GIS and GPS Emergency Response Lessons Learned from the Space Shuttle Columbia Disaster

In the wake of the Space Shuttle Columbia disaster, several key lessons were learned about large-scale, multi-agency disaster response as it pertains to Geographic Information Systems (GIS) and the Global Positioning System (GPS). This article discusses those lessons and reveals Extension education opportunities that can greatly streamline local interagency and intragency emergency response/homeland security efforts

GIS and GPS Emergency Response Lessons Learned from the Space Shuttle Columbia Disaster

In the wake of the Space Shuttle Columbia disaster, several key lessons were learned about large-scale, multi-agency disaster response as it pertains to Geographic Information Systems (GIS) and the Global Positioning System (GPS). This article discusses those lessons and reveals Extension education opportunities that can greatly streamline local interagency and intragency emergency response/homeland security efforts

Predicting the onset of major depressive disorder and dysthymia in older adults with subthreshold depression: a community based study

 16) but no DSM mood disorder from a longitudinal study among a large population based cohort aged between 55 and 85 years in The Netherlands. Of these subjects, 31 (20.1%) developed a mood disorder (major depression and/or dysthymia) at three-year or six-year follow-up. We examined risk factors and individual symptoms of mood disorder as predictors of onset of mood disorder. Results Two variables were found to be significant predictors in both bivariate and multivariate analyses: eating problems and sleep problems. The incidence of mood disorders differed strongly for different subpopulations, varying from 9% (for those not having any of the two risk factors) to 57% (for those having both risk factors). Conclusions It appears to be possible to predict to a certain degree whether a subject with subthreshold depression will develop a mood disorder during the following years

On the theory of Chemical Combination

This reproduction and digital scan of Crum Brown's MD thesis of 1861 was produced by Andrew J. Alexander. More information on the life and works of Alexander Crum Brown can be found online at http://homepages.ed.ac.uk/aa01/crum/crum_index.htmlThis paper was presented in 1861 to the Faculty of Medicine, when I was a candidate for the degree of M.D. In consequence of a somewhat adverse opinion expressed as to the speculations contained in it, I exercised the discretion allowed (I think unwisely) by the University to graduates, and did not print it. Some of my friends have urged me to do so now, and although I am quite aware that it contains much that is crude and some things that are erroneous, and that all that was then new or important in it has since been much better expressed by others, I still think that it is not altogether unworthy of preservation as a contribution to the history of the subject. It is printed verbatim, and I would ask such of my friends as may read it to recollect that it was written eighteen years ago by a medical student. A. C. B. UNIVERSITY OF EDINBURGH, March 1879

Storing the wisdom: chemical concepts and chemoinformatics

The purpose of the paper is to examine the nature of chemical concepts, and the ways in which they are applied in chemoinformatics systems. An account of concepts in philosophy and in the information sciences leads to an analysis of chemical concepts, and their representation. The way in which concepts are applied in systems for information retrieval and for structure–property correlation are reviewed, and some issues noted. Attention is focused on the basic concepts or substance, reaction and property, on the organising concepts of chemical structure, structural similarity, periodicity, and on more specific concepts, including two- and three-dimensional structural patterns, reaction types, and property concepts. It is concluded that chemical concepts, despite (or perhaps because of) their vague and mutable nature, have considerable and continuing value in chemoinformatics, and that an increased formal treatment of concepts may have value in the future

A point mutation in cpsE renders Streptococcus pneumoniae nonencapsulated and enhances its growth, adherence and competence.

BACKGROUND: The polysaccharide capsule is a major virulence factor of the important human pathogen Streptococcus pneumoniae. However, S. pneumoniae strains lacking capsule do occur. RESULTS: Here, we report a nasopharyngeal isolate of Streptococcus pneumoniae composed of a mixture of two phenotypes; one encapsulated (serotype 18C) and the other nonencapsulated, determined by serotyping, electron microscopy and fluorescence isothiocyanate dextran exclusion assay.By whole genome sequencing, we demonstrated that the phenotypes differ by a single nucleotide base pair in capsular gene cpsE (C to G change at gene position 1135) predicted to result in amino acid change from arginine to glycine at position 379, located in the cytoplasmic, enzymatically active, region of this transmembrane protein. This SNP is responsible for loss of capsule production as the phenotype is transferred with the capsule operon. The nonencapsulated variant is superior in growth in vitro and is also 117-fold more adherent to and more invasive into Detroit 562 human epithelial cells than the encapsulated variant.Expression of six competence pathway genes and one competence-associated gene was 11 to 34-fold higher in the nonencapsulated variant than the encapsulated and transformation frequency was 3.7-fold greater. CONCLUSIONS: We identified a new single point mutation in capsule gene cpsE of a clinical S. pneumoniae serotype 18C isolate sufficient to cause loss of capsule expression resulting in the co-existence of the encapsulated and nonencapsulated phenotype. The mutation caused phenotypic changes in growth, adherence to epithelial cells and transformability. Mutation in capsule gene cpsE may be a way for S. pneumoniae to lose its capsule and increase its colonization potential

