The GiSAS study: Rationale and design of pragmatic randomized controlled trial on aripiprazole, olanzapine and haloperidol in the long-term treatment of schizophrenia

Given the controversy about the comparative efficacy of first- compared with second-generation antipsychotics in the treatment of schizophrenia, more large-scale evidence is needed to guide clinicians in their prescriptions. Most randomized controlled trials (RCTs) were conducted in centers of excellence on highly selected samples, poorly representative of real-world patients, and often suffered conflicts of interest as they were sponsored by drug companies. The primary aim of the present study is to compare the effectiveness of haloperidol, olanzapine and aripiprazole in a representative sample of schizophrenia patients. The GiSAS trial is an open-label, independent, pragmatic RCT in Italian community-based public psychiatric services. At least 260 patients meeting the DSM-IV criteria for schizophrenia will be randomly allocated to one of the study drugs and followed up for one year. A two-year observational phase will follow. The primary outcome for tolerability will be the onset of metabolic syndrome. The primary endpoint for effectiveness will be discontinuation of antipsychotic monotherapy. Secondary measures include global functioning, time to discontinuation due to side-effects, change of lipid profile, extrapyramidal symptoms and other adverse effects. In the last four years, the GiSAS study group has been working to implement this multicenter RCT. The trial mechanism is now fully functional and working. As of end of February 2011, 260 subjects were randomized by 54 study investigators in 33 out of 43 participating centers

There is a short gamma-ray burst prompt phase at the beginning of each long one

We compare the prompt intrinsic spectral properties of a sample of short Gamma--ray Burst (GRB) with the first 0.3 seconds (rest frame) of long GRBs observed by Fermi/GBM. We find that short GRBs and the first part of long GRBs lie on the same E_p--E_iso correlation, that is parallel to the relation for the time averaged spectra of long GRBs. Moreover, they are indistinguishable in the E_p--L_iso plane. This suggests that the emission mechanism is the same for short and for the beginning of long events, and both short and long GRBs are very similar phenomena, occurring on different timescales. If the central engine of a long GRB would stop after ~0.3 * (1+z) seconds the resulting event would be spectrally indistinguishable from a short GRB.Comment: 14 pages, 6 figures, MNRAS accepte

On the offset of Short Gamma-ray Bursts

Short Gamma-Ray Bursts (SGRBs) are expected to form from the coalescence of compact binaries, either of primordial origin or from dynamical interactions in globular clusters. In this paper, we investigate the possibility that the offset and afterglow brightness of a SGRB can help revealing the origin of its progenitor binary. We find that a SGRB is likely to result from the primordial channel if it is observed within 10 kpc from the center of a massive galaxy and shows a detectable afterglow. The same conclusion holds if it is 100 kpc away from a small, isolated galaxy and shows a weak afterglow. On the other hand, a dynamical origin is suggested for those SGRBs with observable afterglow either at a large separation from a massive, isolated galaxy or with an offset of 10-100 kpc from a small, isolated galaxy. We discuss the possibility that SGRBs from the dynamical channel are hosted in intra-cluster globular clusters and find that GRB 061201 may fall within this scenario.Comment: 5 pages, 3 figures, MNRAS in pres

GRB 081029: Understanding Multiple Afterglow Components

We present an analysis of the unusual optical light curve of the gamma-ray burst GRB~081029, which occurred at a redshift of z = 3.8479$. We combine X-ray and optical observations from the Swift X-Ray Telescope and the Swift UltraViolet/Optical Telescope with optical and infrared data obtained using the REM and ROTSE telescopes to construct a detailed data set extending from 86 s to approximately 100,000 s after the BAT trigger. Our data also cover a wide energy range, from 10 keV to 0.77 eV (1.24 Angstrom to 16,000 Angstrom). The X-ray afterglow shows a shallow initial decay followed by a rapid decay starting at about 18,000s. The optical and infrared afterglow, however, shows an uncharacteristic rise at about 5000 s that does not correspond to any feature in the X-ray light curve. Our data are not consistent with synchrotron radiation from a single-component jet interacting with an external medium. We do, however, find that the observed light curve can be explained using multi-component model for the jet.Comment: 4 pages, 3 figures, to appear in the AIP Conference Proceedings for the Gamma-Ray Burst 2010 Conference, Annapolis, MD, USA, November 201

