Towards a cost-effectiveness analysis of the measurement of biodiversity indicators

A comprehensive quantification of biodiversity in farming systems would require a very significant amount of work (and funds) even for a small area. Therefore, biodiversity indicators are needed to solve the problem of the measurement feasibility. Even though the issue of cost and effectiveness is central for the evaluation of the indicators, only the latter is discussed in detail in the scientific literature. This work presents a cost analysis based on the direct gathering of records from a farm-scale biodiversity survey (EU-FP7, BioBio - “Indicators for biodiversity in organic and low-input farming systems”) where the analysis of costs is part of the project. It is a simple method for comparing different indicators by their ratio of cost/effectiveness. Here we present the results from the French case study (Gascony Hills, Midi-Pyrenees Region).biodiversity, cost-effectiveness, indicator costs, Agricultural and Food Policy, Q2,

A comparative cost-effectiveness analysis of biodiversity indicators in grassland farming systems

Farm Management, Resource /Energy Economics and Policy,

Identifying research priorities for the competitiveness of arable crops

EU agriculture and arable crops in particular are suffering from competitiveness deficits compared to other producers in the world economy. One potential strategy to cope with competitiveness challenges is to focus on research and technological innovation. The objective of this paper is to present the results of the project EUROCROP (Agricultural research for improving arable crop competitiveness – EUROCROP - http://www.eurocrop.cetiom.fr/), aimed at the identification of research priorities for arable crop competitiveness. The project adopts a definition of competitiveness based on a combination of economic competitiveness and social/environmental sustainability. Furthermore, the project utilises both a crop chain and a horizontal issue perspective, and develops research priorities through the interaction of the scientific level (expert group approach) and the stakeholder level (scenario analysis). The main result of the project is the elaboration of approximately eighty research topics. Among these, the main areas for research identified are A: Risk management and adaptation of arable farming; B: Innovation in cropping systems for high environmental and economic performances; C: Limiting the impact of arable crop cropping systems on green-house gas emissions; D: Better understanding of public concern about arable crop production and products and communication with global and local societies. The project confirms that a number of well established research topics retain their importance (e.g. yield improvement, plant protection). However, they require cautious coordination with an increasingly complex system of short term priorities.Arable crops, crop chain, competitiveness, research priorities, foresight, Agricultural and Food Policy,

At Home in the World?: The Ornamental Life of Sailors in Victorian Sailortown

This article explores the representation of British sailortown and merchant sailors onshore in the context of their representation in Victorian writing and contemporary journalism. It proposes that sailortown functioned as an urban setting which offered the traveling or returning sailor an important sense of homeliness—a homeliness that was paradoxically based on the promotion of a collective and worldly belonging. This sense of “worldliness” was articulated through aspects of ornamental material culture ranging from sailortown's visual display of nautical and transnational symbols, to the interior arrangements of places of hospitality such as Sailors’ Homes, to sailors’ own forms of portable property. By thinking more closely about the relationship between the domestic and the global in the context of maritime culture, the article proposes that the ornamental features of the seafarer's life, in all its diverse manifestations, serves to reveal the paradoxes and rich ambivalences that underscore the situation of the nineteenth-century sailor onshore

Cost Assessment of the Field Measurement of Biodiversity: a Farm-scale Case Study

Attention to the effects of agriculture on biodiversity is currently increasing. Yet the measurement of biodiversity is both time-consuming and costly. Considering the limited budgets available for biodiversity conservation, it is timely to focus on the cost analysis of biodiversity indicators in order to ensure the optimization of the scarce funds available. We present the cost analysis of operational data from the fieldwork efforts undertaken in the measurement of biodiversity indicators at farm-scale. Methodological issues are discussed

Towards a cost-effectiveness analysis of the measurement of biodiversity indicators

A comprehensive quantification of biodiversity in farming systems would require a very significant amount of work (and funds) even for a small area. Therefore, biodiversity indicators are needed to solve the problem of the measurement feasibility. Even though the issue of cost and effectiveness is central for the evaluation of the indicators, only the latter is discussed in detail in the scientific literature. This work presents a cost analysis based on the direct gathering of records from a farm-scale biodiversity survey (EU-FP7, BioBio - “Indicators for biodiversity in organic and low-input farming systems”) where the analysis of costs is part of the project. It is a simple method for comparing different indicators by their ratio of cost/effectiveness. Here we present the results from the French case study (Gascony Hills, Midi-Pyrenees Region)

