Synthesis and pharmacological activity of 4-carbamoyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones

A new series of 4-carbamoyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones 4a-g have been synthesized and tested for their anti-inflammatory and analgesic properties. Among the tested compounds, only 4f at 1 mmole/Kg showed antiinflammatory activity that was comparable with that of indomethacin (5 mg/Kg) though of shorter duration. Compounds 4a, 4e and especially 4g at 0.2 mmoles/Kg displayed relevant analgesic activity, 4g being the most potent derivative in the writhing test. Compounds 4c and 4g were found to possess analgesic activity also in the hot plate test

Synthesis and pharmacological activity of 4-carbamoyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones

A new series of 4-carbamoyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones 4a-g have been synthesized and tested for their anti-inflammatory and analgesic properties. Among the tested compounds, only 4f at 1 mmole/Kg showed antiinflammatory activity that was comparable with that of indomethacin (5 mg/Kg) though of shorter duration. Compounds 4a, 4e and especially 4g at 0.2 mmoles/Kg displayed relevant analgesic activity, 4g being the most potent derivative in the writhing test. Compounds 4c and 4g were found to possess analgesic activity also in the hot plate test

Pirazoli triciclici: sintesi e valutazione biologica di ligandi per i recettori cannabinoidei con struttura diidroindenopirazolica contenenti differenti sostituenti carbossammidici

I recettori cannabinoidei CB2, membri della famiglia dei recettori accoppiati alla proteina G, hanno assunto notevole interesse quali bersagli farmaceutici per un potenziale impiego terapeutico in un’ampia varietà di malattie. Come parte del nostro continuo interesse verso i ligandi CB2, abbiamo intrapreso studi volti alla preparazione di nuovi composti correlati ad 1a in cui lo spezzone sul C3è stato modificato con differenti gruppi carbossammidici (1b-n). Nella sezione poster descriviamo la sintesi e la valutazione biologica dei nuovi analoghi di 1a, 1b-n