Medicine Plus Mindset: A Mixed-Methods Evaluation of a Novel Mindset-Focused Training for Primary Care Teams

Objectives Patient mindsets influence health outcomes; yet trainings focused on care teams’ understanding, recognizing, and shaping patient mindsets do not exist. This paper aims to describe and evaluate initial reception of the “Medicine Plus Mindset” training program. Methods Clinicians and staff at five primary care clinics (N = 186) in the San Francisco Bay Area received the Medicine Plus Mindset Training. The Medicine Plus Mindset training consists of a two-hour training program plus a one-hour follow-up session including: (a) evidence to help care teams understand patients’ mindsets’ influence on treatment; (b) a framework to support care teams in identifying specific patient mindsets; and (c) strategies to shape patient mindsets. Results We used a common model (Kirkpatrick) to evaluate the training based on participants’ reaction, learnings, and behavior. Reaction: Participants rated the training as highly useful and enjoyable. Learnings: The training increased the perceived importance of mindsets in healthcare and improved self-reported efficacy of using mindsets in practice. Behavior: The training increased reported frequency of shaping patient mindsets. Conclusions Development of this training and the study’s results introduce a promising and feasible approach for integrating mindset into clinical practice. Practice Implications Mindset training can add a valuable dimension to clinical care and should be integrated into training and clinical practice

Ovarian cancer

Ovarian cancer is not a single disease and can be subdivided into at least five different histological subtypes that have different identifiable risk factors, cells of origin, molecular compositions, clinical features and treatments. Ovarian cancer is a global problem, is typically diagnosed at a late stage and has no effective screening strategy. Standard treatments for newly diagnosed cancer consist of cytoreductive surgery and platinum-based chemotherapy. In recurrent cancer, chemotherapy, anti-angiogenic agents and poly(ADP-ribose) polymerase inhibitors are used, and immunological therapies are currently being tested. High-grade serous carcinoma (HGSC) is the most commonly diagnosed form of ovarian cancer and at diagnosis is typically very responsive to platinum-based chemotherapy. However, in addition to the other histologies, HGSCs frequently relapse and become increasingly resistant to chemotherapy. Consequently, understanding the mechanisms underlying platinum resistance and finding ways to overcome them are active areas of study in ovarian cancer. Substantial progress has been made in identifying genes that are associated with a high risk of ovarian cancer (such as BRCA1 and BRCA2), as well as a precursor lesion of HGSC called serous tubal intraepithelial carcinoma, which holds promise for identifying individuals at high risk of developing the disease and for developing prevention strategies

Prospectus, November 4, 1975

PC NEWS IN BRIEF: VETERAN, DID YOU KNOW?, CONCERT, X-COUNTRY NATIONALS; New road opens; FB team may bring fee increase; $50,000 in books missing; editorials; Letters To The Editor; Roots & Radicals; Committee to form; A Statement of Advertising Policy; Committee to form; ISSC Award Program Changes; Alice didn\u27t... on Wed.; Debate Team begins season; Play cast chosen; Distaff Side; Good News; Black Dance Presented; Speech Team Wins S.I.C.C.M. Tourey; New 3-Hour Course: Death and the Dying; Adult Diversion program; Champs are IM champs; Coach\u27s Corner; Basketball tryouts; Mudrock fires 170 at state golf meet; Sports Views; Burk resigns; Fast Freddy Winners; Fast Freddy\u27s football forecast; Let\u27s hear it for the Parkland Whatevers; PC women netters Spike Danville JC; Games Of November 8; The little old watchmaker at work in the space age; Dear Bonnie; PC News in brief Sign up for tourneys; College Representatives; Congratulations; Bonnie Raitt Plays; Vinyl Love; Country Bouquet; Kottke picks U of I; Foto-Funny\u27s; Reverse Discrimination?; 200 Years of navy; Classified; Club Notes: SNA meets..., Electronics Association; Far Out Planet; Skylines; Parkland Eventshttps://spark.parkland.edu/prospectus_1975/1003/thumbnail.jp