A complete sample of bright Swift Long Gamma Ray Bursts: testing the spectral-energy correlations

We use a nearly complete sample of Gamma Ray Bursts (GRBs) detected by the Swift satellite to study the correlations between the spectral peak energy Ep of the prompt emission, the isotropic energetics Eiso and the isotropic luminosity Liso. This GRB sample is characterized by a high level of completeness in redshift (90%). This allows us to probe in an unbiased way the issue related to the physical origin of these correlations against selection effects. We find that one burst, GRB 061021, is an outlier to the Ep-Eiso correlation. Despite this case, we find strong Ep-Eiso and Ep-Liso correlations for the bursts of the complete sample. Their slopes, normalisations and dispersions are consistent with those found with the whole sample of bursts with measured redshift and Ep. This means that the biases present in the total sample commonly used to study these correlations do not affect their properties. Finally, we also find no evolution with redshift of the Ep-Eiso and Ep-Liso correlations.Comment: MNRAS in press, 9 pages, 4 figures, 2 tables. This version matches the published version in MNRA

Optical and X-ray Rest-frame Light Curves of the BAT6 sample

We present the rest-frame light curves in the optical and X-ray bands of an unbiased and complete sample of Swift long Gamma-Ray Bursts (GRBs), namely the BAT6 sample. The unbiased BAT6 sample (consisting of 58 events) has the highest level of completeness in redshift ($\sim$ 95%), allowing us to compute the rest-frame X-ray and optical light curves for 55 and 47 objects, respectively. We compute the X-ray and optical luminosities accounting for any possible source of absorption (Galactic and intrinsic) that could affect the observed fluxes in these two bands. We compare the behaviour observed in the X-ray and in the optical bands to assess the relative contribution of the emission during the prompt and afterglow phases. We unarguably demonstrate that the GRBs rest-frame optical luminosity distribution is not bimodal, being rather clustered around the mean value Log(L$_{R}$) = 29.9 $\pm$ 0.8 when estimated at a rest frame time of 12 hr. This is in contrast with what found in previous works and confirms that the GRB population has an intrinsic unimodal luminosity distribution. For more than 70% of the events the rest-frame light curves in the X-ray and optical bands have a different evolution, indicating distinct emitting regions and/or mechanisms. The X-ray light curves normalised to the GRB isotropic energy (E$_{\rm iso}$), provide evidence for X-ray emission still powered by the prompt emission until late times ($\sim$ hours after the burst event). On the other hand, the same test performed for the E$_{\rm iso}$-normalised optical light curves shows that the optical emission is a better proxy of the afterglow emission from early to late times.Comment: Accepted for publication in A&A: 10 pages, 5 figures, 2 table

Searching for supergiant fast X-ray transients with Swift

Supergiant fast X-ray transients (SFXTs) are high mass X-ray binaries (HMXBs) hosting a neutron star and an OB supergiant companion. We examine the available Swift data, as well as other new or archival/serendipitous data, on three sources: IGR J17407-2808, 2XMM J185114.3-000004, and IGR J18175-2419, whose X-ray characteristics qualify them as candidate SFXT, in order to explore their properties and test whether they are consistent with an SFXT nature. As IGR J17407-2808 and 2XMM J185114.3-000004 triggered the Burst Alert Telescope on board Swift, the Swift data allow us to provide their first arcsecond localisations, leading to an unequivocal identification of the source CXOU J174042.0-280724 as the soft X-ray counterpart of IGR J17407-2808, as well as their first broadband spectra, which can be fit with models generally describing accreting neutron stars in HMXBs. While still lacking optical spectroscopy to assess the spectral type of the companion, we propose 2XMM J185114.3-000004 as a very strong SFXT candidate. The nature of IGR J17407-2808 remains, instead, more uncertain. Its broad band properties cannot exclude that the emission originates from either a HMXB (and in that case, a SFXT) or, more likely, a low mass X-ray binary. Finally, based on the deep non-detection in our XRT monitoring campaign and a careful reanalysis of the original Integral data in which the discovery of the source was first reported, we show that IGR J18175-2419 is likely a spurious detection.Comment: Accepted for publication in Astronomy and Astrophysics. 12 pages, 11 figures, 6 table

A magnetar powering the ordinary monster GRB 130427A?

