Shutdown is a component of the Drosophila piRNA biogenesis machinery

In animals, the piRNA pathway preserves the integrity of gametic genomes, guarding them against the activity of mobile genetic elements. This innate immune mechanism relies on distinct genomic loci, termed piRNA clusters, to provide a molecular definition of transposons, enabling their discrimination from genes. piRNA clusters give rise to long, single-stranded precursors, which are processed into primary piRNAs through an unknown mechanism. These can engage in an adaptive amplification loop, the ping-pong cycle, to optimize the content of small RNA populations via the generation of secondary piRNAs.Many proteins have been ascribed functions in either primary biogenesis or the ping-pong cycle, though for the most part the molecular functions of proteins implicated in these pathways remain obscure. Here, we link shutdown (shu), a gene previously shown to be required for fertility in Drosophila, to the piRNA pathway. Analysis of knockdown phenotypes in both the germline and somatic compartments of the ovary demonstrate important roles for shutdown in both primary biogenesis and the ping-pong cycle. shutdown is a member of the FKBP family of immunophilins. Shu contains domains implicated in peptidyl-prolyl cis-trans isomerase activity and in the binding of HSP90-family chaperones, though the relevance of these domains to piRNA biogenesis is unknown. Published by Cold Spring Harbor Laboratory Press. Copyright © 2012 RNA Society

The Gravity Dual of a Density Matrix

For a state in a quantum field theory on some spacetime, we can associate a density matrix to any subset of a given spacelike slice by tracing out the remaining degrees of freedom. In the context of the AdS/CFT correspondence, if the original state has a dual bulk spacetime with a good classical description, it is natural to ask how much information about the bulk spacetime is carried by the density matrix for such a subset of field theory degrees of freedom. In this note, we provide several constraints on the largest region that can be fully reconstructed, and discuss specific proposals for the geometric construction of this dual region.Comment: 19 pages, LaTeX, 8 figures, v2: footnote and reference adde

Polarizing Bubble Collisions

We predict the polarization of cosmic microwave background (CMB) photons that results from a cosmic bubble collision. The polarization is purely E-mode, symmetric around the axis pointing towards the collision bubble, and has several salient features in its radial dependence that can help distinguish it from a more conventional explanation for unusually cold or hot features in the CMB sky. The anomalous "cold spot" detected by the Wilkinson Microwave Anisotropy Probe (WMAP) satellite is a candidate for a feature produced by such a collision, and the Planck satellite and other proposed surveys will measure the polarization on it in the near future. The detection of such a collision would provide compelling evidence for the string theory landscape.Comment: Published version. 15 pages, 8 figure

Bubble collisions and measures of the multiverse

To compute the spectrum of bubble collisions seen by an observer in an eternally-inflating multiverse, one must choose a measure over the diverging spacetime volume, including choosing an "initial" hypersurface below which there are no bubble nucleations. Previous calculations focused on the case where the initial hypersurface is pushed arbitrarily deep into the past. Interestingly, the observed spectrum depends on the orientation of the initial hypersurface, however one's ability observe the effect rapidly decreases with the ratio of inflationary Hubble rates inside and outside one's bubble. We investigate whether this conclusion might be avoided under more general circumstances, in particular placing the observer's bubble near the initial hypersurface. We find that it is not. As a point of reference, a substantial appendix reviews relevant aspects of the measure problem of eternal inflation.Comment: 24 pages, two figures, plus 16-page appendix with one figure; v2: minor improvements and clarifications, conclusions unchanged (version to appear in JCAP

A Theory of a Spot

We present a simple inflationary scenario that can produce arbitrarily large spherical underdense or overdense regions embedded in a standard Lambda cold dark matter paradigm, which we refer to as bubbles. We analyze the effect such bubbles would have on the Cosmic Microwave Background (CMB). For super-horizon sized bubble in the vicinity of the last scattering surface, a signal is imprinted onto CMB via a combination of Sach-Wolfe and an early integrated Sach-Wolfe (ISW) effects. Smaller, sub-horizon sized bubbles at lower redshifts (during matter domination and later) can imprint secondary anisotropies on the CMB via Rees-Sciama, late-time ISW and Ostriker-Vishniac effects. Our scenario, and arguably most similar inflationary models, produce bubbles which are over/underdense in potential: in density such bubbles are characterized by having a distinct wall with the interior staying at the cosmic mean density. We show that such models can potentially, with only moderate fine tuning, explain the \emph{cold spot}, a non-Gaussian feature identified in the Wilkinson Microwave Anisotropy Probe (WMAP) data by several authors. However, more detailed comparisons with current and future CMB data are necessary to confirm (or rule out) this scenario.Comment: 19 pages, 19 figures, added references and explanations, JCAP in pres

