Gerakan Madres De La Plaza De Mayo dan Dampaknya terhadap Penegakan HAM di Argentina

This research aims to understanding and explaining the strategy used by Madres De La Plaza de Mayo Movement to establishing human rights enforcement in Argentina as well as Understanding and explaining the impact of the efforts undertaken by the Madres De La Plaza de Mayo Movement towards human rights establishment in Agentina. For that, in achieving the objectives, the writer uses descriptive analytic method. The data collection techniques used is aliterature review. To process and analyze the data, the authors use qualitative analysis techniques and to discuss and explain the results of the analysis, the authors use inductive-deductive writing technique. The results obtained from this study indicate that the Madres De La Plaza de Mayo is a movement that arose as a result of human rights violations committed by the military regime in Argentina in 1976-1983. This movement then taking action in protest and demanded the Argentine government to enforce human rights in Argentina. In conducting the efforts, the movement was able to build a network and cooperation with foreign actors either NGO, IGO and other countries for support and simultaneously pressed the Argentine government in relations to defending human rights voiced by this movement. This strategy then have a positive impact in encouraging the emergence of democracy in Argentina and broadly encourage the emergence of a series of policies and measures in the various aspects of human rights in Argentina

A Novel Implantable Glaucoma Valve Using Ferrofluid

Purpose To present a novel design of an implantable glaucoma valve based on ferrofluidic nanoparticles and to compare it with a well-established FDA approved valve. Setting: Massachusetts Eye & Ear Infirmary, Boston, USA. Methods: A glaucoma valve was designed using soft lithography techniques utilizing a water-immiscible magnetic fluid (ferrofluid) as a pressure-sensitive barrier to aqueous flow. Two rare earth micro magnets were used to calibrate the opening and closing pressure. In-vitro flow measurements were performed to characterize the valve and to compare it to Ahmed™ glaucoma valve. The reliability and predictability of the new valve was verified by pressure/flow measurements over a period of three months and X-ray diffraction (XRD) analysis over a period of eight weeks. In vivo assessment was performed in three rabbits. Results: In the in vitro experiments, the opening and closing pressures of the valve were 10 and 7 mmHg, respectively. The measured flow/pressure response was linearly proportional and reproducible over a period of three months (1.8 µl/min at 12 mmHg; 4.3 µl/min at 16 mmHg; 7.6 µl/min at 21 mmHg). X-ray diffraction analysis did not show oxidization of the ferrofluid when exposed to water or air. Preliminary in vivo results suggest that the valve is biocompatible and can control the intraocular pressure in rabbits. Conclusions: The proposed valve utilizes ferrofluid as passive, tunable constriction element to provide highly predictable opening and closing pressures while maintaining ocular tone. The ferrofluid maintained its magnetic properties in the aqueous environment and provided linear flow to pressure response. Our in-vitro tests showed reliable and reproducible results over a study period of three months. Preliminary in-vivo results were very promising and currently more thorough investigation of this device is underway

The blind spots of secularization

According to several international surveys Spain is among the western countries with the most negative views of Jews. While quantitative data on the topic accumulates, there is a significant lack of interpretative approaches that might explain the particular Spanish case. This paper presents the background, methodology and major results of a discussion group-based study on antisemitism, which was conducted in Spain in the autumn of 2009. The study identifies and locates in different socio-economic and ideological milieus the range of stereotypical discourses on Jews, Judaism and the Arab–Israeli conflict in Spain. Analysis of the group meetings shows that, despite growing secularization in Spanish society, the central explanatory variable for persisting and resurging antisemitism in this country is still religion in a broad cultural sense.Peer reviewe

MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles

Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by oligodendrocytes and microRNAs have been postulated as a promising tool to induce oligodendrocyte precursor cell differentiation and therefore remyelination. Herein, DSPC liposomes and PLGA nanoparticles were studied for miR-219a-5p encapsulation, release and remyelination promotion. In parallel, they were compared with biologically engineered extracellular vesicles overexpressing miR-219a-5p. Interestingly, extracellular vesicles showed the highest oligodendrocyte precursor cell differentiation levels and were more effective than liposomes and polymeric nanoparticles crossing the blood–brain barrier. Finally, extracellular vesicles were able to improve EAE animal model clinical evolution. Our results indicate that the use of extracellular vesicles as miR-219a-5p delivery system can be a feasible and promising strategy to induce remyelination in multiple sclerosis patients.This work was supported by Carlos III Institute, (PI17/00189 and DTS15/00069), by Fondo Europeo de Desarrollo Regional—FEDER, by the Gipuzkoa Regional Council (DFG 15/006), by grant from the Basque Government (RIS3/DTS/2018222025), by the Department of Industry of the Basque Country (ELKARTEK 16/014), and the Spanish State Research Agency (SAF2017-87670-R) and Maria de Maeztu Units of Excellence Program Grant MDM-2017-0720). I.O.-Q., A.A. and L.I. were supported by the Department of Education of the Basque Government. IOQ and LAN were supported by EMBO short Term Fellowship Programme. LAN was supported by a Canadian graduate scholarship from the Canadian Institutes of Health Research (CGS-D CIHR).PRC was supported by Ikerbasque, the Basque Foundation for Science

