609 research outputs found
Sommerfeld's quantum condition of action and the spectra of Schwarzschild black hole
If the situation of quantum gravity nowadays is nearly the same as that of
the quantum mechanics in it's early time of Bohr and Sommerfeld, then a first
step study of the quantum gravity from Sommerfeld's quantum condition of action
might be helpful. In this short paper the spectra of Schwarzschild black
hole(SBH) in quasi-classical approach of quantum mechanics is given. We find
the quantum of area, the quantum of entropy and the Hawking evaporation will
cease as the black hole reaches its ground state.Comment: 7 pages, no figures, submitted to Classical and Quantum Gravit
The Opportunity Prior: A Simple and Practical Solution to the Prior Probability Problem for Legal Cases
One of the greatest impediments to the use of probabilistic reasoning in legal arguments is the difficulty in agreeing on an appropriate prior probability for the ultimate hypothesis, (in criminal cases this is normally “Defendant is guilty of the crime for which he/she is accused”). Even strong supporters of a Bayesian approach prefer to ignore priors and focus instead on considering only the likelihood ratio (LR) of the evidence. But the LR still requires the decision maker (be it a judge or juror during trial, or anybody helping to determine beforehand whether a case should proceed to trial) to consider their own prior; without it the LR has limited value. We show that, in a large class of cases, it is possible to arrive at a realistic prior that is also as consistent as possible with the legal notion of ‘innocent until proven guilty’. The approach can be considered as a formalisation of the ‘island problem’ whereby if it is known the crime took place on an island when n people were present, then each of the people on the island has an equal prior probability 1/n of having carried out the crime. Our prior is based on simple location and time parameters that determine both a) the crime scene/time (within which it is certain the crime took place) and b) the extended crime scene/time which is the ‘smallest’ within which it is certain the suspect was known to have been ‘closest’ in location/time to the crime scene. The method applies to cases where we assume a crime has taken place and that it was committed by one person against one other person (e.g. murder, assault, robbery). The paper considers both the practical and legal implications of the approach. We demonstrate how the opportunity prior probability is naturally incorporated into a generic Bayesian network model that allows us to integrate other evidence about the case
Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization
Latent force models for sound: Learning modal synthesis parameters and excitation functions from audio recordings
Latent force models are a Bayesian learning technique that combine physical knowledge with dimensionality reduction - sets of coupled differential equations are modelled via shared dependence on a low-dimensional latent space. Analogously, modal sound synthesis is a technique that links physical knowledge about the vibration of objects to acoustic phenomena that can be observed in data. We apply latent force modelling to sinusoidal models of audio recordings, simultaneously inferring modal synthesis parameters (stiffness and damping) and the excitation or contact force required to reproduce the behaviour of the observed vibrational modes. Exposing this latent excitation function to the user constitutes a controllable synthesis method that runs in real time and enables sound morphing through interpolation of learnt parameters
Recommendations for core critical care ultrasound competencies as a part of specialist training in multidisciplinary intensive care: a framework proposed by the European Society of Intensive Care Medicine (ESICM)
© 2020 The Author(s). Critical care ultrasound (CCUS) is an essential component of intensive care practice. Although existing international guidelines have focused on training principles and determining competency in CCUS, few countries have managed to operationalize this guidance into an accessible, well-structured programme for clinicians training in multidisciplinary intensive care. We seek to update and reaffirm appropriate CCUS scope so that it may be integrated into the international Competency-based Training in Intensive Care Medicine. The resulting recommendations offer the most contemporary and evolved set of core CCUS competencies for an intensive care clinician yet described. Importantly, we discuss the rationale for inclusion but also exclusion of competencies listed. Background/aim: Critical care ultrasound (CCUS) is an essential component of intensive care practice. The purpose of this consensus document is to determine those CCUS competencies that should be a mandatory part of training in multidisciplinary intensive care. Methods: A three-round Delphi method followed by face-to-face meeting among 32 CCUS experts nominated by the European Society of Intensive Care Medicine. Agreement of at least 90% of experts was needed in order to enlist a competency as mandatory. Results: The final list of competencies includes 15 echocardiographic, 5 thoracic, 4 abdominal, deep vein thrombosis diagnosis and central venous access aid. Conclusion: The resulting recommendations offer the most contemporary and evolved set of core CCUS competencies for an intensive care clinician yet described
Interim Guidance for Basic and Advanced Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With the Guidelines®-Resuscitation Adult and Pediatric Task Forces of the American Heart Association in Collaboration with the American Academy of Pediatrics, American Association for Respiratory Care, American College of Emergency Physicians, The Society of Critical Care Anesthesiologists, and American Society of Anesthesiologists: Supporting Organizations: American Association of Critical Care Nurses and National EMS Physicians.
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