19 research outputs found
Treatment of Hepatocellular Carcinoma in Children - Analysis of Criteria for Transplantation - 26 Years of Experience in Single Center
1288 INCREASED EXPRESSION OF TRANSCRIPTION FACTOR FOX03A AND PROAPOPTOTIC PROTEIN BIM IN PRIMARY BILIARY CIRRHOSIS BUT NOT IN PRIMARY SCLEROSING CHOLANGITIS
Revitalisation of tenements from the 13th and early 20th centuries in Gliwice – a case
Artykuł prezentuje dwa przykłady rewitalizacji kamienic z XIII i początku XX w. zlokalizowanych w Gliwicach. Poprzez zastosowaną metodykę badawczą oraz innowacyjne rozwiązania projektowe udało się „uratować” obiekty przed rozbiórką, wykonać skomplikowany remont i oddać do użytkowania. Wykazano, że możliwa jest synergia dbałości o zachowanie historycznego charakteru wizerunku ze współczesnymi oczekiwaniami. Takie podejście do procesu inwestycyjnego, a w szczególności przedprojektowego dało zadowalające rezultaty dla wszystkich stron: użytkowników, konserwatora miejskiego, projektantów. Dobre rozeznanie przedprojektowe oraz odważne decyzje projektowe pozwoliły na skuteczne ratowanie obiektów zabytkowych. Tkance miejskiej przywrócono wyremontowane obiekty o wysokiej jakości technicznej, estetycznej i funkcjonalnej zgodnie ze współczesnymi potrzebami i oczekiwaniami.The article presents two examples of revitalization of tenement houses from the 13th and early 20th centuries located in Gliwice. Through the applied research methodology and innovative design solutions it was possible to "save" the buildings from demolition, carry out a complex renovation and put them back into use. It has been demonstrated that it is possible to synergise the care of preserving the historic character of an image with contemporary expectations. This approach to the investment process, and in particular the pre-design process, produced satisfactory results for all parties: users, the urban conservationist, designers. Good predesign knowledge and courageous design decisions made it possible to successfully save historic buildings. Renovated buildings of high technical, aesthetic and functional quality were restored to the urban tissue in accordance with contemporary needs and expectations
Proapoptotic protein bim and its upstream activator Foxo3A are overexpressed in primary biliary cirrhosis but not in primary sclerosing cholangitis
MON-PO485: Assessment of the Physical Development of Children After Oesophageal Reconstruction – 10 Years Follow-Up
848 THE EVALUATION OF MULTISPECIES PROBIOTICS IN PORTAL HYPERTENSION – CYTOKINES INVOLVED IN THE PATHOGENESIS OF HEPATO-RENAL SYNDROME ARE NOT MANIPULATED
Health Status in Long-Term Survivors of Hepatoblastoma
The aim of this study was to evaluate the health status of children cured from hepatoblastoma. Forty-five patients with hepatoblastoma treated between 1996–2014 were assessed. The recorded data included sex, age at diagnosis, disease stage, treatment methods, time since diagnosis, and the evaluation of health status domains which included performance status, growth development, hearing, cardiovascular, skeletal, gastrointestinal, genitourinary, neurological, and hematological function. There were 30 boys and 15 girls. The age at diagnosis ranged from one month to 14 years (median one year). At the time of the health status evaluation, the youngest patient was 5.5 years old and the oldest was 21 years of age (median—10 years). All patients were treated according to the Childhood Liver Tumors Strategy Group—SIOPEL recommendations, though they were not active participants of the studies. The median cumulative dose of cisplatin was 520 mg/m2 and 360 mg/m2 for doxorubicin. Thirty-six patients underwent partial hepatectomy, and nine total hepatectomy and liver transplantation. At a median of nine years from diagnosis, 68% of hepatoblastoma survivors had experienced at least one chronic health condition of any grade. The most frequent late complication was ototoxicity (28.8%), and the most serious were second malignancies (6.6%) and cardiomyopathy (4.4%). Conclusion: Survivors of hepatoblastoma are at risk for long-term complications. They require long-term monitoring for late effects
