Photo-controlled permeation of spiropyran modified gramicidin A ion channel

Thesis (M.S.) University of Alaska Fairbanks, 2006Biomimetic devices show great potential as being molecular sensors of biological species. Gramicidin A (gA) is a well studied ionophore that can be easily modified at the C-terminus to be incorporated into phosphotidylcholine bilayer membrane systems. Potassium permeation of modified gA attached to spiropyran can be controlled with light. Upon ultra-violet irradiation spiropyran transforms to the more polar form merocyanine. The process back to spiropyran is completely reversible upon irradiation with 550 nm light or thermally. Free bilayer membrane vesicles are employed to describe the characteristics of modified ion channels. Characteristics of gA modified with spiropyran are described herein. A device has been created and characterized using electrochemical impedance spectroscopy to analyze potassium permeation through a tethered bilayer membrane system (tBMS) on a sheet of gold utilizing sulfur anchors. The device consists of a tethered phase and a mobile upper phase. The mobile lipid layer incorporates gA modified with spiropyran. The modification allows for control of potassium permeation across the tBMS. Impedance analysis shows good agreement with the ability to control potassium permeation to that of the free vesicle

Employer-Sponsored Pensions: A Primer

The shifting pension landscape raises questions about the financial security of future retirees. About one-half of private-sector workers are not covered by employer-sponsored pension plans on their current job. Many private-sector employers have replaced traditional pensions with 401(k)-type plans, which protect benefits for workers who change jobs frequently but expose participants to investment risks. This primer describes pensions, workers with coverage, and related policy issues

Cannibalism as a life boat mechanism

Under certain conditions a cannibalistic population can survive when food for the adults is too scarce to support a non-cannibalistic population. Cannibalism can have this lifeboat effect if (i) the juveniles feed on a resource inaccessible to the adults; and (ii) the adults are cannibalistic and thus incorporate indirectly the inaccessible resource. Using a simple model we conclude that the mechanism works when, at low population densities, the average yield, in terms of new offspring, due to the energy provided by one cannibalized juvenile is larger than one

Lifting Bell inequalities

A Bell inequality defined for a specific experimental configuration can always be extended to a situation involving more observers, measurement settings, or measurement outcomes. In this article, such "liftings" of Bell inequalities are studied. It is shown that if the original inequality defines a facet of the polytope of local joint outcome probabilities then the lifted one also defines a facet of the more complex polytope

High-resolution infrared spectroscopy as a tool to detect false positives of transit search programs

Transit search programs such as CoRoT and Kepler now have the capability of detecting planets as small as the Earth. The detection of these planets however requires the removal of all false positives. Although many false positives can be identified by a detailed analysis of the LCs, the detections of others require additional observations. An important source of false positives are faint eclipsing binaries within the PSF of the target stars. We develop a new method that allows us to detect faint eclipsing binaries with a separation smaller than one arcsec from target stars. We thereby focus on binaries that mimic the transits of terrestrial planets. These binaries can be either at the same distance as the target star (triple stars), or at either larger, or smaller distances. A close inspection of the problem indicates that in all relevant cases the binaries are brighter in the infrared than in the optical regime. We show how high resolution IR spectroscopy can be used to remove these false positives. For the triple star case, we find that the brightness difference between a primary and an eclipsing secondary is about 9-10 mag in the visual but only about 4.5-5.9 magnitudes in the K-band. We demonstrate how the triple star hypothesis can be excluded by taking a high-resolution IR spectrum. Simulations of these systems show that the companions can be detected with a false-alarm probability of 2%, if the spectrum has a S/N-ratio > 100. We show that high-resolution IR spectra also allows to detect most of the false positives caused by foreground or background binaries. If high resolution IR spectroscopy is combined with photometric methods, virtually all false positives can be detected without RV measurements. It is thus possible to confirm transiting terrestrial planets with a modest investment of observing time.Comment: 6 pages, 7 figure

The very nearby M/T dwarf binary SCR 1845-6357

The recently discovered star SCR 1845-6357 is the first late M/T dwarf binary discovered. SCR 1845 is a particular object due to its tight orbit (currently around 4 AU) and its proximity to the Sun (3.85 pc). We present spatially resolved VLT/NACO images and low resolution spectra of SCR 1845 in the J, H and K near-infrared bands. Since the T dwarf companion, SCR 1845B, is so close to the primary SCR 1845A, orbital motion is evident even within a year. Following the orbital motion, the binary's mass can be measured accurately within a decade, making SCR 1845B a key T-dwarf mass-luminosity calibrator. The NIR spectra allow for accurate determination of spectral type and also for rough estimates of the object's physical parameters. The spectral type of SCR 1845B is determined by direct comparison of the flux calibrated JHK spectra with T dwarf standard template spectra and also by NIR spectral indices obtained from synthetic photometry. Constrained values for surface gravity, effective temperature and metallicity are derived by comparison with model spectra. Our data prove that SCR 1845B is a brown dwarf of spectral type T6 that is co-moving with and therefore gravitationally bound to the M8.5 primary. Fitting the NIR spectrum of SCR 1845B to model spectra yields an effective temperature of about 950K and a surface gravity log(g)=5.1 (cgs) assuming solar metallicity. Mass and age of SCR 1845B are in the range 40 to 50 Jupiter masses and 1.8 to 3.1 Gyr.Comment: 5 pages, 4 figures, accepted for publication in Astronomy & Astrophysic

Quantum mechanics is about quantum information

I argue that quantum mechanics is fundamentally a theory about the representation and manipulation of information, not a theory about the mechanics of nonclassical waves or particles. The notion of quantum information is to be understood as a new physical primitive -- just as, following Einstein's special theory of relativity, a field is no longer regarded as the physical manifestation of vibrations in a mechanical medium, but recognized as a new physical primitive in its own right.Comment: 17 pages, forthcoming in Foundations of Physics Festschrift issue for James Cushing. Revised version: some paragraphs have been added to the final section clarifying the argument, and various minor clarifying remarks have been added throughout the tex

The discovery of a T6.5 subdwarf

We report the discovery of ULAS J131610.28+075553.0, an sdT6.5 dwarf in the UKIDSS Large Area Survey 2 epoch proper motion catalogue. This object displays significant spectral peculiarity, with the largest yet seen deviations from T6 and T7 templates in the Y and K bands for this subtype. Its large, similar to 1 arcsec yr(-1), proper motion suggests a large tangential velocity of V-tan approximate to 240-340 km s(-1), if we assume its M-J lies within the typical range for T6.5 dwarfs. This makes it a candidate for membership of the Galactic halo population. However, other metal-poor T dwarfs exhibit significant under luminosity both in specific bands and bolometrically. As a result, it is likely that its velocity is somewhat smaller, and we conclude it is a likely thick disc or halo member. This object represents the only T dwarf earlier than T8 to be classified as a subdwarf, and is a significant addition to the currently small number of known unambiguously substellar subdwarfs.Peer reviewe