The enlargement of the Suez Canal and introduction of non-indigenous species to the Mediterranean Sea

The Suez Canal is one of the most important waterways in the world – during the last year 17,148 ships passed through the Canal – reducing emissions, saving time, and operating costs to shippers. The rapid increase in ship size from the “Post-Suezmax” (> 12,000 TEU) to the latest container vessels (> 19,000 TEU) now requires enlargements of port facilities and canals. A project of this magnitude, and with potentially negative environmental outcomes, requires a transparent and scientifically sound “Environmental Impact Assessment” (EIA). An explicit obligation on Parties to the Convention on Biological Diversity (https://www.cbd.int/doc/ legal/cbd-en.pdf) was made to consider transboundary impacts on biodiversity, particularly those associated with invasive non-indigenous species

Classification of non-indigenous species based on their impacts: Considerations for application in marine management

Assessment of the ecological and economic/societal impacts of the introduction of non-indigenous species (NIS) is one of the primary focus areas of bioinvasion science in terrestrial and aquatic environments, and is considered essential to management. A classification system of NIS, based on the magnitude of their environmental impacts, was recently proposed to assist management. Here, we consider the potential application of this classification scheme to the marine environment, and offer a complementary framework focussing on value sets in order to explicitly address marine management concerns. Since existing data on marine NIS impacts are scarce and successful marine removals are rare, we propose that management of marine NIS adopt a precautionary approach, which not only would emphasise preventing new incursions through pre-border and at-border controls but also should influence the categorisation of impacts. The study of marine invasion impacts requires urgent attention and significant investment, since we lack the luxury of waiting for the knowledge base to be acquired before the window of opportunity closes for feasible management

Granulocyte macrophage colony-stimulating factor receptor α expression and its targeting in antigen-induced arthritis and inflammation

A Representative FACS plots showing Ly6G and Ly6C staining of CD45+ myeloid populations in the AIA knee joint. F4/80intSSchi eosinophils (Eos), F4/80+CD11c+MHCII+ Mo-DCs (R1), F4/80+CD11c-MHCII+ macrophages (Macs) (R2), F4/80+CD11c-MHCII- macrophages (R3), F4/80-CD11c+ MHCII+ cDCs, F4/80-CD11b+Ly6G+ neutrophils, which are also Ly6C+, and F4/80-CD11b+Ly6G-SScloLy6C+/- monocytes. B Representative FACS plots of CD45+ myeloid populations in the AIA knee joint showing Ly6G+ neutrophils are CD64- and F4/80+ macrophages/Mo-DCs are CD64+. (PDF 235 kb

A New Balance: Weighing Harms of Hiding Police Misconduct Information from the Public

Three New York City events in the past two years have demonstrated how hiding information related to police misconduct harms its residents. In April 2016, the New York Police Department (“NYPD”) eliminated public access to misconduct information by taking down a clipboard in the Deputy Commissioner of Public Information’s office that posted disciplinary summaries and removing decades worth of archives of those same summaries from City Hall. In September 2017, an Administrative Law Judge employed by the NYPD closed from the public a courtroom where a former officer was about to be impeached with his prior disciplinary record. In April 2018, four plainclothes police officers shot Mr. Saheed Vassell dead in broad daylight. The Mayor and Police Commissioner never named these officers, while the NYPD aggressively sought to manipulate public opinion towards a conclusion that the officers’ shooting was justified and more generally that NYPD officers are restrained in using violence against unarmed civilians. This article argues that police privacy protections enacted in state statutes across the country cause greater harm to individuals, public trust in justice systems, and democratic decision-making than access to police misconduct information harms individual police officers. People harmed by hiding police officer misconduct include families who lost loved ones to police violence, communities uncertain if dangerous officers are still a threat, and everyone who witnesses how impossible it seems to hold officers accountable. These harms spread across cities and states and are passed down through generations. Previously prioritized police privacy concerns will be examined closely and weighed carefully in relation to the actual harms they can cause. A new balance will conclude that the harms caused by police privacy protections to the public significantly outweigh transparency’s potential harm to police officers’ privacy

Sequential Scanning Electron Microscopic Analyses of Normal and Spontaneously Occurring Abnormal Ocular Development in C57B1/6J Mice

Embryos of C57B1/6J mice were examined grossly, and by light and scanning electron microscopy on days 8 through 19 of gestation. Adult eyes were examined by slit lamp biomicroscopy and light microscopy. A spontaneous incidence of eye malformations including microphthalmia, microphakia, corneal opacity and anterior segment dysgenesis was observed at a rate of 13.2% in the adults and 10.8% in the day 14 embryos. Scanning electron microscopy demonstrates the complex series of coordinated changes in shape and tissue interrelationships observed in normal ocular development. Possible routes of abnormal ocular morphogenesis beginning as early as the time of optic vesicle formation are discussed

Laminin and fibronectin in retinoid-induced keratolenticular dysgenesis.

Acute embryonic exposure to isotretinoin during gastrulation (gestational day 7) in the mouse results in delay or failure of separation of the lens vesicle from the surface ectoderm. During normal lens vesicle detachment, laminin is localized within the lens, keratolenticular stalk and adjacent surface ectoderm. The mesenchyme surrounding the stalk stains positively for fibronectin. In contrast, isotretinoin-exposed embryos at the same stage of gestation exhibit reduced staining for both extracellular matrix components. Persistent keratolenticular attachment observed later in gestation in the exposed embryos is associated with increased production of laminin by the keratolenticular stalk and anterior lens epithelium. A delay in the sequence of production of extracellular matrix may be causally associated with persistence of the keratolenticular stalk

'Double trouble': the expansion of the Suez Canal and marine bioinvasions in the Mediterranean Sea

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