914 research outputs found
A general unified framework for pairwise comparison matrices in multicriterial methods
In a Multicriteria Decision Making context, a pairwise comparison matrix is a helpful tool to determine the weighted
ranking on a set of alternatives or criteria. The entry of the matrix can assume different meanings: can be a preference ratio (multiplicative case) or a preference difference (additive case) or belongs to and measures the
distance from the indifference that is expressed by 0.5 (fuzzy
case). For the multiplicative case, a consistency index for the
matrix has been provided by T.L. Saaty in terms of maximum eigenvalue.
We consider pairwise comparison matrices over an abelian linearly
ordered group and, in this way, we provide a general framework
including the mentioned cases. By introducing a more general notion
of metric, we provide a consistency index that has a natural
meaning and it is easy to compute in the additive and multiplicative cases; in the other cases, it can be computed easily starting from a suitable additive or multiplicative matrix
Transitive matrices, strict preference and intensity operators
Let X be a set of alternatives and a_{ij} a positive number expressing how much the alternative x_{i} is preferred to the alternative x_{j}. Under suitable hypothesis of no indifference and transitivity over the pairwise comparison matrix A= (a_{ij}), the alternatives can be ordered as a chain . Then a coherent priority vector is a vector giving a weighted ranking agreeing with the obtained chain and an intensity vector is a coherent priority vector encoding information about the intensities of the preferences. In the paper we look for operators F that, acting on the row vectors translate the matrix A in an intensity vector
A survey on pairwise comparison matrices over abelian linearly ordered groups
In this paper, we provide a survey of our results about the pairwise comparison matrices defined over
abelian linearly ordered groups
Optical properties of V2O3 in its whole phase diagram
Vanadium sesquioxide V2O3 is considered a textbook example of Mott-Hubbard
physics. In this paper we present an extended optical study of its whole
temperature/doping phase diagram as obtained by doping the pure material with
M=Cr or Ti atoms (V1-xMx)2O3. We reveal that its thermodynamically stable
metallic and insulating phases, although macroscopically equivalent, show very
different low-energy electrodynamics. The Cr and Ti doping drastically change
both the antiferromagnetic gap and the paramagnetic metallic properties. A
slight chromium content induces a mesoscopic electronic phase separation, while
the pure compound is characterized by short-lived quasiparticles at high
temperature. This study thus provides a new comprehensive scenario of the
Mott-Hubbard physics in the prototype compound V2O3
Cancer Stem Cells Sensitivity Assay (STELLA) in Patients with Advanced Lung and Colorectal Cancer: A Feasibility Study.
Cancer stem cells represent a population of immature tumor cells found in most solid tumors. Their peculiar features make them ideal models for studying drug resistance and sensitivity. In this study, we investigated whether cancer stem cells isolation and in vitro sensitivity assay are feasible in a clinical setting.
METHODS:
Cancer stem cells were isolated from effusions or fresh cancer tissue of 23 patients who progressed after standard therapy failure. Specific culture conditions selected for immature tumor cells that express markers of stemness. These cells were exposed in vitro to chemotherapeutic and targeted agents.
RESULTS:
Cancer stem cells were extracted from liver metastases in 6 cases (25%), lung nodules in 2 (8%), lymph node metastases in 3 (12.5%) and pleural/peritoneal/pericardial effusion in 13 (54%). Cancer stem cells were successfully isolated in 15 patients (63%), including 14 with lung cancer (93.3%). A sensitivity assay was successfully performed in 7 patients (30.4%), with a median of 15 drugs/combinations tested (range 5-28) and a median time required for results of 51 days (range 37-95).
CONCLUSION:
The approach used for the STELLA trial allowed isolation of cancer stem cells in a consistent proportion of patients. The low percentage of cases completing the full procedure and the long median time for obtaining results highlights the need for a more efficient procedure.
TRIAL REGISTRATION:
ClinalTrials.gov NCT01483001
A new methodological approach for road friction deterioration models development based on energetic road traffic characterization
Fondamento della Responsabilità Penale nel Diritto Internazionale: Corruzione e riciclaggio
Distinzione tra diritto penale internazionale e diritto internazionale penale; Principi di diritto penale (principio di legalità e della responsabilità personale) applicati in sede internazionale; statuto della Corte Penale Internazionale; Approfondimento dello studio sul reato transnazionale;Analisi dei delitti di corruzione e riciclaggio nell'ambito della Convenzione di Palermo delle Nazioni Unit
Simplified approach to integrate seismic retrofitting prioritization with social cost evaluation: A case study in central Italy
In the last three decades, bridge stock seismic retrofitting prioritization has become one of the cult topics for scientific discussions in the bridge management strategies. More recent methods are focusing on the evaluation of the generalized failure cost, of a specific bridge derived from direct and indirect costs induced to the users/residents of the area exposed to the seismic hazard as a consequence of bridge collapse. However, when these approaches have to be applied to large transport networks, appear still very complex and computa-tional demanding, and therefore simplified methods to evaluate the impact in terms of social cost related to the reduced efficiency of a transportation network due to potential bridge failure, are required.In this work, a simplified method for seismic retrofitting prioritization on a bridge stock is proposed, which is based on a "blended" approach considering specific fragility curves according to several bridge features and condition state, seismic inputs and generalized failure costs related to the transportation network. The effectiveness of the method has been showed on a case study of a local bridge stock placed in central Italy and the obtained results have been compared with those provided by more refined transport simulation models, on one hand, and by more traditional prioritization approaches, on the other. It is highlighted that this method can be very useful for transportation network managers with in a limited budget scenario, in case of lack of information about possible earthquake -induced impacts on a transportation network efficiency.(c) 2022 Periodical Offices of Chang'an University. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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