Clinical follow-up rather than duplex surveillance after carotid endarterectomy

AbstractPurpose: The value of duplex surveillance and the significance of contralateral carotid disease after endarterectomy have been assessed.Methods: Three hundred five patients were observed prospectively after carotid endarterectomy for a median time of 36 months (range, 6 to 96 months), with duplex surveillance performed at 1 day; 1 week; 3, 6, 9, and 12 months; and then each year after endarterectomy.Results: Thirty patients (10%) had ipsilateral symptoms (13 strokes, 17 transient ischemic attacks [TIAs]) at a median time of 6 months (range, 0 to 60 months). Life table analysis demonstrated that ipsilateral stroke was equally common for patients who had ≥50% restenosis (3% at 36 months) and those who did not (6% at 36 months, p > 0.5). Twenty-three patients (8%) developed symptoms (stroke 5, TIA 14) attributable to the contralateral carotid artery at a median time of 9 months (range, 0 to 36 months) after endarterectomy. By life table analysis, 40% of patients with 70% to 99%, 6% with 50% to 69%, 1% with <50% contralateral internal carotid stenosis, and 5% with contralateral carotid occlusion at the time of endarterectomy had a contralateral TIA in the 36 months after endarterectomy ( p < 0.01). However, contralateral stroke was not significantly more common for patients with severe contralateral internal carotid stenosis demonstrated at the time of endarterectomy (<50% stenosis, 0%; 50% to 69%, 3%; 70% to 99%, 7%; occlusion, 6% stroke rate at 36 months). Seven of the 32 patients who developed progression of contralateral disease had a TIA, compared with 11 of 227 patients who did not develop progression of contralateral disease ( p < 0.01). None of the 12 patients who progressed from a <70% to a 70% to 99% contralateral stenosis had a stroke.Conclusions: After carotid endarterectomy restenosis is rarely associated with symptoms; contralateral stroke is rare and is not associated with progressive internal carotid artery disease suitable for endarterectomy. This study has shown no benefit from long-term duplex surveillance after carotid endarterectomy. Selective clinical follow-up of patients who have high-grade contralateral stenoses would appear more appropriate. (J Vasc Surg 1997;25:55-63.

The clinical and cost-effectiveness of a Victim Improvement Package (VIP) for the reduction of chronic symptoms of depression or anxiety in older victims of common crime (the VIP trial): study protocol for a randomised controlled trial.

BACKGROUND: Older people are vulnerable to sustained high levels of psychosocial distress following a crime. A cognitive behavioural therapy (CBT)-informed psychological therapy, the Victim Improvement Package (VIP) may aid recovery. The VIP trial aims to test the clinical and cost-effectiveness of the VIP for alleviating depressive and anxiety symptoms in older victims of crime. METHODS/DESIGN: People aged 65 years or more who report being a victim of crime will be screened by Metropolitan Police Service Safer Neighbourhood Teams within a month of the crime for distress using the Patient Health Questionnaire-2 and the Generalised Anxiety Disorder-2. Those who screen positive will be signposted to their GP for assistance, and re-screened at 3 months. Participants who screen positive for depression and/or anxiety at re-screening are randomised to a CBT informed VIP added to treatment as usual (TAU) compared to TAU alone. The intervention consists of 10 individual 1-h sessions, delivered weekly by therapists from the mental health charity Mind. The primary outcome measure is the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI), used as a composite measure, assessed at 6 months after the crime (post therapy) with a 9-month post-crime follow-up. Secondary outcome measures include the EQ-5D, and a modified Client Service Receipt Inventory. A total of 226 participants will be randomised VIP:TAU with a ratio 1:1, in order to detect a standardised difference of at least 0.5 between groups, using a mixed-effects linear-regression model with 90% power and a 5% significance level (adjusting for therapist clustering and potential drop-out). A cost-effectiveness analysis will incorporate intervention costs to compare overall health care costs and quality of life years between treatment arms. An embedded study will examine the impact of past trauma and engagement in safety behaviours and distress on the main outcomes. DISCUSSION: This trial should provide data on the clinical and cost-effectiveness of a CBT-informed psychological therapy for older victims of crime with anxiety and/or depressive symptoms and should demonstrate a model of integrated cross-agency working. Our findings should provide evidence for policy-makers, commissioners and clinicians responding to the needs of older victims of crime. TRIAL REGISTRATION: International Standard Randomised Controlled Trials Number, ID: ISRCTN16929670. Registered on 3 August 2016

Towards designer organelles by subverting the peroxisomal import pathway

The development of ‘designer’ organelles could be a key strategy to enable foreign pathways to be efficiently controlled within eukaryotic biotechnology. A fundamental component of any such system will be the implementation of a bespoke protein import pathway that can selectively deliver constituent proteins to the new compartment in the presence of existing endogenous trafficking systems. Here we show that the protein–protein interactions that control the peroxisomal protein import pathway can be manipulated to create a pair of interacting partners that still support protein import in moss cells, but are orthogonal to the naturally occurring pathways. In addition to providing a valuable experimental tool to give new insights into peroxisomal protein import, the variant receptor-signal sequence pair forms the basis of a system in which normal peroxisomal function is downregulated and replaced with an alternative pathway, an essential first step in the creation of a designer organelle