Investigations of electron emission characteristics of low work function surfaces Quarterly report no. 5, 1 Oct. - 31 Dec. 1965

Electron emission characteristics of low work function surfaces from magnetic deflection probe measurements of cesium adsorption on tungste

Investigations of electron emission characteristics of low work function surfaces Quarterly report, 28 Sep. - 27 Dec. 1966

Coadsorption of cesium and fluorine on tungsten, and analysis of mechanisms leading to decay of field emission current from low work function zirconium/oxygen coated tungsten emitte

Investigations of electron emission characteristics of low work function surfaces Quarterly report no. 2, 1 Jan. - 31 Mar. 1966

Formation and electron emission characteristics of low work function surface

Investigations of electron emission characteristics of low work function surfaces Final report, 27 Sep. 1964 - 28 Sep. 1966

Electron emission characteristics of low work function surface

Investigations of electron emission characteristics of low work function surfaces Final report, 28 Sep. 1966 - 13 Nov. 1967

Electron emission characteristics of low work function surface

Volume 2 - Literature review of adsorption on metal surfaces Final report, 1 May 1966 - 2 Jul. 1967

Atom and ion desorption energy, chemisorption theory and surface bonds, work functions and potential energy in literature review of adsorption on metal surface

Bench-to-bedside review : targeting antioxidants to mitochondria in sepsis

Peer reviewedPublisher PD

The Analyst’s Hierarchy of Needs: Grounded Design Principles for Tailored Intelligence Analysis Tools

Intelligence analysis involves gathering, analyzing, and interpreting vast amounts of information from diverse sources to generate accurate and timely insights. Tailored tools hold great promise in providing individualized support, enhancing efficiency, and facilitating the identification of crucial intelligence gaps and trends where traditional tools fail. The effectiveness of tailored tools depends on an analyst’s unique needs and motivations, as well as the broader context in which they operate. This paper describes a series of focus discovery exercises that revealed a distinct hierarchy of needs for intelligence analysts. This reflection on the balance between competing needs is of particular value in the context of intelligence analysis, where the compartmentalization required for security can make it difficult to group design patterns in stakeholder values. We hope that this study will enable the development of more effective tools, supporting the well-being and performance of intelligence analysts as well as the organizations they serve

Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells

Abstract Background Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased approach to identify pathways activated in bronchoalveolar lavage (BAL) cells can shed light on the pathogenesis of this complex disease. Methods We recruited 15 patients with various stages of sarcoidosis and 12 healthy controls. All subjects underwent bronchoscopy with lavage. For each subject, total RNA was extracted from BAL cells and hybridized to an Affymetrix U133A microarray. Rigorous statistical methods were applied to identify differential gene expression between subjects with sarcoidosis vs. controls. To better elucidate pathways differentially activated between these groups, we integrated network and gene set enrichment analyses of BAL cell transcriptional profiles. Results Sarcoidosis patients were either non-smokers or former smokers, all had lung involvement and only two were on systemic prednisone. Healthy controls were all non-smokers. Comparison of BAL cell gene expression between sarcoidosis and healthy subjects revealed over 1500 differentially expressed genes. Several previously described immune mediators, such as interferon gamma, were upregulated in the sarcoidosis subjects. Using an integrative computational approach we constructed a modular network of over 80 gene sets that were highly enriched in patients with sarcoidosis. Many of these pathways mapped to inflammatory and immune-related processes including adaptive immunity, T-cell signaling, graft vs. host disease, interleukin 12, 23 and 17 signaling. Additionally, we uncovered a close association between the proteasome machinery and adaptive immunity, highlighting a potentially important and targetable relationship in the pathobiology of sarcoidosis. Conclusions BAL cells in sarcoidosis are characterized by enrichment of distinct transcriptional programs involved in immunity and proteasomal processes. Our findings add to the growing evidence implicating alveolar resident immune effector cells in the pathogenesis of sarcoidosis and identify specific pathways whose activation may modulate disease progression