Causal inference with multi-state models - estimands and estimators of the population-attributable fraction

The population-attributable fraction (PAF) is a popular epidemiological measure for the burden of a harmful exposure within a population. It is often interpreted causally as proportion of preventable cases after an elimination of exposure. Originally, the PAF has been defined for cohort studies of fixed length with a baseline exposure or cross-sectional studies. An extension of the definition to complex time-to-event data is not straightforward. We revise the proposed approaches in literature and provide a clear concept of the PAF for these data situations. The conceptualization is achieved by a proper differentiation between estimands and estimators as well as causal effect measures and measures of association.Comment: A revised version of this manuscript has been submitted to a journal on March 8 201

Observation of Lasing Mediated by Collective Atomic Recoil

We observe the buildup of a frequency-shifted reverse light field in a unidirectionally pumped high-$Q$ optical ring cavity serving as a dipole trap for cold atoms. This effect is enhanced and a steady state is reached, if via an optical molasses an additional friction force is applied to the atoms. We observe the displacement of the atoms accelerated by momentum transfer in the backscattering process and interpret our observations in terms of the collective atomic recoil laser. Numerical simulations are in good agreement with the experimental results.Comment: 4 pages, 3 figure

Phase-sensitive detection of Bragg scattering at 1D optical lattices

We report on the observation of Bragg scattering at 1D atomic lattices. Cold atoms are confined by optical dipole forces at the antinodes of a standing wave generated by the two counter-propagating modes of a laser-driven high-finesse ring cavity. By heterodyning the Bragg-scattered light with a reference beam, we obtain detailed information on phase shifts imparted by the Bragg scattering process. Being deep in the Lamb-Dicke regime, the scattered light is not broadened by the motion of individual atoms. In contrast, we have detected signatures of global translatory motion of the atomic grating.Comment: 4 pages, 4 figure

Self-synchronization and dissipation-induced threshold in collective atomic recoil lasing

Networks of globally coupled oscillators exhibit phase transitions from incoherent to coherent states. Atoms interacting with the counterpropagating modes of a unidirectionally pumped high-finesse ring cavity form such a globally coupled network. The coupling mechanism is provided by collective atomic recoil lasing, i.e., cooperative Bragg scattering of laser light at an atomic density grating, which is self-induced by the laser light. Under the rule of an additional friction force, the atomic ensemble is expected to undergo a phase transition to a state of synchronized atomic motion. We present the experimental investigation of this phase transition by studying the threshold behavior of this lasing process

Multiple Reflections and Diffuse Scattering in Bragg Scattering at Optical Lattices

We study Bragg scattering at 1D atomic lattices. Cold atoms are confined by optical dipole forces at the antinodes of a standing wave generated inside a laser-driven cavity. The atoms arrange themselves into an array of lens-shaped layers located at the antinodes of the standing wave. Light incident on this array at a well-defined angle is partially Bragg-reflected. We measure reflectivities as high as 30%. In contrast to a previous experiment devoted to the thin grating limit [S. Slama, et al., Phys. Rev. Lett. 94, 193901 (2005)] we now investigate the thick grating limit characterized by multiple reflections of the light beam between the atomic layers. In principle multiple reflections give rise to a photonic stop band, which manifests itself in the Bragg diffraction spectra as asymmetries and minima due to destructive interference between different reflection paths. We show that close to resonance however disorder favors diffuse scattering, hinders coherent multiple scattering and impedes the characteristic suppression of spontaneous emission inside a photonic band gap

The population-attributable fraction for time-dependent exposures using dynamic prediction and landmarking

