Principles for Fair & Equitable Federal Infrastructure Investments

This infographic shows NI's principles for ensuring fair and equitable federal infrastructure investments, including investments that benefit low-income communities, communities of color, and individuals facing barriers to employment.

Abuse, Neglect, and Exploitation of Vulnerable Elders

Educational Objectives 1. To describe the variety and dynamics of self-neglect and abuse. 2. To illustrate cases of familial self-neglect and of financial exploitation. 3. To demonstrate the roles that Adult Protective Services (APS) plays in the investigation of adult abuse, neglect, and exploitation. 4. To describe the protections available to vulnerable adults in the Commonwealth

Young peoples' views of online historical archives

Digitized collections are ‘a rich source of instructional material for history teachers’ [1 p314] but it has been noted these ‘remained largely underused’. There is ‘a growing interest in both improving the user experience and in justifying the creation of digital collections to multiple stakeholders’ [2 p339]. Within the UK an estimated £130m has been invested in digitisation projects [3]. Re-cent changes to the UK National Curriculum for history have placed greater emphasis upon the importance of understanding methods of historical enquiry and the use of evidence. Therefore, the digitized collections created by this investment should be a vital classroom tool. This study set out to investigate within the UK the level of awareness of these resources and their value to young learners aged 8-16 years. There were two stages to this qualitative study. Stage one was the delivery of a workshop which introduced young learners to a range of digital archives. After this the young people were given a period of time to use the online archives and explore the difference forms of historical evidence. Stage two involved focus groups with a sample of the young people during which participants were asked to discuss their end-user experience. Key findings included enhanced personal learning experience, development of a personal connection to the past, and identification of issues related to usability and practical application in a classroom learning context

Taxation and Public Finance in South Dakota

Of the many problems that confront the American people at the present time, few are entitled to and are receiving as much consideration and study as that of taxation and public finance. The proper financing of local and state government is an important and serious problem which directly affects the prosperity and happiness of all citizens. Taxation has always been a live question. Taxes represent expenditures for group purposes rather than for the private purposes of the specific individuals paying them. Therefore, the benefits and services secured through them are not as directly recognizable as are the benefits or services secured by private expenditure. Neither is it as easy for the individual to determine the merits of any given public expenditure as it is for him to decide whether a private purchase or payment will warrant his making the necessary expenditure for it

Investigation of Variability in Cognitive State Assessment based on Electroencephalogram-derived Features

To implement adaptive aiding in modern aviation systems there is a need for accurate and reliable classification of cognitive workload. Using electroencephalogram (EEG)-derived features, it has been reported that an Artificial Neural Network (ANN) can achieve 95% or higher classification accuracy on the same day for an individual operator, but only 70% or less on a different day. To gain a further insight into this discrepancy, data from a previous study was utilized to study the classification variability. The EEG-derived features were first calculated by spectral power estimation. The variability was then analyzed by performing cognitive workload classification in which different methods of training and testing were used and different classifiers were implemented to compare classification accuracies. The classifiers include an ANN, Adaboost Algorithm, and a t-test method. The results show that when the ANN or Adaboost method is used, the amount of overlapping among training and testing data impacts the classification accuracy significantly. When there is no overlap, all classifiers can only achieve an accuracy of about 70%, with the Adaboost outperforming other classifiers slightly. By allowing some overlap, the accuracy of the ANN or Adaboost method increases significantly. It was concluded that the main source of the classification variability is the inherent variability of the EEG-derived features

Drug-related activity in the United Kingdom of Great Britain and Ireland between 1900 and 1922: what evidence can be found through systematic searches of the Times digital achive.

