Pessimism of the Intellect, Optimism of the Will: Reading the Ideas and Ideals of the New Student Left

Scholarships & Prizes Office. University of Sydne

Let the Lunatics Run their Own Asylum Participatory Democracy at the University of Sydney, 1960–1979

Participatory democracy lay at the heart of the student movements that erupted around the world in the 1960s. ‘Let the Lunatics Run their Own Asylum’ seeks to understand this defining aspect of student movements through an exploration of a democratic ‘break-out’ that occurred at the University of Sydney in the early 1970s. The nature of participatory democracy will be examined, both as the movement’s mode of organisation, as well as being the principal demand that the movement placed on the university to open up its hierarchical system of governance. It focuses on the ‘feminist strike’, which occurred in 1973, and the subsequent division of the Philosophy Department into the Department of Traditional and Modern Philosophy, and the Department of General Philosophy. It concludes with an examination of the latter, which operated according to a democratic constitution until 1979. This thesis explores the rise and fall of this democratic moment; its causes, significance and its ultimate collapse

Pessimism of the Intellect, Optimism of the Will: Reading the Ideas and Ideals of the New Student Left

Scholarships & Prizes Office. University of Sydne

Differential gene expression in HCV liver injury

Chronic hepatitis C virus (HCV) infection causes liver disease that can lead to cirrhosis and hepatocellular carcinoma (HCC). The predominant HCV genotypes in Australia (G1 and G3) differ in the pathogenesis of liver injury and treatment response, but the molecular mechanisms are not well defined. The aim of this research is to determine specific HCV genotype differences in the global mRNA and miRNA expression associated with HCV induced liver injury. The mRNA transcriptome and miRNA expression of HCV induced liver injury (G1 or G3) was characterised in progressive liver injury, advanced cirrhosis from individuals with and without HCC compared with non diseased liver using Illumina Whole genome BeadChip Arrays and Taqman Low Density Arrays. Further, the mRNA expression of HCV genotype-specific core chimeric JFH1 infected Huh 7 cells following lipid loading was similarly characterised. In progressive liver injury, HCV genotype is associated with the greatest variation in gene expression between individuals. There is increased expression of interferon stimulated genes, inflammation and fibrosis genes in G3, and increased expression of fatty acid degradation and cholesterol transport associated genes in G1. In advanced cirrhosis, the cirrhotic gene signature masks the genotype specific gene expression patterns. No gene signature distinguishes cirrhotic liver injury from individuals with and without HCC. The miRNA expression is associated with the severity of disease with no HCV genotype specific differences identified. The mRNA transcriptome of a hepatic cell line infected with chimeric HCV specific for the HCV core protein is consistent with the in vivo analysis with increased expression of genes associated with fibrosis and proliferation in G3, but no differences were observed in fatty acid metabolism. In conclusion, the HCV genotype specific differences in gene expression are more defined in progressive liver injury compared with changes seen in advanced cirrhosis