The circumstellar disc around the Herbig AeBe star HD169142

We present 7 mm and 3.5 cm wavelength continuum observations toward the Herbig AeBe star HD169142 performed with the Very Large Array (VLA) with an angular resolution of ~1". We find that this object exhibits strong (~4.4 mJy), unresolved (~1") 7 mm continuum emission, being one of the brightest isolated Herbig AeBe stars ever detected with the VLA at this wavelength. No emission is detected at 3.5 cm continuum, with a 3 sigma upper limit of ~0.08 mJy. From these values, we obtain a spectral index of ~2.5 in the 3.5 cm to 7 mm wavelength range, indicating that the observed flux density at 7mm is most likely dominated by thermal dust emission coming from a circumstellar disc. We use available photometric data from the literature to model the spectral energy distribution (SED) of this object from radio to near-ultraviolet frequencies. The observed SED can be understood in terms of an irradiated accretion disc with low mass accretion rate, 10^{-8} solar masses per year, surrounding a star with an age of ~10 Myr. We infer that the mass of the disc is ~0.04 solar masses, and is populated by dust grains that have grown to a maximum size of 1 mm everywhere, consistent with the lack of silicate emission at 10 microns. These features, as well as indications of settling in the wall at the dust destruction radius, led us to speculate the disc of HD169142 is in an advanced stage of dust evolution, particularly in its inner regions.Comment: 13 pages, 2 figures. Accepted by MNRA

On the Evolution and Survival of Protoplanets Embedded in a Protoplanetary Disk

We model the evolution of a Jupiter-mass protoplanet formed by the disk instability mechanism at various radial distances accounting for the presence of the disk. Using three different disk models, it is found that a newly-formed Jupiter-mass protoplanet at radial distance of $\lesssim$ 5-10 AU cannot undergo a dynamical collapse and evolve further to become a gravitational bound planet. We therefore conclude that {\it giant planets, if formed by the gravitational instability mechanism, must form and remain at large radial distances during the first $\sim$ 10$^5-10^6$ years of their evolution}. The minimum radial distances in which protoplanets of 1 Saturn-mass, 3 and 5 Jupiter-mass protoplanets can evolve using a disk model with $\dot{M}=10^{-6} M_{Sun}/yr$ and $\alpha=10^{-2}$ are found to be 12, 9, and 7 AU, respectively. The effect of gas accretion on the planetary evolution of a Jupiter-mass protoplanet is also investigated. It is shown that gas accretion can shorten the pre-collapse timescale substantially. Our study suggests that the timescale of the pre-collapse stage does not only depend on the planetary mass, but is greatly affected by the presence of the disk and efficient gas accretion.Comment: 26 pages, 2 tables, 10 figures. Accepted for publication in Ap

A Spatially Resolved Inner Hole in the Disk around GM Aurigae

We present 0.3 arcsec resolution observations of the disk around GM Aurigae with the Submillimeter Array (SMA) at a wavelength of 860 um and with the Plateau de Bure Interferometer at a wavelength of 1.3 mm. These observations probe the distribution of disk material on spatial scales commensurate with the size of the inner hole predicted by models of the spectral energy distribution. The data clearly indicate a sharp decrease in millimeter optical depth at the disk center, consistent with a deficit of material at distances less than ~20 AU from the star. We refine the accretion disk model of Calvet et al. (2005) based on the unresolved spectral energy distribution (SED) and demonstrate that it reproduces well the spatially resolved millimeter continuum data at both available wavelengths. We also present complementary SMA observations of CO J=3-2 and J=2-1 emission from the disk at 2" resolution. The observed CO morphology is consistent with the continuum model prediction, with two significant deviations: (1) the emission displays a larger CO J=3-2/J=2-1 line ratio than predicted, which may indicate additional heating of gas in the upper disk layers; and (2) the position angle of the kinematic rotation pattern differs by 11 +/- 2 degrees from that measured at smaller scales from the dust continuum, which may indicate the presence of a warp. We note that photoevaporation, grain growth, and binarity are unlikely mechanisms for inducing the observed sharp decrease in opacity or surface density at the disk center. The inner hole plausibly results from the dynamical influence of a planet on the disk material. Warping induced by a planet could also potentially explain the difference in position angle between the continuum and CO data sets.Comment: 12 pages, 6 figures, accepted for publication in Ap

