Split of Composite Components for Distributed Applications

International audienceComposite structures as in UML are a way to ease the development of complex applications. Composite classes contain sub-components that are instantiated, interconnected and configured along with the composite. Composites may also contain operations and further attributes. Their deployment on distributed platforms is not trivial, since their sub-components might be allocated to different computing nodes. In this case, the deployment implies a split of the composite. In this paper, we will motivate why composites need to be allocated to different nodes in some cases by examining the particular case of interaction components. We will also discuss several options to achieve the separation and their advantages and disadvantages including modeling restrictions for the classes

Automated and traceable processing for large-scale high-throughput sequencing facilities

Scaling up production in medium and large high-throughput sequencing facilities presents a number of challenges. As the rate of samples to process increases, manually performing and tracking the center’s operations becomes increasingly difficult, costly and error prone, while processing the massive amounts of data poses significant computational challenges. We present our ongoing work to automate and track all data-related procedures at the CRS4 Sequencing and Genotyping Platform, while integrating state-of-the-art processing technologies such as Hadoop, OMERO, iRODS, and Galaxy into our automated workflows. Currently, the core system is in its testing phase and it is on schedule to be in production use at CRS4 by May 2013. The results thus far obtained are encouraging and the authors are confident that the CRS4 Platform will increase its efficiency and capacity thanks to this system. In the near future, the integration components will be released as as open source software.23-24Pubblicat

Natural radioactivity in Sardinian granite dimension stones

http://www.fe.infn.it/u/mantovani/CV/Proceedings/Puccini_10b.pd

Employment of portable gamma-ray spectrometer in survey and mapping of intrusive complexes: a case study from the Buddusò pluton (Sardinia)

http://www.fe.infn.it/u/mantovani/CV/Proceedings/Puccini_10a.pd

Toward an Accurate and Fast Hybrid Multi-Simulation with the FMI-CS Standard

International audienceMulti-simulation in the context of future smart electrical grids consists in associating components modeling different physical domains, but also their local or global control. Our DACCOSIM multi-simulation environment is based on the version 2.0 of the FMI-CS (Functional Mock-up Interface for Co-Simulation) standard maintained by the Modelica Association. It has been specifically designed to run large-scale and complex systems on a single PC or a cluster of multicore nodes. But it is quite challenging to accurately simulate FMUs-composed systems involving predictable and unpredictable events while preserving the system overall performance. This paper presents some additions to the FMI-CS standard aiming to improve the accuracy and the performance of distributed multi-simulations involving a mix of both time steps and various kinds of events. The proposed FMI-CS primitives are explained, as well as the Master Algorithm strategies to exploit them efficiently

Early Eighteenth Century Conceptions of the Sublime

In this thesis, I aim to identify and discuss the philosophical conception of the sublime that arises out of the important and influential early eighteenth century discussion in English of the ancient Greek rhetorical text Longinus’s Peri Hypsous (third century, usually translated in English as On the Sublime). To do so, I challenge the historians of aesthetics’ conventional approach that aims to identify and isolate the aesthetic as a distinct, autonomous kind in pre-aesthetic accounts of concepts now claimed by the field of aesthetics. Against the historians of aesthetics’ existing picture that deems the earliest English discussion of the sublime in poetry by John Dennis and the so called Longinian Tradition to be only concerned with the rhetorical sublime style, I argue that they actually introduce the discussion of the philosophically relevant sublime, which by way of identification will be referred to as the philosophical sublime. Also against the historians of aesthetics’ existing picture that attributes the Third Earl of Shaftesbury with the first account of aesthetic concept of the sublime as a distinct experience of nature, that is, the philosophically narrow natural sublime, I argue that Shaftesbury’s philosophical sublime has broader philosophical implications and a more nuanced relationship with the Longinian Tradition. Employing my history of philosophy approach to these accounts, I reveal that Dennis and Shaftesbury both similarly describe the philosophical sublime as a harmonious state of the human soul that when attained by the sublime genius is the perfection of human nature; that is, the height of human beauty, virtue, and knowledge. Further, on both of their accounts this sublime state of harmony is a form of direct experience of God’s divine nature. By looking at Alexander Pope’s satirical response to their discussion, I further argue that, although these accounts are deeply concerned with coming to know the true sublime and avoiding the false sublime, ultimately, they fail to reach the certainty that they aspire to. Thus, I offer a richer and more philosophically sophisticated view of the early eighteenth century discussion of the philosophical sublime

Glial cell line-derived neurotrophic factor influences proliferation of osteoblastic cells

Little is known about the role of neurotrophic growth factors in bone metabolism. This study investigated the short-term effects of glial cell line-derived neurotrophic factor (GDNF) on calvarial-derived MC3T3-E1 osteoblasts. MC3T3-E1 expressed GDNF as well as its canonical receptors, GFRα1 and RET. Addition of recombinant GDNF to cultures in serum-containing medium modestly inhibited cell growth at high concentrations; however, under serum-free culture conditions GDNF dose-dependently increased cell proliferation. GDNF effects on cell growth were inversely correlated with its effect on alkaline phosphatase (ALP) activity showing a significant dose-dependent inhibition of relative ALP activity with increasing concentrations of GDNF in serum-free culture medium. Live/dead and lactate dehydrogenase assays demonstrated GDNF did not significantly affect cell death or survival under serum-containing and serum-free conditions. The effect of GDNF on cell growth was abolished in the presence of inhibitors to GFR α 1 and RET indicating that GDNF stimulated calvarial osteoblasts via its canonical receptors. Finally, this study found that GDNF synergistically increased tumor necrosis factor-α (TNF-α)-stimulated MC3T3-E1 cell growth suggesting that GDNF interacted with TNF-α-induced signaling in osteoblastic cells. In conclusion, this study provides evidence for a direct, receptor-mediated effect of GDNF on osteoblasts highlighting a novel role for GDNF in bone physiology. \ud \u

Gaspard2 UML profile documentation

This document describes the current UML profile of Gaspard2. This profile extends the UML semantics to allow the user to describe a SoC (System-on-Chip) in three steps: the application (behavior of the Soc), the hardware architecture, and the association of the application to the hardware architecture. The application is represented following a data flow model, but additional mechanisms permit the usage of control flow on those applications. In addition to those notions, the profile contains a package introducing factorization mechanisms to enable the compact description of massively parallel and repetitive systems