9,470 research outputs found

    High School Inputs and Labor Market Outcomes for Male Workers in Their Mid-Thirties: New Data and New Estimates from Wisconsin

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    This study presents new evidence on the relationship between high school inputs measured at the time male respondents attended high school and the earnings of these same individuals when they were in their mid-thirties. To accomplish this task, we matched newly coded data on the characteristics of Wisconsin high schools in 1954–57 to the Wisconsin Longitudinal Survey. Our estimates show a significant relationship between the characteristics of teachers and the earnings of their students 17 years after graduation. Specifically, a 1 percent increase in the average teacher salary in a district increases the earnings of students by 0.33 percent. The magnitude of this effect is larger than estimates reported in previous research and many times larger than the impact of increasing parents’ income by a comparable amount.

    Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in C. elegans

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    Iron plays an essential role in many biological processes, but also catalyzes the formation of reactive oxygen species (ROS), which can cause molecular damage. Iron homeostasis is therefore a critical determinant of fitness. In Caenorhabditis elegans, insulin/IGF-1 signaling (IIS) promotes growth and reproduction but limits stress resistance and lifespan through inactivation of the DAF-16/FoxO transcription factor (TF). We report that long-lived daf-2 insulin/IGF-1 receptor mutants show a daf-16–dependent increase in expression of ftn-1, which encodes the iron storage protein H-ferritin. To better understand the regulation of iron homeostasis, we performed a TF–limited genetic screen for factors influencing ftn-1 gene expression. The screen identified the heat-shock TF hsf-1, the MAD bHLH TF mdl-1, and the putative histone acetyl transferase ada-2 as activators of ftn-1 expression. It also revealed that the HIFα homolog hif-1 and its binding partner aha-1 (HIFβ) are potent repressors of ftn-1 expression. ftn-1 expression is induced by exposure to iron, and we found that hif-1 was required for this induction. In addition, we found that the prolyl hydroxylase EGL-9, which represses HIF-1 via the von Hippel-Lindau tumor suppressor VHL-1, can also act antagonistically to VHL-1 in regulating ftn-1. This suggests a novel mechanism for HIF target gene regulation by these evolutionarily conserved and clinically important hydroxylases. Our findings imply that the IIS and HIF pathways act together to regulate iron homeostasis in C. elegans. We suggest that IIS/DAF-16 regulation of ftn-1 modulates a trade-off between growth and stress resistance, as elevated iron availability supports growth but also increases ROS production

    The Effect of Natural Dissolved Organic Carbon on the Acute Toxicity of Copper to Larval Freshwater Mussels (\u3cem\u3eGlochidia\u3c/em\u3e)

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    The present study examined the effect of dissolved organic carbon (DOC), both added and inherent, on Cu toxicity in glochidia, the larvae of freshwater mussels. Using incremental additions of natural DOC concentrate and reconstituted water, a series of acute copper toxicity tests were conducted. An increase in DOC from 0.7 to 4.4 mg C/L resulted in a fourfold increase (36–150 μg Cu/L) in the 24-h median effective concentration (EC50) and a significant linear relationship (r2=0.98, p=0.0008) between the DOC concentration and the Cu EC50 of Lampsilis siliquoidea glochidia. The ameliorating effect of added DOC on Cu toxicity was confirmed using a second mussel species, the endangered (in Canada) Lampsilis fasciola. The effect of inherent (i.e., not added) DOC on Cu toxicity was also assessed in eight natural waters (DOC 5–15 mg C/L). These experiments revealed a significant relationship between the EC50 and the concentration of inherent DOC (r2=0.79, p=0.0031) with EC50s ranging from 27 to 111 μg Cu/L. These laboratory tests have demonstrated that DOC provides glochidia with significant protection from acute Cu toxicity. The potential risk that Cu poses to mussel populations was assessed by comparing Cu and DOC concentrations from significant mussel habitats in Ontario to the EC50s. Although overall mean Cu concentration in the mussel’s habitat was well below the acutely toxic level given the concentration of DOC, episodic Cu releases in low DOC waters may be a concern for the recovery of endangered freshwater mussels. The results are examined in the context of current Cu water quality regulations including the U.S. Environmental Protection Agency’s (U.S. EPA) biotic ligand model

    The Flip Diameter of Rectangulations and Convex Subdivisions

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    We study the configuration space of rectangulations and convex subdivisions of nn points in the plane. It is shown that a sequence of O(nlogn)O(n\log n) elementary flip and rotate operations can transform any rectangulation to any other rectangulation on the same set of nn points. This bound is the best possible for some point sets, while Θ(n)\Theta(n) operations are sufficient and necessary for others. Some of our bounds generalize to convex subdivisions of nn points in the plane.Comment: 17 pages, 12 figures, an extended abstract has been presented at LATIN 201

    Recent Longitudinal Spin Asymmetry Measurements for Inclusive Jet Production at STAR

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    We present measurements of the longitudinal spin asymmetry, ALLA_{LL}, for the inclusive jet signal at STAR. The data presented here are mid-rapidity jets in the transverse momentum range of 5<pT<355<pT<35 GeV/c and come from polarized proton-proton collisions at center of mass energies of s=200\sqrt{s}=200 GeV. We compare our measured ALLA_{LL} values to predictions derived from various parameterizations of the polarized gluon distribution function. The results are shown to provide significant constraints for allowable gluon parameterizations within the measurement's kinematic Bjorken-x range of 0.03<x<0.30.03<x<0.3.Comment: 3 pages, 4 figures, to appear in PANIC 2008 Proceedings, Nuclear Physics A special issu

    Cirrus microphysics and radiative transfer: Cloud field study on October 28, 1986

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    The radiative properties of cirrus clouds present one of the unresolved problems in weather and climate research. Uncertainties in ice particle amount and size and, also, the general inability to model the single scattering properties of their usually complex particle shapes, prevent accurate model predictions. For an improved understanding of cirrus radiative effects, field experiments, as those of the Cirrus IFO of FIRE, are necessary. Simultaneous measurements of radiative fluxes and cirrus microphysics at multiple cirrus cloud altitudes allows the pitting of calculated versus measured vertical flux profiles; with the potential to judge current cirrus cloud modeling. Most of the problems in this study are linked to the inhomogeneity of the cloud field. Thus, only studies on more homogeneous cirrus cloud cases promises a possibility to improve current cirrus parameterizations. Still, the current inability to detect small ice particles will remain as a considerable handicap
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