Empirical Constraints on Turbulence in Protoplanetary Accretion Disks

We present arcsecond-scale Submillimeter Array observations of the CO(3-2) line emission from the disks around the young stars HD 163296 and TW Hya at a spectral resolution of 44 m/s. These observations probe below the ~100 m/s turbulent linewidth inferred from lower-resolution observations, and allow us to place constraints on the turbulent linewidth in the disk atmospheres. We reproduce the observed CO(3-2) emission using two physical models of disk structure: (1) a power-law temperature distribution with a tapered density distribution following a simple functional form for an evolving accretion disk, and (2) the radiative transfer models developed by D'Alessio et al. that can reproduce the dust emission probed by the spectral energy distribution. Both types of models yield a low upper limit on the turbulent linewidth (Doppler b-parameter) in the TW Hya system (<40 m/s), and a tentative (3-sigma) detection of a ~300 m/s turbulent linewidth in the upper layers of the HD 163296 disk. These correspond to roughly <10% and 40% of the sound speed at size scales commensurate with the resolution of the data. The derived linewidths imply a turbulent viscosity coefficient, alpha, of order 0.01 and provide observational support for theoretical predictions of subsonic turbulence in protoplanetary accretion disks.Comment: 18 pages, 9 figures, accepted for publication in Ap

Spitzer observations of the Orion OB1 association: disk census in the low mass stars

We present new Spitzer Space Telescope observations of two fields in the Orion OB1 association. We report here IRAC/MIPS observations for 115 confirmed members and 41 photometric candidates of the ~10 Myr 25 Orionis aggregate in the OB1a subassociation, and 106 confirmed members and 65 photometric candidates of the 5 Myr region located in the OB1b subassociation. The 25 Orionis aggregate shows a disk frequency of 6% while the field in the OB1b subassociation shows a disk frequency of 13%. Combining IRAC, MIPS and 2MASS photometry we place stars bearing disks in several classes: stars with optically thick disks (class II systems), stars with an inner transitional disks (transitional disk candidates) and stars with "evolved disks"; the last exhibit smaller IRAC/MIPS excesses than class II systems. In all, we identify 1 transitional disk candidate in the 25 Orionis aggregate and 3 in the OB1b field; this represents ~10% of the disk bearing stars, indicating that the transitional disk phase can be relatively fast. We find that the frequency of disks is a function of the stellar mass, suggesting a maximum around stars with spectral type M0. Comparing the infrared excess in the IRAC bands among several stellar groups we find that inner disk emission decays with stellar age, showing a correlation with the respective disk frequencies. The disk emission at the IRAC and MIPS bands in several stellar groups indicates that disk dissipation takes place faster in the inner region of the disks. Comparison with models of irradiated accretion disks, computed with several degrees of settling, suggests that the decrease in the overall accretion rate observed in young stellar groups is not sufficient to explain the weak disk emission observed in the IRAC bands for disk bearing stars with ages 5 Myr or older.Comment: Accepted in the Astrophysical Journa

A Spitzer view of protoplanetary disks in the gamma Velorum cluster

We present new Spitzer Space Telescope observations of stars in the young ~5 Myr gamma Velorum stellar cluster. Combining optical and 2MASS photometry, we have selected 579 stars as candidate members of the cluster. With the addition of the Spitzer mid-infrared data, we have identified 5 debris disks around A-type stars, and 5-6 debris disks around solar-type stars, indicating that the strong radiation field in the cluster does not completely suppress the production of planetesimals in the disks of cluster members. However, we find some evidence that the frequency of circumstellar primordial disks is lower, and the IR flux excesses are smaller than for disks around stellar populations with similar ages. This could be evidence for a relatively fast dissipation of circumstellar dust by the strong radiation field from the highest mass star(s) in the cluster. Another possibility is that gamma Velorum stellar cluster is slightly older than reported ages and the the low frequency of primordial disks reflects the fast disk dissipation observed at ~5 Myr.Comment: Accepted for publication in the Astrophysical Journal: 32 pages; 11 Figure

Biological properties of a human compact anti-ErbB2 antibody.

