Shaping the formation of university-industry research collaborations: what type of proximity does really matter?

Research collaborations between universities and industry (U-I) are considered to be one important channel of potential localised knowledge spillovers. These collaborations favour both intended and unintended flows of knowledge and facilitate learning processes between partners from different organisations. Despite the copious literature on localised knowledge spillovers, still little is known about the factors driving the formation of U-I research collaborations and, in particular, about the role that geographical proximity plays in the establishment of such relationships. Using collaborative research grants between universities and business firms awarded by the UK Engineering and Physical Sciences Research Council (EPSRC), in this paper we disentangle some of the conditions under which different kinds of proximity contribute to the formation of U-I research collaborations, focussing in particular on technological complementarity among the firms participating in such partnerships.university-industry research collaborations, proximity, geography, industrial clustering, technological complementarity

Capitale economico e fair value. Analogie e differenze concettuali nella determinazione e rappresentazione del valore generato dalle aziende

Il presente lavoro si propone di esaminare gli aspetti della determinazione del valore generato dalle aziende, correlati ai presupposti logici propri delle differenti metodologie di valutazione del capitale di impresa, con particolare attenzione al concetto di valore economico ed a quello di fair value. L’indagine di affinità e divergenze esistenti tra questi ultimi, in merito ad impostazioni logiche e significatività dei risultati, ha posto in evidenza gli ostacoli concettuali ad una puntuale traduzione in termini operativi di entrambi, rinvenendo nel comprehensive income una possibile soluzione alla rappresentazione contabile delle differenti forme di determinazione del reddito secondo tali logiche valutative.valore economico, fair value, capitale economico, comprehensive income

What hampers innovation? Evidence from the UK CIS4

barriers to innovation, innovative firms, non-innovators

Academic Entrepreneurship: What are the Factors Shaping the Capacity of Academic Researchers to Identify and Exploit Entrepreneurial Opportunities?

This paper aims at improving our understanding of the attributes of academic researchers that influence the capacity to identify and exploit entrepreneurial opportunities. We investigate a number of factors highlighted in the literature as influencing the entrepreneurial activities undertaken by academics. Our results show that identification and exploitation of entrepreneurial opportunities are shaped by different factors. While identification of commercial opportunities is driven by prior entrepreneurial experience and the excellence of the academic work, exploitation of entrepreneurial opportunities is driven by the extent of previous collaboration with industry partners, cognitive integration and prior entrepreneurial experience.Academic entrepreneurship; Opportunity identification; Opportunity exploitation; Spin-offs; Patenting; University-business collaboration

Supporting Policy In health with Research: an Intervention Trial (SPIRIT)-protocol for a stepped wedge trial

Introduction: Governments in different countries have committed to better use of evidence from research in policy. Although many programmes are directed at assisting agencies to better use research, there have been few tests of the effectiveness of such programmes. This paper describes the protocol for SPIRIT (Supporting Policy In health with Research: an Intervention Trial), a trial designed to test the effectiveness of a multifaceted programme to build organisational capacity for the use of research evidence in policy and programme development. The primary aim is to determine whether SPIRIT results in an increase in the extent to which research and research expertise is sought, appraised, generated and used in the development of specific policy products produced by health policy agencies. Methods and analysis: A stepped wedge cluster randomised trial involving six health policy agencies located in Sydney, Australia. Policy agencies are the unit of randomisation and intervention. Agencies were randomly allocated to one of three start dates (steps) to receive the 1-year intervention programme, underpinned by an action framework. The SPIRIT intervention is tailored to suit the interests and needs of each agency and includes audit, feedback and goal setting; a leadership programme; staff training; the opportunity to test systems to assist in the use of research in policies; and exchange with researchers. Outcome measures will be collected at each agency every 6 months for 30 months (starting at the beginning of step 1). Ethics and dissemination: Ethics approval was granted by the University of Western Sydney Human Research and Ethics Committee HREC Approval H8855. The findings of this study will be disseminated broadly through peer-reviewed publications and presentations at conferences and used to inform future strategies

Simultaneous embeddedness in different networks and its effect on scientific knowledge generation: evidence from Spanish scientists

Trabajo presentado a la EU-SPRI Conference: "Science and Innovation Policy: Dynamics, Challenges, Responsibility and Practice", celebrada en Manchester (UK) del 18 al 20 de junio de 2014.Introduction: research topic Interactions between Public Research Organisations (PROs henceforth) and Industry are at the forefront of policy agendas world-wide as they are instrumental to foster technological development and economic competitiveness. Interactions between PROs and industry can also help attenuate the pressures that the current global economic crisis place on public sector research budgets - especially in countries with high levels of debt -by providing external private funding, directly oriented to the generation of marketable innovations. The scope of this paper is to deepen the understanding of PROs-Industry links with reference to the antecedents of their formation and the impact of these links on the world of scientific knowledge production. In broad terms this endeavour involves the analysis of the process through which knowledge producers (i.e. scientists) both organize within their own community and interact with industry to generate scientific knowledge.Peer Reviewe

