicular block. We report the successful placement of the pacemaker electrode through a persistent left superior vena cava (SVC
UA94/6/1 Gemini 14 USO Show
Press kit created by the USO to promote Gemini 14. Includes photo of the band, list of members, set list and biographical sketches of members
Dynamical Coulomb blockade of multiple Andreev reflections
We analyze the dynamical Coulomb blockade of multiple Andreev reflections
(MAR) in a superconducting quantum point contact coupled to a macroscopic
impedance. We find that at very low transmission the blockade scales as
with , where is the bias voltage and is the
superconducting gap, as it would correspond to the occurrence of "shots" of
charge . For higher transmission the blockade is reduced both due to Pauli
principle and to elastic renormalization of the MAR probability, and for
certain voltage regions it may even become an "antiblockade", i.e. the current
is enhanced due to the coupling with the electromagnetic environment.Comment: 5 pages, 4 figures, submitted to Phys. Rev. Let
A one-channel conductor in an ohmic environment: mapping to a TLL and full counting statistics
It is shown that a one-channel mesoscopic conductor in an ohmic environment
can be mapped to the problem of a backscattering impurity in a
Tomonaga-Luttinger liquid (TLL). This allows to determine non perturbatively
the effect of the environment on curves, and to find an exact
relationship between dynamic Coulomb blockade and shot noise. We investigate
critically how this relationship compares to recent proposals in the
literature. The full counting statistics is determined at zero temperature.Comment: 5 pages, 2 figures, shortened version for publication in Phys. Rev.
Let
A Simple Regime-Switching Model for Stochastic Volatilities
In this paper, a simple Markov switching model for the volatility of financial returns is presented. We discuss a moment estimation procedure and develop forecasts for future squared volatilities.Stochastic volatilities, Markov regime switching, Moment estimatior.
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