1,567 research outputs found

    Real-world evidence in economic evaluations: really realistic?

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    The HARPS search for southern extrasolar planets: XXXIII. New multi-planet systems in the HARPS volume limited sample: a super-Earth and a Neptune in the habitable zone

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    The vast diversity of planetary systems detected to date is defying our capability of understanding their formation and evolution. Well-defined volume-limited surveys are the best tool at our disposal to tackle the problem, via the acquisition of robust statistics of the orbital elements. We are using the HARPS spectrograph to conduct our survey of ~850 nearby solar-type stars, and in the course of the past nine years we have monitored the radial velocity of HD103774, HD109271, and BD-061339. In this work we present the detection of five planets orbiting these stars, with m*sin(i) between 0.6 and 7 Neptune masses, four of which are in two multiple systems, comprising one super-Earth and one planet within the habitable zone of a late-type dwarf. Although for strategic reasons we chose efficiency over precision in this survey, we have the capability to detect planets down to the Neptune and super-Earth mass range, as well as multiple systems, provided that enough data points are made available.Comment: 7 pages, 14 figures, accepted for publication by A&A, 04-01-201

    The HARPS search for southern extrasolar planets. XXIII. 8 planetary companions to low-activity solar-type stars

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    In this paper, we present our HARPS radial-velocity data for eight low-activity solar-type stars belonging to the HARPS volume-limited sample: HD6718, HD8535, HD28254, HD290327, HD43197, HD44219, HD148156, and HD156411. Keplerian fits to these data reveal the presence of low-mass companions around these targets. With minimum masses ranging from 0.58 to 2.54 MJup, these companions are in the planetary mass domain. The orbital periods of these planets range from slightly less than one to almost seven years. The eight orbits presented in this paper exhibit a wide variety of eccentricities: from 0.08 to above 0.8.Comment: 8 pages, 2 figures, accepted for publication in A&

    The HARPS search for southern extra-solar planets. XXVII. Up to seven planets orbiting HD 10180: probing the architecture of low-mass planetary systems

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    Context. Low-mass extrasolar planets are presently being discovered at an increased pace by radial velocity and transit surveys, opening a new window on planetary systems. Aims. We are conducting a high-precision radial velocity survey with the HARPS spectrograph which aims at characterizing the population of ice giants and super-Earths around nearby solar-type stars. This will lead to a better understanding of their formation and evolution, and yield a global picture of planetary systems from gas giants down to telluric planets. Methods. Progress has been possible in this field thanks in particular to the sub-m/s radial velocity precision achieved by HARPS. We present here new high-quality measurements from this instrument. Results. We report the discovery of a planetary system comprising at least five Neptune-like planets with minimum masses ranging from 12 to 25 M_Earth, orbiting the solar-type star HD 10180 at separations between 0.06 and 1.4 AU. A sixth radial velocity signal is present at a longer period, probably due to a 65-M_Earth object. Moreover, another body with a minimum mass as low as 1.4 M_Earth may be present at 0.02 AU from the star. This is the most populated exoplanetary system known to date. The planets are in a dense but still well-separated configuration, with significant secular interactions. Some of the orbital period ratios are fairly close to integer or half-integer values, but the system does not exhibit any mean-motion resonances. General relativity effects and tidal dissipation play an important role to stabilize the innermost planet and the system as a whole. Numerical integrations show long-term dynamical stability provided true masses are within a factor ~3 from minimum masses. We further note that several low-mass planetary systems exhibit a rather "packed" orbital architecture with little or no space left for additional planets. (Abridged)Comment: 20 pages, 15 figures, accepted for publication in A&