ErbB2 is a prognostic factor and target of therapy for many carcinomas. In contrast with the other ErbB receptors, ErbB2 lacks a soluble direct ligand, but it is the preferred co-receptor for the ErbB family members, forming heterodimers with more potent and prolonged signalling activity than that of homodimers. We recently produced a new anti-ErbB2 antibody, Erb-hcAb, by fusion of Erbicin, a human, anti-ErbB2 scFv, selectively cytotoxic to ErbB2-positive cells, and a human Fc domain. This fully human antitumour antibody represents a compact version of an IgG1, with the cytotoxicity of the scFv moiety on target cells, combined with the ability of the Fc moiety to induce both antibody- and complement-dependent cytotoxicity. Here, we describe the main properties of Erb-hcAb, using as a reference Herceptin, an anti-ErbB2 humanized monoclonal currently employed in clinical immunotherapy. We found that both bivalent Erb-hcAb and Herceptin increase receptor phosphorylation and downregulation, whereas monovalent Erbicin does not. These results correlate with the finding that Erb-hcAb is capable of inducing apoptosis and inhibiting cell cycle progression in ErbB2-positive cells. Its powerful in vitro antitumour action matched that observed in vivo in experiments with human ErbB2-positive tumour xenografts established in athymic mice. Finally, Erb-hcAb displays a glycosylation profile virtually superimposable to that of a human IgG. These findings suggest that Erb-hcAb is a very promising new agent for the immunotherapy of carcinomas that overexpress the ErbB2 receptor

Millimeter imaging of HD 163296: probing the disk structure and kinematics

We present new multi-wavelength millimeter interferometric observations of the Herbig Ae star HD 163296 obtained with the IRAM/PBI, SMA and VLA arrays both in continuum and in the 12CO, 13CO and C18O emission lines. Gas and dust properties have been obtained comparing the observations with self-consistent disk models for the dust and CO emission. The circumstellar disk is resolved both in the continuum and in CO. We find strong evidence that the circumstellar material is in Keplerian rotation around a central star of 2.6 Msun. The disk inclination with respect to the line of sight is 46+-4 deg with a position angle of 128+-4 deg. The slope of the dust opacity measured between 0.87 and 7 mm (beta=1) confirms the presence of mm/cm-size grains in the disk midplane. The dust continuum emission is asymmetric and confined inside a radius of 200 AU while the CO emission extends up to 540 AU. The comparison between dust and CO temperature indicates that CO is present only in the disk interior. Finally, we obtain an increasing depletion of CO isotopomers from 12CO to 13CO and C18O. We argue that these results support the idea that the disk of HD 163296 is strongly evolved. In particular, we suggest that there is a strong depletion of dust relative to gas outside 200 AU; this may be due to the inward migration of large bodies that form in the outer disk or to clearing of a large gap in the dust distribution by a low mass companion.Comment: Accepted for publication on A&A, 16 page

Impact of diet and nutraceutical supplementation on inflammation in elderly people. Results from the RISTOMED study, an open-label randomized control trial.

BACKGROUND & AIMS: Eating habits may influence the life span and the quality of ageing process by modulating inflammation. The RISTOMED project was developed to provide a personalized and balanced diet, enriched with or without nutraceutical compounds, to decrease and prevent inflammageing, oxidative stress and gut microbiota alteration in healthy elderly people. This paper focused on the effect on inflammation and metabolism markers after 56 days of RISTOMED diet alone or supplementation with three nutraceutical compounds. METHODS:A cohort of 125 healthy elderly subjects was recruited and randomized into 4 arms (Arm A, RISTOMED diet; Arm B, RISTOMED diet plus VSL#3 probiotic blend; Arm C, RISTOMED diet plus AISA d-Limonene; Arm D, RISTOMED diet plus Argan oil). Inflammatory and metabolism parameters as well as the ratio between Clostridium cluster IV and Bifidobacteria (CL/B) were collected before and after 56 days of dietary intervention, and their evolution compared among the arms. Moreover, participants were subdivided according to their baseline inflammatory parameters (erythrocytes sedimentation rate (ESR), C-Reactive Protein, fibrinogen, Tumor Necrosis Factor-alfa (TNF-α), and Interleukin 6) in two clusters with low or medium-high level of inflammation. The evolution of the measured parameters was then examined separately in each cluster. RESULTS:Overall, RISTOMED diet alone or with each nutraceutical supplementation significantly decreased ESR. RISTOMED diet supplemented with d-Limonene resulted in a decrease in fibrinogen, glucose, insulin levels and HOMA-IR. The most beneficial effects were observed in subjects with a medium-high inflammatory status who received RISTOMED diet with AISA d-Limonene supplementation. Moreover, RISTOMED diet associated with VSL#3 probiotic blend induced a decrease in the CL/B ratio. CONCLUSIONS:Overall, this study emphasizes the beneficial anti-inflammageing effect of RISTOMED diet supplemented with nutraceuticals to control the inflammatory status of elderly individuals