We present the analysis of the extraordinarily bright Gamma-Ray Burst (GRB) 130427A under the hypothesis that the GRB central engine is an accretion-powered magnetar. In this framework, initially proposed to explain GRBs with precursor activity, the prompt emission is produced by accretion of matter onto a newly-born magnetar, and the observed power is related to the accretion rate. The emission is eventually halted if the centrifugal forces are able to pause accretion. We show that the X-ray and optical afterglow is well explained as the forward shock emission with a jet break plus a contribution from the spin-down of the magnetar. Our modelling does not require any contribution from the reverse shock, that may still influence the afterglow light curve at radio and mm frequencies, or in the optical at early times. We derive the magnetic field ($B\sim 10^{16}$ G) and the spin period ($P\sim 20$ ms) of the magnetar and obtain an independent estimate of the minimum luminosity for accretion. This minimum luminosity results well below the prompt emission luminosity of GRB 130427A, providing a strong consistency check for the scenario where the entire prompt emission is the result of continuous accretion onto the magnetar. This is in agreement with the relatively long spin period of the magnetar. GRB 130427A was a well monitored GRB showing a very standard behavior and, thus, is a well-suited benchmark to show that an accretion-powered magnetar gives a unique view of the properties of long GRBs.Comment: 5 pages, 1 figure, accepted for publication in MNRAS Letter

Studies of Quasi Periodic Oscillations in the Black Hole Transient XTE J 1817-330

We have used archival RXTE PCA data to investigate timing and spectral characteristics of the transient XTE J1817-330. The data pertains to 160 PCA pointed observations made during the outburst period 2006, January 27 to August 2. A detailed analysis of Quasi-Periodic Oscillations (QPOs) in this black hole X-ray binary is carried out. Power density spectra were obtained using the light curves of the source. QPOs have been detected in the 2-8 keV band in 10 of the observations. In 8 of these observations, QPOs are present in the 8-14 keV and in 5 observations in the 15-25 keV band. XTE J1817-330 is the third black hole source from which the low frequency QPOs are clearly detected in hard X-rays. The QPO frequency lies in ~ 4-9 Hz and the rms amplitude in 1.7-13.3% range, the amplitude being higher at higher energies. We have fitted the PDS of the observations with Lorentzian and power law models. Energy spectra are derived for those observations in which the QPOs are detected to investigate any dependence of the QPO characteristic on the spectral parameters. These spectra are well fitted with a two component model that includes the disk black body component and a power law component. The QPO characteristics and their variations are discussed and its implication on the origin of the QPOs are examinedComment: 16 page, 9 figures and 2 tables. Accepted in MNRAS Journa

Dust extinction for an unbiased sample of GRB afterglows

In this paper we compute rest-frame extinctions for the afterglows of a sample of gamma-ray bursts complete in redshift. The selection criteria of the sample are based on observational high-energy parameters of the prompt emission and therefore our sample should not be biased against dusty sight-lines. It is therefore expected that our inferences hold for the general population of gamma-ray bursts. Our main result is that the optical/near-infrared extinction of gamma-ray burst afterglows in our sample does not follow a single distribution. 87% of the events are absorbed by less than 2 mag, and 50% suffer from less than 0.3-0.4 mag extinction. The remaining 13% of the afterglows are highly absorbed. The true percentage of gamma-ray burst afterglows showing high absorption could be even higher since a fair fraction of the events without reliable redshift measurement are probably part of this class. These events may be due to highly dusty molecular clouds/star forming regions associated with the gamma-ray burst progenitor or along the afterglow line of sight, and/or to massive dusty host galaxies. No clear evolution in the dust extinction properties is evident within the redshift range of our sample, although the largest extinctions are at z~1.5-2, close to the expected peak of the star formation rate. Those events classified as dark are characterized, on average, by a higher extinction than typical events in the sample. A correlation between optical/near-infrared extinction and hydrogen-equivalent column density based on X-ray studies is shown although the observed NH appears to be well in excess compared to those observed in the Local Group. Dust extinction does not seem to correlate with GRB energetics or luminosity.Comment: 18 pages, 7 figures, 10 tables, MNRAS, in pres