Does interpreter-mediated CBT with traumatized refugee people work? A comparison of patient outcomes in East London

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An Analysis of Early Renal Transplant Protocol Biopsies - the High Incidence of Subclinical Tubulitis

To investigate the possibility that we have been underestimating the true incidence of acute rejection, we began to perform protocol biopsies after kidney transplantation. This analysis looks at the one-week biopsies. Between March 1 and October 1, 1999, 100 adult patients undergoing cadaveric kidney or kidney/pancreas transplantation, or living donor kidney transplantation, underwent 277 biopsies. We focused on the subset of biopsies in patients without delayed graft function (DGF) and with stable or improving renal function, who underwent a biopsy 8.2 ± 2.6 d (range 3-18 d) after transplantation (n = 28). Six (21%) patients with no DGF and with stable or Improving renal function had borderline histopathology, and 7 (25%) had acute tubulitis on the one-week biopsy. Of the 277 kidney biopsies, there was one (0.4%) serious hemorrhagic complication, in a patient receiving low molecular weight heparin; she ultimately recovered and has normal renal function. Her biopsy showed Banff 1B tubulitis. In patients with stable or improving renal allograft function early after transplantation, subclinical tubulitis may be present in a substantial number of patients. This suggests that the true incidence of rejection may be higher than is clinically appreciated

Human substantia nigra and ventral tegmental area involvement in computing social error signals during the ultimatum game

Social norms play an essential role in our societies, and since the social environment is changing constantly, our internal models of it also need to change. In humans, there is mounting evidence that neural structures such as the insula and the ventral striatum are involved in detecting norm violation and updating internal models. However, because of methodological challenges, little is known about the possible involvement of midbrain structures in detecting norm violation and updating internal models of our norms. Here we used high-resolution cardiac-gated functional magnetic resonance imaging and a norm adaptation paradigm in healthy adults to investigate the role of the substantia nigra/ventral tegmental area (SN/VTA) complex in tracking signals related to norm violation that can be used to update internal norms. We show that the SN/VTA codes for the norm's variance prediction error (PE) and norm PE with spatially distinct regions coding for negative and positive norm PE. These results point to a common role played by the SN/VTA complex in supporting both simple reward-based and social decision making

Asymmetry in functional connectivity of the human habenula revealed by high-resolution cardiac-gated resting state imaging

The habenula is a hub for cognitive and emotional signals that are relayed to the aminergic centers in the midbrain and, thus, plays an important role in goal-oriented behaviors. Although it is well described in rodents and non-human primates, the habenula functional network remains relatively uncharacterized in humans, partly because of the methodological challenges associated with the functional magnetic resonance imaging of small structures in the brain. Using high-resolution cardiac-gated resting state imaging in healthy humans and precisely identifying each participants' habenula, we show that the habenula is functionally coupled with the insula, parahippocampus, thalamus, periaqueductal grey, pons, striatum and substantia nigra/ventral tegmental area complex. Furthermore, by separately examining and comparing the functional maps from the left and right habenula, we provide the first evidence of an asymmetry in the functional connectivity of the habenula in humans. Hum Brain Mapp 37:2602-2615, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc

Studies of epithermal neutrons in uranium, heavy water lattices

Statement of responsibility on title-page reads: W. H. D'Ardenne, T. J. Thompson, D. D. Lanning and I. Kaplan"August 24, 1964.""MIT-2344-2."Also issued as a Ph. D. thesis by the first author, MIT Dept. of Nuclear Engineering, 1964Includes bibliographical references (leaves 167-170)Measurements related to reactor physics parameters were made in three heavy water lattices. The three lattices studied consisted of 0.250-inch-diameter, 1.03 w/o U2 3 5 uranium fuel rods arranged in triangular arrays and spaced at 1.25, 1.75, and 2.50 inches. The following quantities were measured in each of the three lattices studied: the ratio of the average epicadmium U2 3 8 capture rate in the fuel rod to the average subcadmium U2 3 8 capture rate in the fuel rod ([sigma]28); the ratio of the average epicadmium U2 3 o fission rate in the fuel rod7 to the average subcadmium U 35 fission rate in the fuel rod (625); the ratio of the average U2 3 8 capture rate in the fuel rod to the average U2 3 5 fission rate in the fuel rod (C ); the ratio of the average U2 3 8 fission rate in the fuel rod to the average U2 3 5 fission rate in the fuel rod (628); and the effective resonance integral of U2 3 8 in a fuel rod (ER12 8 ).The results of an investigation of systematic errors associated with these measurements have-led to many changes and adjustments in the experimental techniques and procedure which have improved the general precision of the experimental results. A new method was developed to measure the ratio C * which simplified the experiment, significantly reduced the experimental uncertainty associated with the measurement, and avoided systematic errors inherent in the method used to measure C* in earlier work. The value of ER12 8 was also measured by a new method in which the results of measurements made in an epithermal flux which had a 1/E energy dependence are combined with the results of measurements made in a lattice.The experimental results were combined with theoretical results obtained from the computer programs THERMOS and GAM-I to determine the following reactor physics parameters for each of the three lattices studied: the resonance escape probability, p; the fast fission factor, E; the multiplication factor for an infinite system, k [infinity]; and the initial conversion ratio, C. Methods were developed to measure that portion of the activity of a foil which is due to neutron captures in the resonances in the activation cross section of the foil material. The resonance escape probability was determined by a new method, using the resonance activation date, in which the use of cadmium is not necessary.U.S. Atomic Energy Commission contract AT(30-1)-234

The Development of a Research Programme to Translate and Test the Personal Well-being Questions in Sylheti and Urdu

A pilot research programme was undertaken in order to translate and cognitively test the personal well-being questions developed by the Office for National Statistics (ONS) in the UK into Urdu and Sylheti. These are both complex languages spoken by minority ethnic groups in the UK; monolingual speakers of these languages have been identified as being at risk of lower general health, and thus potentially of a lower well-being than the general UK population. The research programme involved two key stages in the production of these translations: translation workshops and cognitive testing of the translations. The translation workshops brought together experts in questionnaire development and personal well-being with native speakers of the languages from the community and bilingual interviewers in order to attempt to underpin the essence of the four personal well-being measures and arrive at the translation to be tested. The cognitive interviews that followed assessed these translations and the level of appropriateness of these measures with monolingual speakers in the UK. This article discusses the merits of each stage of this research programme in arriving at the best and most suitable translation for the personal well-being questions in Sylheti and Urdu

Comparison of the solophenyl-red polarization method and the immunohistochemical analysis for collagen type III

In the present study, we have compared the staining pattern of the Solophenyl-Red 3 BL-method for the visualization of collagen type III with the immunohistochemical staining in serial sections from 7 skin wounds (wound age 3 days up to 4 weeks) to elucidate the specifity of the histochemical staining method. Large amounts of collagen type III were clearly detectable in the investigated wounds using the immunohistochemical technique. In the sections stained with Solophenyl-Red, however, only 3 out of 7 skin lesions showed a significant positive red staining at the wound margin or in the granulation tissue, while the adjacent normal connective tissue revealed a typical intensive staining. Using polarization microscopy no characteristic bright green fibrils, as reported for collagen type 111, could be seen in the wound areas without positive Solophenyl-Red staining. Since the localization of collagen type III detected by immunohistochemistry and the presumed distribution of this collagen type by the Solophenyl-Red method was not identical, the histochemical polarization method has to be regarded as non-specific for visualization of this collagen type

Understanding Society Innovation Panel Wave 6: results from methodological experiments

This paper presents some preliminary findings from Wave 6 of the Innovation Panel (IP6) of Understanding Society: The UK Household Longitudinal Study. Understanding Society is a major panel survey in the UK. In March 2013, the sixth wave of the Innovation Panel went into the field. IP6 used a mixed-mode design, using on-line interviews and face-to-face interviews. This paper describes the design of IP6, the experiments carried and the preliminary findings from early analysis of the data