Universal scaling properties of extremal cohesive holographic phases

We show that strongly-coupled, translation-invariant holographic IR phases at finite density can be classified according to the scaling behaviour of the metric, the electric potential and the electric flux introducing four critical exponents, independently of the details of the setup. Solutions fall into two classes, depending on whether they break relativistic symmetry or not. The critical exponents determine key properties of these phases, like thermodynamic stability, the (ir)relevant deformations around them, the low-frequency scaling of the optical conductivity and the nature of the spectrum for electric perturbations. We also study the scaling behaviour of the electric flux through bulk minimal surfaces using the Hartnoll-Radicevic order parameter, and characterize the deviation from the Ryu-Takayanagi prescription in terms of the critical exponents.Comment: v4: corrected a typo in eqn (3.29), now (3.28). Conclusions unchange

Analytical and computational study of magnetization switching in kinetic Ising systems with demagnetizing fields

An important aspect of real ferromagnetic particles is the demagnetizing field resulting from magnetostatic dipole-dipole interaction, which causes large particles to break up into domains. Sufficiently small particles, however, remain single-domain in equilibrium. This makes such small particles of particular interest as materials for high-density magnetic recording media. In this paper we use analytic arguments and Monte Carlo simulations to study the effect of the demagnetizing field on the dynamics of magnetization switching in two-dimensional, single-domain, kinetic Ising systems. For systems in the ``Stochastic Region,'' where magnetization switching is on average effected by the nucleation and growth of fewer than two well-defined critical droplets, the simulation results can be explained by the dynamics of a simple model in which the free energy is a function only of magnetization. In the ``Multi-Droplet Region,'' a generalization of Avrami's Law involving a magnetization-dependent effective magnetic field gives good agreement with our simulations.Comment: 29 pages, REVTeX 3.0, 10 figures, 2 more figures by request. Submitted Phys. Rev.

Isotopic Dependence of the Nuclear Caloric Curve

The A/Z dependence of projectile fragmentation at relativistic energies has been studied with the ALADIN forward spectrometer at SIS. A stable beam of 124Sn and radioactive beams of 124La and 107Sn at 600 MeV per nucleon have been used in order to explore a wide range of isotopic compositions. Chemical freeze-out temperatures are found to be nearly invariant with respect to the A/Z of the produced spectator sources, consistent with predictions for expanded systems. Small Coulomb effects (\Delta T \approx 0.6 MeV) appear for residue production near the onset of multifragmentation.Comment: 11 pages, 3 figures, accepted for publ. in Phys. Rev. Let

Tracing a phase transition with fluctuations of the largest fragment size: Statistical multifragmentation models and the ALADIN S254 data

A phase transition signature associated with cumulants of the largest fragment size distribution has been identified in statistical multifragmentation models and examined in analysis of the ALADIN S254 data on fragmentation of neutron-poor and neutron-rich projectiles. Characteristics of the transition point indicated by this signature are weakly dependent on the A/Z ratio of the fragmenting spectator source. In particular, chemical freeze-out temperatures are estimated within the range 5.9 to 6.5 MeV. The experimental results are well reproduced by the SMM model.Comment: 7 pages, 3 figures, Proceedings of the International Workshop on Multifragmentation and Related Topics (IWM2009), Catania, Italy, November 2009

Neutron recognition in the LAND detector for large neutron multiplicity

The performance of the LAND neutron detector is studied. Using an event-mixing technique based on one-neutron data obtained in the S107 experiment at the GSI laboratory, we test the efficiency of various analytic tools used to determine the multiplicity and kinematic properties of detected neutrons. A new algorithm developed recently for recognizing neutron showers from spectator decays in the ALADIN experiment S254 is described in detail. Its performance is assessed in comparison with other methods. The properties of the observed neutron events are used to estimate the detection efficiency of LAND in this experiment.Comment: 16 pages, 8 figure