The public health impact of a harmful exposure can be quantified by the population-attributable fraction (PAF). The PAF describes the attributable risk due to an exposure and is often interpreted as the proportion of preventable cases if the exposure could be extinct. Difficulties in the definition and interpretation of the PAF arise when the exposure of interest depends on time. Then, the definition of exposed and unexposed individuals is not straightforward. We propose dynamic prediction and landmarking to define and estimate a PAF in this data situation. Two estimands are discussed which are based on two hypothetical interventions that could prevent the exposure in different ways. Considering the first estimand, at each landmark the estimation problem is reduced to a time-independent setting. Then, estimation is simply performed by using a generalized-linear model accounting for the current exposure state and further (time-varying) covariates. The second estimand is based on counterfactual outcomes, estimation can be performed using pseudo-values or inverse-probability weights. The approach is explored in a simulation study and applied on two data examples. First, we study a large French database of intensive care unit patients to estimate the population-benefit of a pathogen-specific intervention that could prevent ventilator-associated pneumonia caused by the pathogen Pseudomonas aeruginosa. Moreover, we quantify the population-attributable burden of locoregional and distant recurrence in breast cancer patients.Comment: A revised version has been submitte

The population-attributable fraction for time-dependent exposures and competing risks - A discussion on estimands

The population-attributable fraction (PAF) quantifies the public health impact of a harmful exposure. Despite being a measure of significant importance an estimand accommodating complicated time-to-event data is not clearly defined. We discuss current estimands of the PAF used to quantify the public health impact of an internal time-dependent exposure for data subject to competing outcomes. To overcome some limitations, we proposed a novel estimand which is based on dynamic prediction by landmarking. In a profound simulation study, we discuss interpretation and performance of the various estimands and their estimators. The methods are applied to a large French database to estimate the health impact of ventilator-associated pneumonia for patients in intensive care.Comment: A revision has been submitte

Massive Dirac fermions in a ferromagnetic kagome metal

The kagome lattice is a two-dimensional network of corner-sharing triangles known as a platform for exotic quantum magnetic states. Theoretical work has predicted that the kagome lattice may also host Dirac electronic states that could lead to topological and Chern insulating phases, but these have evaded experimental detection to date. Here we study the d-electron kagome metal Fe$_3$Sn$_2$ designed to support bulk massive Dirac fermions in the presence of ferromagnetic order. We observe a temperature independent intrinsic anomalous Hall conductivity persisting above room temperature suggestive of prominent Berry curvature from the time-reversal breaking electronic bands of the kagome plane. Using angle-resolved photoemission, we discover a pair of quasi-2D Dirac cones near the Fermi level with a 30 meV mass gap that accounts for the Berry curvature-induced Hall conductivity. We show this behavior is a consequence of the underlying symmetry properties of the bilayer kagome lattice in the ferromagnetic state with atomic spin-orbit coupling. This report provides the first evidence for a ferromagnetic kagome metal and an example of emergent topological electronic properties in a correlated electron system. This offers insight into recent discoveries of exotic electronic behavior in kagome lattice antiferromagnets and may provide a stepping stone toward lattice model realizations of fractional topological quantum states.Comment: 19 pages, 4 figure

Dimensional Crossover in Bragg Scattering from an Optical Lattice

We study Bragg scattering at 1D optical lattices. Cold atoms are confined by the optical dipole force at the antinodes of a standing wave generated inside a laser-driven high-finesse cavity. The atoms arrange themselves into a chain of pancake-shaped layers located at the antinodes of the standing wave. Laser light incident on this chain is partially Bragg-reflected. We observe an angular dependence of this Bragg reflection which is different to what is known from crystalline solids. In solids the scattering layers can be taken to be infinitely spread (3D limit). This is not generally true for an optical lattice consistent of a 1D linear chain of point-like scattering sites. By an explicit structure factor calculation we derive a generalized Bragg condition, which is valid in the intermediate regime. This enables us to determine the aspect ratio of the atomic lattice from the angular dependance of the Bragg scattered light.Comment: 4 pages, 5 figure

Creating and probing long-range order in atomic clouds

Ultracold atoms interacting with the optical modes of a high-Q optical ring cavity can synchronize their motion. The collective behavior makes the system interesting for quantum computing applications. This paper is devoted to the study of the collective coupling. We report on the first observation of a collective dynamics and on the realization of a laser, the gain mechanism of which is based on collective atomic recoil. We show that, if the atoms are subject to a friction force, starting from an unordered distribution they spontaneously form a moving density grating. Furthermore, we demonstrate that a 1D atomic density grating can be probed via Bragg scattering. By heterodyning the Bragg-reflected light with a reference beam, we obtain detailed information on phase shifts induced by the Bragg scattering process