Much has been written about drug-taking during the nineteenth century, particularly in relation to opium. However, the early twentieth century has received considerably less attention, despite being a crucial period in the history of drug-taking within Britain. During 1916, the Defence of the Realm Act Regulation 40b made it an offence to supply or to possess particular drugs without authorisation. This was a fundamental shift in government thinking that presaged the modern era in which the legal status of particular drugs continues to be an issue of public debate. Previous research focused on changes in the law and analysed the relationships between key individuals and influential groups with an interest in drug control. In part, this reflects the significance of the decision to alter the law but also the lack of available evidence concerning drug-takers of the era. This study seeks to address this gap in understanding and develops a new perspective on drug-taking, that of the participants. The study developed an innovative and, at times, speculative approach to tracing drug-takers of that era. This led to the use of articles from The Times identified from systematic searches of The Times Digital Archive. These articles by their nature were mediated accounts of drug-related activity but no other source could offer such a range of drug-takers over the selected time period (1900-1922). Furthermore, the large number of articles identified meant that it was easier to detect press influences and take these into account when analysing their content. The wealth of information that emerged from the articles was beyond initial expectations and led to an additional piece of analysis concerning the geographical spread of drug-taking activity within the period. Although the evidence did not allow the development of many in-depth accounts as had been the intention at the outset, it did provide insight to particular aspects of drug-taking activity. For example, the collated information regarding female participants suggested specific behavioural traits that possibly made female consumers harder to detect compared to their male counterparts. Drug-taking among military personnel and the operation of supply networks were other aspects illuminated by the articles. An association emerged between military conflicts and increased drug-taking by military personnel. It indicated, too, that periods of conflict could have implications for domestic prevalence from the cessation of hostilities. Geographical analysis illuminated the supply networks both in terms of drug procurement and relationships between drug-takers within their areas of settlement. Furthermore, some of the areas associated with drug-taking during the early twentieth century remain linked to drugs in the present day raising questions about how and why specific areas might become drug hot-spots. Further research arising from this thesis would involve the replication of the method during the later period, 1923 to 1950. This period would allow the female narrative of drug-related activity begun by this thesis to be developed further and to establish whether the First World War was a unique period for female participation or whether their participation evolved. Similarly, considering the articles from this later period could help illuminate further the subsequent spread and operation of supply networks. Replicating the method would also test whether it is transferable to other periods or whether changes to reporting style made the method era specific

AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats

© 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).Glioblastoma is a kind of malignant tumour and originates from the central nervous system. In the last century, some researchers and clinician have noticed that the psychosocial and neurocognitive functioning of patients with malignant gliomas can be impaired. Many clinical studies have demonstrated that part of patients, adults or children, diagnosed with glioblastoma will suffer from cognitive deficiency during their clinical course, especially in long-term survivors. Many nanoparticles (NPs) can inhibit the biological functions of tumours by modulating tumour-associated inflammation, which provokes angiogenesis and tumour growth. As one of the best antiviral nanoparticles (AVNPs), AVNP2 is the 2nd generation of AVNP2 that have been conjugated to graphite-graphene for improving physiochemical performance and reducing toxicity. AVNP2 inactivates viruses, such as the H1N1 and H5N1influenza viruses and even the SARS coronavirus, while it inhibits bacteria, such as MRSA and E. coli. As antimicrobials, nanoparticles are considered to be one of the vectors for the administration of therapeutic compounds. Yet, little is known about their potential functionalities and toxicities to the neurotoxic effects of cancer. Herein, we explored the functionality of AVNP2 on inhibiting C6 in glioma-bearing rats. The novel object-recognition test and open-field test showed that AVNP2 significantly improved the neuro-behaviour affected by C6 glioma. AVNP2 also alleviated the decline of long-term potentiation (LTP) and the decreased density of dendritic spines in the CA1 region induced by C6. Western blot assay and immunofluorescence staining showed that the expressions of synaptic-related proteins (PSD-95 and SYP) were increased, and these findings were in accordance with the results mentioned above. It revealed that the sizes of tumours in C6 glioma-bearing rats were smaller after treatment with AVNP2. The decreased expression of inflammatory factors (IL-1β, IL-6 and TNF-α) by Western blotting assay and ELISA, angiogenesis protein (VEGF) by Western blotting assay and other related proteins (BDNF, NF-ĸB, iNOS and COX-2) by Western blotting assay in peri-tumour tissue indicated that AVNP2 could control tumour-associated inflammation, thus efficiently ameliorating the local inflammatory condition and, to some extent, inhibiting angiogenesis in C6-bearing rats. In conclusion, our results suggested that AVNP2 could have an effect on the peri-tumor environment, obviously restraining the growth progress of gliomas, and eventually improving cognitive levels in C6-bearing rats.Peer reviewedProo