Problems in using experimental data for dynamic substructuring of a lumped parameter system

In experimental dynamic substructuring two main problems are defined: addition of substructures (coupling) and subtraction of substructures (decoupling). Decoupling can be important in built-up structures where some components (critical subsystems or joints) cannot be removed or accessed easily. Whilst addition of substructures often leads to satisfactory results even in relatively complex cases, subtraction of substructures is a source of problems even in apparently trivial applications. Some critical issues of decoupling (such as ill-conditioning around a discrete number of frequencies) have been highlighted and verified by using simulated data corrupted by random noise. In this paper, experimental data acquired on a lumped parameter benchmark system are used to check previously highlighted problems both in coupling and decoupling, and to look for additional issues (systematic errors, inconsistencies, etc.) that can not be observed from simulated data

Damage diagnostic technique combining machine learning approach with a sensor swarm

A Model-free approach is particularly valuable for Structural Health Monitoring because real structures are often too complex to be modelled accurately, requiring anyhow a large quantity of sensor data to be processed. In this context, this paper presents a machine learning technique that analyses data acquired by swarm of a sensor. The proposed algorithm uses unsupervised learning and is based on the use principal component analysis and symbolic data analysis: PCA extracts features from the acquired data and use them as a template for clustering. The algorithm is tested with numerical experiments. A truss bridge is modelled by a finite element model, and structural response is produced in healthy and several damaged scenarios. The present research shows also the importance of considering a sufficient number of measurements points along the structure, i.e. the swarm of sensors. This technology, which nowadays is easily attainable with the application of optical Fiber Bragg Grating strain sensors. The difficulties related to the early stage damage detection in complex structures can be skipped, especially when ambient, narrow band, moving loads are considered, enhancing the prediction capabilities of the proposed algorithm

Damping control of polodes, inertia and natural frequencies: Theory and application to automotive suspensions

This paper shows how tunable dampers can help control the instant centre of rotation of a 2D rigid body and its polode in planar motion, which in turn implies that the inertia tensor can also be controlled. For mechanisms equipped with some elasticity the results show that damping can also control their natural frequencies. The foundation of a general theory to control the polode is presented, exploring the chance of an optimal control formulation of the problem via a variational control principle, approached by the LQR (Linear Quadratic Regulator) method, after a suitable linearization. Application to automotive suspension linkages is presented that demonstrates the control of the instant roll centre and axis and consequently its instant roll vibration frequency to optimize the response, when excited by lateral inertia forces

OPTYRE—Real time estimation of rolling resistance for intelligent tyres

The study of the rolling tyre is a problem framed in the general context of nonlinear elasticity. The dynamics of the related phenomena is still an open topic, even though few examples and models of tyres can be found in the technical literature. The interest in the dissipation effects associated with the rolling motion is justified by their importance in fuel-saving and in the context of an eco-friendly design. However, a general lack of knowledge characterizes the phenomenon, since not even direct experience on the rolling tyre can reveal the insights of the correlated different dissipation effects, as the friction between the rubber and the road, the contact kinematics and dynamics, the tyre hysteretic behaviour and the grip. A new technology, based on fibre Bragg grating strain sensors and conceived within the OPTYRE project, is illustrated for the specific investigation of the tyre dissipation related phenomena. The remarkable power of this wireless optical system stands in the chance of directly accessing the behaviour of the inner tyre in terms of stresses when a real-condition-rolling is experimentally observed. The ad hoc developed tyre model has allowed the identification of the instant grip conditions, of the area of the contact patch and allows the estimation of the instant dissipated power, which is the focus of this paper

Application of DOE to estimate the variability of SEA solution

Statistical Energy Analysis (SEA) is the most acknowledged method to predict the averaged sound and vibration levels in mechanical systems in the high frequency range. A limit of this analysis is that of providing only the mean value of the variables of interest. The mean value provided by SEA equations is the mean of the responses of a set of similar systems, averaged on frequency bands. Two systems are considered similar if their physical parameters are slightly different. No information on the standard deviation is obtained by SEA as it would be expected by a true statistical approach. In this paper, the variability of SEA parameters (coupling loss factors, internal loss factor and injected powers) to uncertainties in the physical properties of the considered mechanical system (Young modulus, material density, geometry, ...) is investigated using a Design of Experiment (DoE) approach. This is done in order to take into account the idea of similar systems. Subsequently, the variability of SEA solution to the uncertainties on SEA parameters found at the previous step is investigated by using again a DoE approach