Bio-sample environment manipulation using advanced microscopy techniques

2010/2011Under physiological conditions in the brain, molecules are released with high spatial and temporal resolution. A lot of efforts have been done in the last years in order to develop techniques that mimic this situation. Among them, we mention the use of micropipettes for the ejection of fluids, the use of AFM (Atomic Force Microscopy), microfluidic devices and optical manipulation. The latter approach exploits light to manipulate the samples, e.g. to create transient pores in the cell membrane or to move small objects carrying a stimulus. This Thesis concerns with the development of new techniques for the local delivery of molecules based on optical manipulation technologies, and in particular on optical tweezers. Sub-micrometer particles in a compact trap, such as the single-beam gradient or optical tweezers, can be localized within a small fraction of a wavelength of light or moved over long distances of many centimeters without any mechanical contact. A three-dimensional trap is simply created by focusing a laser beam through a microscope objective with high numerical aperture. We studied three types of vectors for local delivery of molecules, which can be optically manipulated: microbeads, micron-sized liposomes and Quantum dots (Qdots). Silica microbeads can be covalently functionalized on their surface with the protein of interest and placed in contact with the desired part of a cell. In order to validate the technique, we functionalized beads with a secretory molecule, the neurotrophin Brain-derived neurotrophic factor (BDNF). BDNF is a key regulator of neuronal development and plasticity. We showed that single BDNF-coated microbeads can be extracted with optical tweezers from small reservoirs and positioned with submicrometric precision to specific sites on the dendrites of cultured hippocampal neurons. Localized contact of microbeads functionalized with BDNF induced focal increase of Calcium signaling in the stimulated dendrite, specific activation of the TrkB receptor pathway and influenced the development of growth cones. Remarkably, a single BDNF-coated bead positioned on a dendrite was found to be enough for TrkB phosphorylation, an efficient and long-lasting activation of Calcium signaling in the soma, and c-Fos signaling in the nucleus, comparable to bath stimulation conditions. Moreover, since BDNF is covalently cross-linked to the bead surface we could demonstrate that activation of some of the TrkB receptor pathway does not necessarily require BDNF endocytosis. In the case of liposomes, the molecules of interest were encapsulated within their lumen. Single liposomes were trapped and transported by means of optical tweezers to the site of stimulation on cultured neurons. Finally, the release of liposome content was induced by application of UV-pulses that broke the liposome membrane. In order to test the effect of the UV-induced release, liposomes with a diameter ranging from 1 to 10 μm (fL to pL volumes), were filled with KCl and tested on neuronal cells. Neuronal cultures, loaded with Ca2+ dye, were monitored by imaging intracellular Ca2+. An efficient release from the liposomes was demonstrated by detectable Calcium signals, indicating induced depolarization of the neuronal cells by KCl. Afterwards, this technique was used to address a biological issue, that is the effect of two proteins (Semaphorin 3A and Netrin-1) on growth cones. The growth cone is an intracellular apparatus located at the tip of the neurite of developing neurons. Its motility governs axonal path-finding and the construction of neuronal networks. Growth cones are highly dynamic structures that respond to external stimuli turning towards or away from the chemical gradient. We were able to demonstrate an attractive effect of Netrin-1 on the growth cones of primary hippocampal neurons. On the contrary, Semaphorin 3A showed a repellant behavior. To correlate the high resolution of vector manipulation with high resolution of imaging we used STimulated Emission Depletion (STED) to investigate the intimate organization of two main cytoskeleton components: actin and tubulin filaments. STED microscopy allowed imaging of actin bundles in the filopodia and organized network in lamellipodia with un-precedent resolution, beyond the diffraction barrier. Lastly, we used liposomes to encapsulate Quantum dots. Qdots are bright and photostable nanocrystals. Due to their small size, similar to that of proteins, Qdots may be endocyted along the receptor-mediated endocytosis pathway, when they are functionalized with the appropriate ligand. As case study we considered the BDNF-TrkB endocytotic pathway. We optimized the protocol for the direct binding of BDNF to Qdots and we demonstrated the possibility of encapsulating and releasing them from liposomes. Concluding, two different approaches for local stimulation of neurons, based on optical manipulation of microvectors, were presented and validated in this thesis. Indirect optical manipulation of nanovectors (Qdots) encapsulated in liposomes has been demonstrated as well. The techniques were then successfully applied to address some biological issues, that in turn required the optimization of other imaging tools (super resolution microscopy and Qdots).XXIV Ciclo198