    On the non-Gaussianity from Recombination

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    The non-linear effects operating at the recombination epoch generate a non-Gaussian signal in the CMB anisotropies. Such a contribution is relevant because it represents a major part of the second-order radiation transfer function which must be determined in order to have a complete control of both the primordial and non-primordial part of non-Gaussianity in the CMB anisotropies. We provide an estimate of the level of non-Gaussianity in the CMB arising from the recombination epoch which shows up mainly in the equilateral configuration. We find that it causes a contamination to the possible measurement of the equilateral primordial bispectrum shifting the minimum detectable value of the non-Gaussian parameter f^equil_NL by Delta f^equil_NL= O(10) for an experiment like Planck.Comment: LaTeX file; 11 pages. v2: Typos corrected; references added; comments about the effective non-linearity parameter added in Sec. IV; comments added in the conclusions of Sec. IV. v3: References added; some clarifications added as footnotes 4 and 6, and in Sec. 3. Matches version accepted for publication in JCA

    Toward a common aggregation mechanism for a β-barrel protein family: insights derived from a stable dimeric species

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    Δ78Δ is a second generation functional all-β sheet variant of IFABP (intestinal fatty acid binding protein) corresponding to the fragment 29-106 of the parent protein. This protein and its predecessor, Δ98Δ (segment 29-126 of IFABP), were initially uncovered by controlled proteolysis. Remarkably, although IFABP and Δ98Δ are monomers in solution, Δ78Δ adopts a stable dimeric structure. With the aim of identifying key structural features that modulate the aggregation of β-proteins, we evaluate here the structure and aggregation propensity of Δ78Δ. The 2,2,2-trifluoroethanol (TFE) induced aggregation of this protein shows a primary nucleation-elongation mechanism, characterized by the stabilization of a dimeric nucleus. Its rate of production from the co-solvent induced aggregation prone state governs the kinetics of polymerization. In this context, the value of Δ78Δ lies in the fact that - being a stable dimeric species - it reduces an otherwise bimolecular reaction to a unimolecular one. Interestingly, even though Δ78Δ and IFABP display similar conformational stability, the abrogated form of IFABP shows an enhanced aggregation rate, revealing the ancillary role played on this process by the free energy of the native proteins. Δ78Δ share with IFABP and Δ98Δ a common putative aggregation-prone central peptide. Differences in the exposure/accessibility of this segment dictated by the environment around this region might underlie the observed variations in the speed of aggregation. Lessons learnt from this natural dimeric protein might shed light on the early conformational events leading to β-conversion from barrels to amyloid aggregates.Fil: Angelani, Carla Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; ArgentinaFil: Curto, Lucrecia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; ArgentinaFil: Cabanas, Inés S. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; ArgentinaFil: Caramelo, Julio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; ArgentinaFil: Uversky, Vladimir N. Russian Academy of Sciences. Institute for Biological Instrumentation; Rusia. University of South Florida. Department of Molecular Medicine; Estados UnidosFil: Delfino, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentin

    The HARPS search for southern extra-solar planets. XXIV. Companions to HD 85390, HD 90156 and HD 103197: A Neptune analogue and two intermediate mass planets

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    We report the detection of three new extrasolar planets orbiting the solar type stars HD 85390, HD 90156 and HD 103197 with the HARPS spectrograph mounted on the ESO 3.6-m telescope at La Silla observatory. HD 85390 has a planetary companion with a projected intermediate mass (42.0 Earth masses) on a 788-day orbit (a=1.52 AU) with an eccentricity of 0.41, for which there is no analogue in the solar system. A drift in the data indicates the presence of another companion on a long period orbit, which is however not covered by our measurements. HD 90156 is orbited by a warm Neptune analogue with a minimum mass of 17.98 Earth masses (1.05 Neptune masses), a period of 49.8 days (a=0.25 AU) and an eccentricity of 0.31. HD 103197 has an intermediate mass planet on a circular orbit (P=47.8 d, Msini=31.2 Earth masses). We discuss the formation of planets of intermediate mass (about 30-100 Earth masses) which should be rare inside a few AU according to core accretion formation models.Comment: 9 pages, 5 figures. Accepted to A&
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